Abstract:
:While cholera has been a recognized disease for two centuries, there is no strategy for its effective control. We formulate a mathematical model to include essential components such as a hyperinfectious, short-lived bacterial state, a separate class for mild human infections, and waning disease immunity. A new result quantifies contributions to the basic reproductive number from multiple infectious classes. Using optimal control theory, parameter sensitivity analysis, and numerical simulations, a cost-effective balance of multiple intervention methods is compared for two endemic populations. Results provide a framework for designing cost-effective strategies for diseases with multiple intervention methods.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Miller Neilan RL,Schaefer E,Gaff H,Fister KR,Lenhart Sdoi
10.1007/s11538-010-9521-8subject
Has Abstractpub_date
2010-11-01 00:00:00pages
2004-18issue
8eissn
0092-8240issn
1522-9602journal_volume
72pub_type
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