Abstract:
:A recent experiment involving simian immunodeficiency virus (SIV) infection of macaques revealed that the infectivity of this virus decreased over the first few months of infection. Based on this observation, we introduce a viral dynamic model in which viral infectivity varies over time. The model is fit to viral load data from eight (donor) monkeys infected by intravaginal inoculation of SIVmac251, three monkeys infected by intravenous inoculation of virus isolated from the donors during the ramp-up phase of acute infection, and three monkeys infected by intravenous inoculation of virus isolated at the viral set-point. Although we only analyze data from 14 monkeys, the new model with time-dependent infectivity seems to fit the data significantly better than a widely used model with constant infectivity (P = 2.44 x 10(-11)). Our results indicate that plasma virus infectivity on average decays approximately 8-fold (95% confidence interval [CI] = 5.1 to 10.3) over the course of acute infection, with the decay occurring exponentially with an average rate of 0.28 day(-1) (95% CI = 0.14 to 0.42 day(-1)). The decay rate in set point plasma virus recipient animals is approximately 16 times slower than in ramp-up plasma virus recipient animals and approximately 6 times slower than in donor animals. Throughout acute infection up to the set-point, the infection rate is higher in ramp-up plasma virus recipient animals than in set-point plasma virus recipient animals. These results show that the infectivity depends upon the source of viral infection.
journal_name
J Viroljournal_title
Journal of virologyauthors
Vaidya NK,Ribeiro RM,Miller CJ,Perelson ASdoi
10.1128/JVI.02284-09subject
Has Abstractpub_date
2010-05-01 00:00:00pages
4302-10issue
9eissn
0022-538Xissn
1098-5514pii
JVI.02284-09journal_volume
84pub_type
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