Abstract:
:The F-actin network and cytosol in the lamellipodia of crawling cells flow in a centripetal pattern and spout-like form, respectively. We have numerically studied this two-phase flow in the realistic geometry of a moving keratocyte. Cytosol has been treated as a low viscosity Newtonian fluid flowing through the high viscosity porous medium of F-actin network. Other involved phenomena including myosin activity, adhesion friction, and interphase interaction are also discussed to provide an overall view of this problem. Adopting a two-phase coupled model by myosin concentration, we have found new accurate perspectives of acto-cytosolic flow and pressure fields, myosin distribution, as well as the distribution of effective forces across the lamellipodia of a keratocyte with stationary shape. The order of magnitude method is also used to determine the contribution of forces in the internal dynamics of lamellipodia.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Nikmaneshi MR,Firoozabadi B,Saidi MSdoi
10.1007/s11538-015-0105-5subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1813-32issue
9eissn
0092-8240issn
1522-9602pii
10.1007/s11538-015-0105-5journal_volume
77pub_type
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