The replication machinery of LUCA: common origin of DNA replication and transcription.

Abstract:

:Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD.

journal_name

BMC Biol

journal_title

BMC biology

authors

Koonin EV,Krupovic M,Ishino S,Ishino Y

doi

10.1186/s12915-020-00800-9

subject

Has Abstract

pub_date

2020-06-09 00:00:00

pages

61

issue

1

issn

1741-7007

pii

10.1186/s12915-020-00800-9

journal_volume

18

pub_type

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