Hybridization and speciation in angiosperms: a role for pollinator shifts?

abstract：BACKGROUND:Internal tagging of proteins by inserting small functional peptides into surface accessible permissive sites has proven to be an indispensable tool for basic and applied science. Permissive sites are typically identified by transposon mutagenesis on a case-by-case basis, limiting scalability and their exploi...

journal_title：BMC biology

authors： Oesterle S,Roberts TM,Widmer LA,Mustafa H,Panke S,Billerbeck S

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the polyploid nature, high genome complexity and lack of genomic sequence integration with reproductive tiss...

journal_title：BMC biology

authors： Rabiger DS,Taylor JM,Spriggs A,Hand ML,Henderson ST,Johnson SD,Oelkers K,Hrmova M,Saito K,Suzuki G,Mukai Y,Carroll BJ,Koltunow AM

更新日期：2016-10-06 00:00:00

abstract：:The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or ch...

journal_title：BMC biology

authors： Nakayama T,Archibald JM

更新日期：2012-04-24 00:00:00

abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...

journal_title：BMC biology

authors： Gordon-Keylock S,Medvinsky A

更新日期：2011-12-28 00:00:00

abstract：BACKGROUND:Insects helped pioneer, and persist as model organisms for, the study of specific aspects of immunity. Although they lack an adaptive immune system, insects possess an innate immune system that recognizes and destroys intruding microorganisms. Its operation under natural conditions has not been well studied,...

journal_title：BMC biology

authors： Freitak D,Wheat CW,Heckel DG,Vogel H

更新日期：2007-12-21 00:00:00

abstract：BACKGROUND:The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant ...

journal_title：BMC biology

authors： Boursereau R,Abou-Samra M,Lecompte S,Noel L,Brichard SM

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:A genome-wide association study (GWAS) is the foremost strategy used for finding genes that control human diseases and agriculturally important traits, but it often reports false positives. In contrast, its complementary method, linkage analysis, provides direct genetic confirmation, but with limited resolut...

journal_title：BMC biology

authors： Li C,Li Y,Bradbury PJ,Wu X,Shi Y,Song Y,Zhang D,Rodgers-Melnick E,Buckler ES,Zhang Z,Li Y,Wang T

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:A key event in plant morphogenesis is the establishment of a division plane. A plant-specific microtubular preprophase band (PPB) accurately predicts the line of cell division, whereas the phragmoplast, another plant-specific array, executes cell division by maintaining this predicted line. Although establis...

journal_title：BMC biology

authors： Dhonukshe P,Mathur J,Hülskamp M,Gadella TW Jr

更新日期：2005-04-14 00:00:00

abstract：:The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in mediating these responses. See research article http://www.biomedcentra...

journal_title：BMC biology

authors： Whitmarsh AJ

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living cells. Recently, fluorescence resonance energy transfer (FRET) sensors...

journal_title：BMC biology

authors： Adjobo-Hermans MJ,Goedhart J,van Weeren L,Nijmeijer S,Manders EM,Offermanns S,Gadella TW Jr

更新日期：2011-05-27 00:00:00

abstract：BACKGROUND:Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epithelial cells are relatively well studied, molecular markers of lung mesenchymal cells and the genetic...

journal_title：BMC biology

authors： Zhang W,Menke DB,Jiang M,Chen H,Warburton D,Turcatel G,Lu CH,Xu W,Luo Y,Shi W

更新日期：2013-11-13 00:00:00

abstract：:The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mou...

journal_title：BMC biology

authors： Bell G

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on grafting-resistant North American Vitis species as rootstocks, thereby limiting genetic stocks to...

journal_title：BMC biology

authors： Rispe C,Legeai F,Nabity PD,Fernández R,Arora AK,Baa-Puyoulet P,Banfill CR,Bao L,Barberà M,Bouallègue M,Bretaudeau A,Brisson JA,Calevro F,Capy P,Catrice O,Chertemps T,Couture C,Delière L,Douglas AE,Dufault-Thompson K

更新日期：2020-07-23 00:00:00

abstract：BACKGROUND:Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all...

journal_title：BMC biology

authors： Volkers RJ,Snoek LB,Hubar CJ,Coopman R,Chen W,Yang W,Sterken MG,Schulenburg H,Braeckman BP,Kammenga JE

更新日期：2013-08-19 00:00:00

abstract：:In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...

journal_title：BMC biology

authors： Bell G

更新日期：2016-06-23 00:00:00

abstract：BACKGROUND:The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experience-dependent transgenerational inheritance. However, questions remain unanswered as to how heritabl...

journal_title：BMC biology

authors： O'Brien EA,Ensbey KS,Day BW,Baldock PA,Barry G

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Male sexually selected vocalisations generally contain both individuality and quality cues that are crucial in intra- as well as inter-sexual communication. As individuality is a fixed feature whereas male phenotypic quality changes with age, individuality and quality cues may be subjected to different selec...

journal_title：BMC biology

authors： Briefer E,Vannoni E,McElligott AG

更新日期：2010-04-09 00:00:00

abstract：:Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcriptio...

journal_title：BMC biology

authors： Koonin EV,Krupovic M,Ishino S,Ishino Y

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...

journal_title：BMC biology

authors： Sunagar K,Columbus-Shenkar YY,Fridrich A,Gutkovich N,Aharoni R,Moran Y

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:Sec8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function, including neurite outgrowth, calcium-dependent neurotransmitter secretion, trafficking of ionotropic glutamate receptors and regulation of neuronal microtubule ass...

journal_title：BMC biology

authors： Liebl FL,Chen K,Karr J,Sheng Q,Featherstone DE

更新日期：2005-12-13 00:00:00

abstract：BACKGROUND:Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate proteins. A diffe...

journal_title：BMC biology

authors： Peleh V,Zannini F,Backes S,Rouhier N,Herrmann JM

更新日期：2017-11-08 00:00:00

abstract：BACKGROUND:Methods for assigning strains to bacterial species are cumbersome and no longer fit for purpose. The concatenated sequences of multiple house-keeping genes have been shown to be able to define and circumscribe bacterial species as sequence clusters. The advantage of this approach (multilocus sequence analysi...

journal_title：BMC biology

authors： Bishop CJ,Aanensen DM,Jordan GE,Kilian M,Hanage WP,Spratt BG

更新日期：2009-01-26 00:00:00

abstract：BACKGROUND:How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. RESULTS:By exploring the possible effects of v...

journal_title：BMC biology

authors： Buzi G,Lander AD,Khammash M

更新日期：2015-02-19 00:00:00

abstract：BACKGROUND:ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen identified protein kinase C delta (PKCδ) as a potential ARTD10 substrate, amo...

journal_title：BMC biology

authors： Tian Y,Korn P,Tripathi P,Komnig D,Wiemuth D,Nikouee A,Classen A,Bolm C,Falkenburger BH,Lüscher B,Gründer S

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracti...

journal_title：BMC biology

authors： van Kessel SP,de Jong HR,Winkel SL,van Leeuwen SS,Nelemans SA,Permentier H,Keshavarzian A,El Aidy S

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：:The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, th...

journal_title：BMC biology

authors： Perelson AS,Ribeiro RM

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of standardized a...

journal_title：BMC biology

authors： Hundeshagen P,Hamacher-Brady A,Eils R,Brady NR

更新日期：2011-06-02 00:00:00

abstract：BACKGROUND:The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potential confounder of these sequence-based approaches is the presence of contamination in DNA extraction ...

journal_title：BMC biology

authors： Salter SJ,Cox MJ,Turek EM,Calus ST,Cookson WO,Moffatt MF,Turner P,Parkhill J,Loman NJ,Walker AW

更新日期：2014-11-12 00:00:00

abstract：:Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic...

journal_title：BMC biology

authors： Rappuoli R

更新日期：2014-11-29 00:00:00