当前位置： SCI文献检索 > BMC BIOLOGY期刊下所有文献 > The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K+ channel Kv1.1 through protein kinase C delta.

The mono-ADP-ribosyltransferase ARTD10 regulates the voltage-gated K+ channel Kv1.1 through protein kinase C delta.

Abstract：

BACKGROUND:ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen identified protein kinase C delta (PKCδ) as a potential ARTD10 substrate, among several other kinases. The voltage-gated K+ channel Kv1.1 constitutes one of the dominant Kv channels in neurons of the central nervous system and the inactivation properties of Kv1.1 are modulated by PKC. In this study, we addressed the role of ARTD10-PKCδ as a regulator of Kv1.1. RESULTS:We found that ARTD10 inhibited PKCδ, which increased Kv1.1 current amplitude and the proportion of the inactivating current component in HeLa cells, indicating that ARTD10 regulates Kv1.1 in living cells. An inhibitor of ARTD10, OUL35, significantly decreased peak amplitude together with the proportion of the inactivating current component of Kv1.1-containing channels in primary hippocampal neurons, demonstrating that the ARTD10-PKCδ signaling cascade regulates native Kv1.1. Moreover, we show that the pharmacological blockade of ARTD10 increases excitability of hippocampal neurons. CONCLUSIONS:Our results, for the first time, suggest that MARylation by ARTD10 controls neuronal excitability.

journal_name

BMC Biol

journal_title

BMC biology

authors

Tian Y,Korn P,Tripathi P,Komnig D,Wiemuth D,Nikouee A,Classen A,Bolm C,Falkenburger BH,Lüscher B,Gründer S

doi

10.1186/s12915-020-00878-1

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

143

issue

1

issn

1741-7007

pii

10.1186/s12915-020-00878-1

journal_volume

18

pub_type

杂志文章

相关文献

BMC BIOLOGY文献大全
  • Endothelio-hematopoietic relationship: getting closer to the beginnings.

    abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...

    journal_title：BMC biology

    pub_type： 社论

    doi：10.1186/1741-7007-9-88

    authors： Gordon-Keylock S,Medvinsky A

    更新日期：2011-12-28 00:00:00

  • The intestinal microbiota regulates host cholesterol homeostasis.

    abstract：BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-019-0715-8

    authors： Le Roy T,Lécuyer E,Chassaing B,Rhimi M,Lhomme M,Boudebbouze S,Ichou F,Haro Barceló J,Huby T,Guerin M,Giral P,Maguin E,Kapel N,Gérard P,Clément K,Lesnik P

    更新日期：2019-11-27 00:00:00

  • Lateral gene transfer between prokaryotes and multicellular eukaryotes: ongoing and significant?

    abstract：:The expansion of genome sequencing projects has produced accumulating evidence for lateral transfer of genes between prokaryotic and eukaryotic genomes. However, it remains controversial whether these genes are of functional importance in their recipient host. Nikoh and Nakabachi, in a recent paper in BMC Biology, tak...

    journal_title：BMC biology

    pub_type： 评论,杂志文章

    doi：10.1186/1741-7007-7-20

    authors： Ros VI,Hurst GD

    更新日期：2009-05-05 00:00:00

  • Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis.

    abstract：BACKGROUND:Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes. Inactivating single oncogenes, such as c-Myc, can reverse even advanced tumours. Intrigui...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-2-26

    authors： Pelengaris S,Abouna S,Cheung L,Ifandi V,Zervou S,Khan M

    更新日期：2004-12-21 00:00:00

  • Using a chimeric respiratory chain and EPR spectroscopy to determine the origin of semiquinone species previously assigned to mitochondrial complex I.

    abstract：BACKGROUND:For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been proposed on their basis. However, the difficulty in investigating complex I semiquinones, due to the...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-020-00768-6

    authors： Wright JJ,Fedor JG,Hirst J,Roessler MM

    更新日期：2020-05-20 00:00:00

  • The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest.

    abstract：BACKGROUND:Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on grafting-resistant North American Vitis species as rootstocks, thereby limiting genetic stocks to...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-020-00820-5

    authors： Rispe C,Legeai F,Nabity PD,Fernández R,Arora AK,Baa-Puyoulet P,Banfill CR,Bao L,Barberà M,Bouallègue M,Bretaudeau A,Brisson JA,Calevro F,Capy P,Catrice O,Chertemps T,Couture C,Delière L,Douglas AE,Dufault-Thompson K

    更新日期：2020-07-23 00:00:00

  • Effects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies.

    abstract：BACKGROUND:Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Ye...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-015-0176-7

    authors： Bellesi M,de Vivo L,Tononi G,Cirelli C

    更新日期：2015-08-25 00:00:00

  • Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism.

    abstract：BACKGROUND:Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mi...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-015-0221-6

    authors： Ashmore T,Roberts LD,Morash AJ,Kotwica AO,Finnerty J,West JA,Murfitt SA,Fernandez BO,Branco C,Cowburn AS,Clarke K,Johnson RS,Feelisch M,Griffin JL,Murray AJ

    更新日期：2015-12-22 00:00:00

  • Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family.

    abstract：BACKGROUND:A new family of natural products has been described in which cysteine, serine and threonine from ribosomally-produced peptides are converted to thiazoles, oxazoles and methyloxazoles, respectively. These metabolites and their biosynthetic gene clusters are now referred to as thiazole/oxazole-modified microci...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-8-70

    authors： Haft DH,Basu MK,Mitchell DA

    更新日期：2010-05-25 00:00:00

  • p97 complexes as signal integration hubs.

    abstract：:In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent ...

    journal_title：BMC biology

    pub_type： 社论

    doi：10.1186/1741-7007-10-48

    authors： Meyer H

    更新日期：2012-06-13 00:00:00

  • Different noses for different mice and men.

    abstract：:Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...

    journal_title：BMC biology

    pub_type： 评论,杂志文章

    doi：10.1186/1741-7007-10-75

    authors： Keller A

    更新日期：2012-08-21 00:00:00

  • Frequency of influenza H3N2 intra-subtype reassortment: attributes and implications of reassortant spread.

    abstract：BACKGROUND:Increasing evidence suggests that influenza reassortment not only contributes to the emergence of new human pandemics but also plays an important role in seasonal influenza epidemics, disease severity, evolution, and vaccine efficacy. We studied this process within 2091 H3N2 full genomes utilizing a combinat...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-016-0337-3

    authors： Maljkovic Berry I,Melendrez MC,Li T,Hawksworth AW,Brice GT,Blair PJ,Halsey ES,Williams M,Fernandez S,Yoon IK,Edwards LD,Kuschner R,Lin X,Thomas SJ,Jarman RG

    更新日期：2016-12-29 00:00:00

  • Evolution of developmental roles of Pax2/5/8 paralogs after independent duplication in urochordate and vertebrate lineages.

    abstract：BACKGROUND:Gene duplication provides opportunities for lineage diversification and evolution of developmental novelties. Duplicated genes generally either disappear by accumulation of mutations (nonfunctionalization), or are preserved either by the origin of positively selected functions in one or both duplicates (neof...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-6-35

    authors： Bassham S,Cañestro C,Postlethwait JH

    更新日期：2008-08-22 00:00:00

  • African-American mitochondrial DNAs often match mtDNAs found in multiple African ethnic groups.

    abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-4-34

    authors： Ely B,Wilson JL,Jackson F,Jackson BA

    更新日期：2006-10-12 00:00:00

  • Identification of functional long non-coding RNAs in C. elegans.

    abstract：BACKGROUND:Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the number of non-coding RNAs identified in various organisms. While we have mechanistic underst...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-019-0635-7

    authors： Akay A,Jordan D,Navarro IC,Wrzesinski T,Ponting CP,Miska EA,Haerty W

    更新日期：2019-02-18 00:00:00

  • Sequence-based prediction of permissive stretches for internal protein tagging and knockdown.

    abstract：BACKGROUND:Internal tagging of proteins by inserting small functional peptides into surface accessible permissive sites has proven to be an indispensable tool for basic and applied science. Permissive sites are typically identified by transposon mutagenesis on a case-by-case basis, limiting scalability and their exploi...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-017-0440-0

    authors： Oesterle S,Roberts TM,Widmer LA,Mustafa H,Panke S,Billerbeck S

    更新日期：2017-10-30 00:00:00

  • Tales of significance.

    abstract：:In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-016-0275-0

    authors： Bell G

    更新日期：2016-06-23 00:00:00

  • Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida.

    abstract：BACKGROUND:Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embedded in the gene regulatory networks that orchestrate embryogenesis. Knotted-like homeobox (KNOX) TF...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-018-0605-5

    authors： Joo S,Wang MH,Lui G,Lee J,Barnas A,Kim E,Sudek S,Worden AZ,Lee JH

    更新日期：2018-11-05 00:00:00

  • Evolving a photosynthetic organelle.

    abstract：:The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or ch...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-10-35

    authors： Nakayama T,Archibald JM

    更新日期：2012-04-24 00:00:00

  • Origins of cellular geometry.

    abstract：:Cells are highly complex and orderly machines, with defined shapes and a startling variety of internal organizations. Complex geometry is a feature of both free-living unicellular organisms and cells inside multicellular animals. Where does the geometry of a cell come from? Many of the same questions that arise in dev...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-9-57

    authors： Marshall WF

    更新日期：2011-08-31 00:00:00

  • Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa.

    abstract：BACKGROUND:Phylostratigraphy is a method used to correlate the evolutionary origin of founder genes (that is, functional founder protein domains) of gene families with particular macroevolutionary transitions. It is based on a model of genome evolution that suggests that the origin of complex phenotypic innovations wil...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-8-66

    authors： Domazet-Loso T,Tautz D

    更新日期：2010-05-21 00:00:00

  • Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.

    abstract：BACKGROUND:The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest that this conversion occurs via a cholesterol-sensitive process, as chol...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-6-39

    authors： Bate C,Tayebi M,Diomede L,Salmona M,Williams A

    更新日期：2008-09-12 00:00:00

  • Precise A•T to G•C base editing in the zebrafish genome.

    abstract：BACKGROUND:Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-018-0609-1

    authors： Qin W,Lu X,Liu Y,Bai H,Li S,Lin S

    更新日期：2018-11-20 00:00:00

  • The golgin coiled-coil proteins capture different types of transport carriers via distinct N-terminal motifs.

    abstract：BACKGROUND:The internal organization of cells depends on mechanisms to ensure that transport carriers, such as vesicles, fuse only with the correct destination organelle. Several types of proteins have been proposed to confer specificity to this process, and we have recently shown that a set of coiled-coil proteins on ...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-016-0345-3

    authors： Wong M,Gillingham AK,Munro S

    更新日期：2017-01-26 00:00:00

  • Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?

    abstract：BACKGROUND:Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain is also elicited by natural rewards and incentive cues, raising the possibility that some CRF systems in the brain mediate an independent function of positiv...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/1741-7007-4-8

    authors： Peciña S,Schulkin J,Berridge KC

    更新日期：2006-04-13 00:00:00

  • De novo assembly of the complex genome of Nippostrongylus brasiliensis using MinION long reads.

    abstract：BACKGROUND:Eukaryotic genome assembly remains a challenge in part due to the prevalence of complex DNA repeats. This is a particularly acute problem for holocentric nematodes because of the large number of satellite DNA sequences found throughout their genomes. These have been recalcitrant to most genome sequencing met...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-017-0473-4

    authors： Eccles D,Chandler J,Camberis M,Henrissat B,Koren S,Le Gros G,Ewbank JJ

    更新日期：2018-01-11 00:00:00

  • mTORC1/AMPK responses define a core gene set for developmental cell fate switching.

    abstract：BACKGROUND:Kinases mTORC1 and AMPK act as energy sensors, controlling nutrient responses and cellular growth. Changes in nutrient levels affect diverse transcriptional networks, making it challenging to identify downstream paths that regulate cellular growth or a switch to development via nutrient variation. The life c...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-019-0673-1

    authors： Jaiswal P,Kimmel AR

    更新日期：2019-07-18 00:00:00

  • Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40.

    abstract：BACKGROUND:Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate proteins. A diffe...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-017-0445-8

    authors： Peleh V,Zannini F,Backes S,Rouhier N,Herrmann JM

    更新日期：2017-11-08 00:00:00

  • Evolving eukaryotes: an interview with Joel Dacks.

    abstract：:Joel Dacks is an Associate Professor and Canada Research Chair in Evolutionary Cell Biology at the University of Alberta, a Scientific Associate at the Natural History Museum (London), and the current President of the International Society for Evolutionary Protistology. His research group studies the evolution and div...

    journal_title：BMC biology

    pub_type： 传,历史文章,面试

    doi：10.1186/s12915-018-0586-4

    authors： Dacks JB

    更新日期：2018-11-01 00:00:00

  • Analysis of sea star larval regeneration reveals conserved processes of whole-body regeneration across the metazoa.

    abstract：BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...

    journal_title：BMC biology

    pub_type： 杂志文章

    doi：10.1186/s12915-019-0633-9

    authors： Cary GA,Wolff A,Zueva O,Pattinato J,Hinman VF

    更新日期：2019-02-22 00:00:00