Treatment of Autoimmune Bullous Disorders in Pregnancy.

Abstract:

:Autoimmune bullous diseases (AIBD), including pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, and pemphigoid gestationis, pose significant therapeutic challenges, especially in pregnant and post-partum breastfeeding patients or those planning to conceive. Data on the safety and efficacy of therapeutic interventions during the perinatal period are lacking because randomized controlled trials are typically not performed in this setting. However, many of the treatments for AIBD are also used in other diseases, so data can be extrapolated from studies or case reports in these other patient populations. It appears that many of the treatments for AIBD can adversely affect the fetus or neonate, and alterations in immune status caused by pregnancy-associated hormonal changes can negatively impact disease control. This article summarizes and weighs the risks and benefits of the various agents used to treat AIBD during pregnancy. We also present the available information on lactation as well as effects on male fertility.

journal_name

Am J Clin Dermatol

authors

Kushner CJ,Concha JSS,Werth VP

doi

10.1007/s40257-018-0342-0

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

391-403

issue

3

eissn

1175-0561

issn

1179-1888

pii

10.1007/s40257-018-0342-0

journal_volume

19

pub_type

杂志文章,评审
  • Optimal management of acne to prevent scarring and psychological sequelae.

    abstract::Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200102030-00002

    authors: Layton AM

    更新日期:2001-01-01 00:00:00

  • The Future of Molecular Analysis in Melanoma: Diagnostics to Direct Molecularly Targeted Therapy.

    abstract::Melanoma is a malignancy of pigment-producing cells that is driven by a variety of genetic mutations and aberrations. In most cases, this leads to upregulation of the mitogen-activated protein kinase (MAPK) pathway through activating mutations of upstream mediators of the pathway including BRAF and NRAS. With the adve...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0159-z

    authors: Akabane H,Sullivan RJ

    更新日期:2016-02-01 00:00:00

  • Adverse cutaneous reactions to mood stabilizers.

    abstract::Of all the psychotropic medications currently available, the mood-stabilizing agents have the highest incidence of severe and life-threatening adverse cutaneous drug reactions (ACDRs). An exanthematous eruption in a patient treated with a mood-stabilizing agent should be viewed as possibly being the initial symptom of...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200304010-00003

    authors: Warnock JK,Morris DW

    更新日期:2003-01-01 00:00:00

  • Risk of Suicidality in People with Psoriasis: A Systematic Review and Meta-Analysis of Cohort Studies.

    abstract:BACKGROUND:Psoriasis has been associated with psychiatric disorders such as depression and anxiety, but its relationship with suicidality (including suicide, suicide attempt, and suicidal ideation) is unclear. OBJECTIVE:Our objective was to assess the risk of suicide, suicide attempt, suicidal ideation, and suicidalit...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s40257-017-0281-1

    authors: Chi CC,Chen TH,Wang SH,Tung TH

    更新日期:2017-10-01 00:00:00

  • Quality of life in family members of vitiligo patients: a questionnaire study in Saudi Arabia.

    abstract:BACKGROUND:Many dermatologic disorders are known to adversely affect quality of life (QoL) in close relatives or partners of patients; however, it is unknown whether vitiligo impacts the QoL of family members. OBJECTIVE:The aim of this study was to identify the level and domains in which the QoL of partners/relatives ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.1007/s40257-013-0037-5

    authors: Bin Saif GA,Al-Balbeesi AO,Binshabaib R,Alsaad D,Kwatra SG,Alzolibani AA,Yosipovitch G

    更新日期:2013-12-01 00:00:00

  • Treating Alopecia Areata: Current Practices Versus New Directions.

    abstract::Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Many treatments are available; however, the efficacy of these treatments has ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-016-0230-4

    authors: Gupta AK,Carviel J,Abramovits W

    更新日期:2017-02-01 00:00:00

  • Postinflammatory hyperpigmentation: etiologic and therapeutic considerations.

    abstract::Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients. Studies show that dyschromias, including PIH, are one of the most common presenting co...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11536930-000000000-00000

    authors: Callender VD,St Surin-Lord S,Davis EC,Maclin M

    更新日期:2011-04-01 00:00:00

  • Cutaneous manifestations of syphilis : recognition and management.

    abstract::After a marked decline in the number of syphilis cases in the context of AIDS prevention campaigns, a significant increase has been observed in states of the former Soviet Union since 1994. In recent years, outbreaks have also been reported in the US, Canada, and several European countries. The current epidemic in the...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200607050-00003

    authors: Lautenschlager S

    更新日期:2006-01-01 00:00:00

  • Assessing quality of life in patients with acne vulgaris: implications for treatment.

    abstract::Diagnosing acne is easy. However, treatment must be adapted to the type and severity of acne, and must also take into account the impact of acne on patients' quality of life. As there is not always a correlation between the severity of acne and its impact on quality of life, it can be helpful for the dermatologist to ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200607020-00003

    authors: Dréno B

    更新日期:2006-01-01 00:00:00

  • Granular Parakeratosis: A Comprehensive Review and a Critical Reappraisal.

    abstract::Granular parakeratosis (GP) is a rare, idiopathic, and benign skin condition that presents classically as erythematous to brown hyperkeratotic papules that can coalesce into plaques. Axillary GP was initially observed by Northcutt and colleagues and has since been described in various other areas of the body including...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0148-2

    authors: Ding CY,Liu H,Khachemoune A

    更新日期:2015-12-01 00:00:00

  • The Asian dermatologic patient: review of common pigmentary disorders and cutaneous diseases.

    abstract::The Asian patient with Fitzpatrick skin types III-V is rarely highlighted in publications on cutaneous disorders or cutaneous laser surgery. However, with changing demographics, Asians will become an increasingly important group in this context. Although high melanin content confers better photoprotection, photodamage...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200910030-00002

    authors: Ho SG,Chan HH

    更新日期:2009-01-01 00:00:00

  • Paraneoplastic erythema annulare centrifugum eruption: PEACE.

    abstract::Erythema annulare centrifugum is a reactive erythema of various possible etiologies including, although less often, an associated cancer. Cancer-related erythema annulare centrifugum is most commonly associated with lymphoproliferative malignancies, specifically lymphoma and leukemia. Malignancy-associated erythema an...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11596580-000000000-00000

    authors: Chodkiewicz HM,Cohen PR

    更新日期:2012-08-01 00:00:00

  • Photoaging: prevention and topical treatments.

    abstract::A rapidly increasing number of people visit dermatologists for the prevention and treatment of aging skin. Sun avoidance and sunscreen use are widely accepted strategies of primary prevention against photoaging. Convincing evidence shows that topical application of retinoids has an effect on reversing, at least partia...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11530210-000000000-00000

    authors: Antoniou C,Kosmadaki MG,Stratigos AJ,Katsambas AD

    更新日期:2010-01-01 00:00:00

  • Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review.

    abstract:BACKGROUND:Atopic dermatitis (AD) is an allergic disorder caused by both immunological dysregulation and epidermal barrier defect. Several studies have investigated the association between AD and mental health disorders. Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental conditions characte...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-015-0145-5

    authors: Billeci L,Tonacci A,Tartarisco G,Ruta L,Pioggia G,Gangemi S

    更新日期:2015-10-01 00:00:00

  • Black Hairy Tongue: Predisposing Factors, Diagnosis, and Treatment.

    abstract::Black hairy tongue (BHT) is a benign condition commonly found among people who smoke, have poor oral hygiene, are immunocompromised, or have a medical condition limiting their ability to practice good oral hygiene. Though this condition is harmless, patients need to be educated on etiology as many common medications a...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-017-0268-y

    authors: Schlager E,St Claire C,Ashack K,Khachemoune A

    更新日期:2017-08-01 00:00:00

  • Spotlight on retapamulin in impetigo and other uncomplicated superficial skin infections.

    abstract::Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/0128071-200809060-00010

    authors: Yang LP,Keam SJ

    更新日期:2008-01-01 00:00:00

  • Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases.

    abstract::Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate lipid, glucose, and amino acid metabolism. More recently, PPARs and corresponding ligands have been shown in skin and other organs to regulate important cellular functions, including cell proliferation and...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200809010-00002

    authors: Sertznig P,Seifert M,Tilgen W,Reichrath J

    更新日期:2008-01-01 00:00:00

  • Topical halobetasol propionate in the treatment of plaque psoriasis: a review.

    abstract::Halobetasol propionate (HP) 0.5% ointment and cream are class I topical corticosteroids. We review the efficacy and tolerability of HP for treatment of plaque psoriasis in the English language literature. The efficacy of HP ointment and cream is consistently superior to other super-potent topical corticosteroids. Loca...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200506050-00004

    authors: Rivera AM,Hsu S

    更新日期:2005-01-01 00:00:00

  • Probiotics, Prebiotics, and Synbiotics for the Treatment and Prevention of Adult Dermatological Diseases.

    abstract:BACKGROUND:Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed. OBJECTIVE:The aim of this s...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-017-0300-2

    authors: Notay M,Foolad N,Vaughn AR,Sivamani RK

    更新日期:2017-12-01 00:00:00

  • Managing Scalp Psoriasis: An Evidence-Based Review.

    abstract:BACKGROUND:Scalp psoriasis is commonly the initial presentation of psoriasis, and almost 80 % of patients with psoriasis will eventually experience it. OBJECTIVE:Although several systematic reviews and guidelines exist, an up-to-date evidence-based review including more recent progress on the use of biologics and new ...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-016-0222-4

    authors: Wang TS,Tsai TF

    更新日期:2017-02-01 00:00:00

  • Biomarkers Predictive of Survival and Response to Immune Checkpoint Inhibitors in Melanoma.

    abstract::Immunotherapy has revolutionized the treatment of melanoma. Targeting of the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 has led to improved survival in a subset of patients. Unfortunately, the use of immune checkpoint inhibitors is associated with significant sid...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-019-00475-1

    authors: Rizk EM,Seffens AM,Trager MH,Moore MR,Geskin LJ,Gartrell-Corrado RD,Wong W,Saenger YM

    更新日期:2020-02-01 00:00:00

  • Treatment of systemic sclerosis.

    abstract::Systemic sclerosis is an extremely variable disease in its manifestations and consequently, treatment needs to be individualized depending on the specific problems that each patient has. Limited scleroderma patients have a prolonged duration of Raynaud's phenomenon and puffy fingers before they develop any skin thicke...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200102050-00006

    authors: Steen VD

    更新日期:2001-01-01 00:00:00

  • Use of etanercept in the dermatology setting. A review.

    abstract::As psoriasis and psoriatic arthritis are chronic in nature, ideal treatment should have sustained efficacy, with minimal short- and long-term toxicities to allow lifelong treatment. Traditional therapies used for psoriatic arthritis or psoriasis, including phototherapies and systemic agents, do not satisfy these crite...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200506010-00006

    authors: Lebwohl MG

    更新日期:2005-01-01 00:00:00

  • Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions.

    abstract::Non-infectious granulomatous diseases of the skin are a broad group of distinct reactive inflammatory conditions that share important similarities. As a group, they are relatively difficult to diagnose and distinguish both clinically as well as histologically. Many of these disorders have significant associations with...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/11530080-000000000-00000

    authors: Hawryluk EB,Izikson L,English JC 3rd

    更新日期:2010-01-01 00:00:00

  • Diagnosis and management of uncommon cutaneous cancers.

    abstract::Uncommon types of cutaneous cancers are mainly cited in the literature as case reports and their etiology, pathogenesis and prognosis have to be surmised because of their rarity. Within this group exist the rare and also the unusual, for instance a relatively common carcinoma arising in a strange circumstance. Initial...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.2165/00128071-200203020-00002

    authors: Topping A,Wilson GR

    更新日期:2002-01-01 00:00:00

  • Trigeminal trophic syndrome from stroke: an under-recognized central neuropathic itch syndrome.

    abstract::Trigeminal trophic syndrome (TTS) is the historic name for neuropathic self-induced facial ulceration from abnormal sensory symptoms leading to uncontrolled scratching. Anatomic co-localization of sensory loss (numbness) plus neuropathic itch and pain permits painless scratching. If the itch is severe, some patients w...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/11594060-000000000-00000

    authors: Curtis AR,Oaklander AL,Johnson A,Yosipovitch G

    更新日期:2012-04-01 00:00:00

  • Risk of sudden sensorineural hearing loss in patients with psoriasis: a retrospective cohort study.

    abstract:SIGNIFICANCE:Psoriasis, a common immune-mediated disease, affects approximately 2% of the population worldwide. Sudden sensorineural hearing loss (SSNHL) might be a manifestation of systemic vascular involvement in autoimmune disease. However, to the best of our knowledge, there is no systematic English-language examin...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.1007/s40257-015-0117-9

    authors: Yen YC,Lin YS,Weng SF,Lai FJ

    更新日期:2015-06-01 00:00:00

  • Comparative study of 2% sertaconazole solution and cream formulations in patients with tinea corporis, tinea pedis interdigitalis, or a corresponding candidosis.

    abstract:BACKGROUND:Based on the results of numerous preclinical and clinical studies, sertaconazole can be considered a safe and effective drug for the treatment of fungal skin infections. OBJECTIVE:The objective of the study was to compare the efficacy of a solution containing 2% sertaconazole with the well established 2% se...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2165/00128071-200708060-00007

    authors: Borelli C,Klövekorn G,Ernst TM,Bödeker RH,Korting HC,Neumeister C

    更新日期:2007-01-01 00:00:00

  • Erythroid disturbances before and after treatment of Portuguese psoriasis vulgaris patients: a cross-sectional and longitudinal study.

    abstract:BACKGROUND:A few studies in psoriasis vulgaris patients have reported changes suggesting red blood cell (RBC) damage is linked to neutrophil activation, oxidative stress, and psoriasis worsening. OBJECTIVE:The aim of this study was to evaluate erythroid disturbances in Portuguese psoriasis vulgaris patients, before, d...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章

    doi:10.2165/11592110-000000000-00000

    authors: Coimbra S,Oliveira H,Reis F,Belo L,Rocha S,Quintanilha A,Figueiredo A,Teixeira F,Castro E,Rocha-Pereira P,Santos-Silva A

    更新日期:2012-02-01 00:00:00

  • Homeostasis in Topical Photoprotection: Getting the Spectral Balance Right.

    abstract::The solar radiation range has harmful and beneficial effects. Sunscreens, which selectively block specific spectral regions, may potentially interfere with skin homeostasis. For instance, the ultraviolet (UV) B waveband produces erythema and DNA damage; simultaneously, it induces pre-vitamin D3 synthesis. UVA1 and vis...

    journal_title:American journal of clinical dermatology

    pub_type: 杂志文章,评审

    doi:10.1007/s40257-018-0369-2

    authors: Stengel F

    更新日期:2018-11-01 00:00:00