Abstract:
:Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD.
journal_name
BMC Bioljournal_title
BMC biologyauthors
Koonin EV,Krupovic M,Ishino S,Ishino Ydoi
10.1186/s12915-020-00800-9subject
Has Abstractpub_date
2020-06-09 00:00:00pages
61issue
1issn
1741-7007pii
10.1186/s12915-020-00800-9journal_volume
18pub_type
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