解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The global spread of SARS-CoV-2 has shaken our health care and economic systems, prompting re-evaluation of long-held views on how best to deliver care. This is especially the case for our global diagnostic strategy. While current laboratory-based centralized RT-qPCR will continue to serve as a gold standard diagnosti...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00891-4
更新日期:2020-10-28 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracti...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00876-3
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:The western flower thrips, Frankliniella occidentalis (Pergande), is a globally invasive pest and plant virus vector on a wide array of food, fiber, and ornamental crops. The underlying genetic mechanisms of the processes governing thrips pest and vector biology, feeding behaviors, ecology, and insecticide r...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00862-9
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen identified protein kinase C delta (PKCδ) as a potential ARTD10 substrate, amo...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00878-1
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Vertebrates are characterized by possession of hypobranchial muscles (HBMs). Cyclostomes, or modern jawless vertebrates, possess a rudimentary and superficial HBM lateral to the pharynx, whereas the HBM in jawed vertebrates is internalized and anteroposteriorly specified. Precursor cells of the HBM, marked b...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00851-y
更新日期:2020-09-09 00:00:00
abstract:BACKGROUND:Gene drives based on CRISPR-Cas9 technology are increasingly being considered as tools for reducing the capacity of mosquito populations to transmit malaria, and one of the most promising options is driving endonuclease genes that reduce the fertility of female mosquitoes. In particular, there is much intere...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00834-z
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on grafting-resistant North American Vitis species as rootstocks, thereby limiting genetic stocks to...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00820-5
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS:As a proof of principle, we show in both cell lines and primary cell cultu...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00790-8
更新日期:2020-07-03 00:00:00
abstract:BACKGROUND:Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (AC...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00791-7
更新日期:2020-06-16 00:00:00
abstract::Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcriptio...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00800-9
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis of aquatic primary production; most taxa are free-living, while some can form symbiotic and parasiti...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00782-8
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been proposed on their basis. However, the difficulty in investigating complex I semiquinones, due to the...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00768-6
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:One hundred years ago, marine organisms were the dominant systems for the study of developmental biology. The challenges in rearing these organisms outside of a marine setting ultimately contributed to a shift towards work on a smaller number of so-called model systems. Those animals are typically non-marine...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00772-w
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experience-dependent transgenerational inheritance. However, questions remain unanswered as to how heritabl...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00780-w
更新日期:2020-04-30 00:00:00
abstract:BACKGROUND:The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple categories of ncRNAs and characterization of the way their expression is regulated. We previously sho...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-0763-0
更新日期:2020-04-13 00:00:00
abstract:BACKGROUND:The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal muscles of patients ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00767-7
更新日期:2020-03-26 00:00:00
abstract:BACKGROUND:Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identities have been assigned to all neurons, the number of annotatable neurons in an intact animal has...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-0745-2
更新日期:2020-03-19 00:00:00
abstract:BACKGROUND:CRISPR gene drive systems allow the rapid spread of a genetic construct throughout a population. Such systems promise novel strategies for the management of vector-borne diseases and invasive species by suppressing a target population or modifying it with a desired trait. However, current homing-type drives ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-0761-2
更新日期:2020-03-12 00:00:00
abstract::Animal domestication has fascinated biologists since Charles Darwin first drew the parallel between evolution via natural selection and human-mediated breeding of livestock and companion animals. In this review we show how studies of ancient DNA from domestic animals and their wild progenitors and congeners have shed ...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/s12915-019-0724-7
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Cellular functions can be regulated by cell-cell interactions that are influenced by extra-cellular, density-dependent signaling factors. Dictyostelium grow as individual cells in nutrient-rich sources, but, as nutrients become depleted, they initiate a multi-cell developmental program that is dependent upon...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0714-9
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0715-8
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)- or homology-directed repair-m...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0711-z
更新日期:2019-11-18 00:00:00
abstract:BACKGROUND:ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III filam...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0700-2
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:Effective disease management depends on timely and accurate diagnosis to guide control measures. The capacity to distinguish between individuals in a pathogen population with specific properties such as fungicide resistance, toxin production and virulence profiles is often essential to inform disease managem...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0684-y
更新日期:2019-08-13 00:00:00
abstract:BACKGROUND:Kinases mTORC1 and AMPK act as energy sensors, controlling nutrient responses and cellular growth. Changes in nutrient levels affect diverse transcriptional networks, making it challenging to identify downstream paths that regulate cellular growth or a switch to development via nutrient variation. The life c...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0673-1
更新日期:2019-07-18 00:00:00
abstract:BACKGROUND:The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation initiation factors are also commonly found to be either amplified or mis-regulated in tumours, includ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0658-0
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0651-7
更新日期:2019-04-17 00:00:00
abstract:BACKGROUND:Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as reservoirs of resistance genes for human pathogens. Anthropogenic activity may contribute to the sp...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0649-1
更新日期:2019-04-08 00:00:00
abstract:BACKGROUND:The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a drivi...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0645-5
更新日期:2019-03-29 00:00:00
abstract::Few would argue that science is better done in silos, with no transparency or sharing of methods and resources. Yet scientists and scientific stakeholders (e.g., academic institutions, funding agencies, journals) alike continue to find themselves at a relative impasse in the implementation of open science practices, s...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0647-3
更新日期:2019-03-27 00:00:00
abstract:BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0633-9
更新日期:2019-02-22 00:00:00
abstract:BACKGROUND:Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the number of non-coding RNAs identified in various organisms. While we have mechanistic underst...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0635-7
更新日期:2019-02-18 00:00:00
abstract:BACKGROUND:The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. reinhardtii, yet only two-the channelrhodopsins-were functionally characterized. Characterization of ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0613-5
更新日期:2018-12-06 00:00:00
abstract:BACKGROUND:Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0609-1
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embedded in the gene regulatory networks that orchestrate embryogenesis. Knotted-like homeobox (KNOX) TF...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0605-5
更新日期:2018-11-05 00:00:00
abstract::Joel Dacks is an Associate Professor and Canada Research Chair in Evolutionary Cell Biology at the University of Alberta, a Scientific Associate at the Natural History Museum (London), and the current President of the International Society for Evolutionary Protistology. His research group studies the evolution and div...
journal_title:BMC biology
pub_type: 传,历史文章,面试
doi:10.1186/s12915-018-0586-4
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0578-4
更新日期:2018-09-27 00:00:00
abstract::CRISPR-Cas systems, the purveyors of adaptive immunity in archaea and bacteria and sources of the new generation of genome engineering tools, have been studied in exquisite molecular detail. However, when it comes to biological functions, ecology, and evolution of CRISPR-Cas, many more intriguing questions remain than...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0565-9
更新日期:2018-09-24 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission. Here, we evaluate the impact of fo...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0567-7
更新日期:2018-09-10 00:00:00
abstract::Huntington's disease (HD) is one of the most common tandem repeat disorders and presents as a unique trilogy of cognitive, psychiatric and motor symptoms. One of the major mysteries of HD is why it selectively affects specific neuronal populations. A new article in BMC Biology provides a piece in the puzzle of pathoge...
journal_title:BMC biology
pub_type: 评论,杂志文章
doi:10.1186/s12915-018-0539-y
更新日期:2018-06-27 00:00:00