Abstract：
BACKGROUND:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracting considerable attention due to their impact on gut homeostasis and host's physiology. In particular, Clostridium sporogenes is a key contributor to the production of these bioactive metabolites in the human gut. RESULTS:Here, we show that C. sporogenes deaminates levodopa, the main treatment in Parkinson's disease, and identify the aromatic aminotransferase responsible for the initiation of the deamination pathway. The deaminated metabolite from levodopa, 3-(3,4-dihydroxyphenyl)propionic acid, elicits an inhibitory effect on ileal motility in an ex vivo model. We detected 3-(3,4-dihydroxyphenyl)propionic acid in fecal samples of Parkinson's disease patients on levodopa medication and found that this metabolite is actively produced by the gut microbiota in those stool samples. CONCLUSIONS:Levodopa is deaminated by the gut bacterium C. sporogenes producing a metabolite that inhibits ileal motility ex vivo. Overall, this study underpins the importance of the metabolic pathways of the gut microbiome involved in drug metabolism not only to preserve drug effectiveness, but also to avoid potential side effects of bacterial breakdown products of the unabsorbed residue of medication.
journal_name
BMC Bioljournal_title
BMC biologyauthors
van Kessel SP,de Jong HR,Winkel SL,van Leeuwen SS,Nelemans SA,Permentier H,Keshavarzian A,El Aidy Sdoi
10.1186/s12915-020-00876-3subject
Has Abstractpub_date
2020-10-20 00:00:00pages
137issue
1issn
1741-7007pii
10.1186/s12915-020-00876-3journal_volume
18pub_type
杂志文章相关文献
BMC BIOLOGY文献大全abstract：BACKGROUND:Accurate determination of mouse positions from video data is crucial for various types of behavioral analyses. While detection of body positions is straightforward, the correct identification of nose positions, usually more informative, is far more challenging. The difficulty is largely due to variability in...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-017-0377-3
更新日期：2017-05-15 00:00:00
abstract：BACKGROUND:Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of standardized a...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-9-38
更新日期：2011-06-02 00:00:00
abstract：BACKGROUND:Gene drives based on CRISPR-Cas9 technology are increasingly being considered as tools for reducing the capacity of mosquito populations to transmit malaria, and one of the most promising options is driving endonuclease genes that reduce the fertility of female mosquitoes. In particular, there is much intere...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00834-z
更新日期：2020-08-11 00:00:00
abstract：:The majority of convincingly documented cases of hybridization in angiosperms has involved genetic introgression between the parental species or formation of a hybrid species with increased ploidy; however, homoploid (diploid) hybridization may be just as common. Recent studies, including one in BMC Evolutionary Biolo...
journal_title：BMC biology
pub_type： 社论
doi：10.1186/1741-7007-8-45
更新日期：2010-04-21 00:00:00
abstract：BACKGROUND:The ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is intimately linked to gene regulation, much less is known about the...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-7-43
更新日期：2009-07-23 00:00:00
abstract：BACKGROUND:The red algae (Rhodophyta) diverged from the green algae and plants (Viridiplantae) over one billion years ago within the kingdom Archaeplastida. These photosynthetic lineages provide an ideal model to study plastid genome reduction in deep time. To this end, we assembled a large dataset of the plastid genom...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0299-5
更新日期：2016-09-02 00:00:00
abstract：:The expansion of genome sequencing projects has produced accumulating evidence for lateral transfer of genes between prokaryotic and eukaryotic genomes. However, it remains controversial whether these genes are of functional importance in their recipient host. Nikoh and Nakabachi, in a recent paper in BMC Biology, tak...
journal_title：BMC biology
pub_type： 评论,杂志文章
doi：10.1186/1741-7007-7-20
更新日期：2009-05-05 00:00:00
abstract：BACKGROUND:Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, which triggers the induction of a subset of P. aeruginosa-response genes in the nematode Caenorhabdit...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0334-6
更新日期：2016-12-07 00:00:00
abstract：BACKGROUND:O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investi...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-6-1
更新日期：2008-01-14 00:00:00
abstract：BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0715-8
更新日期：2019-11-27 00:00:00
abstract：BACKGROUND:Although a variety of animals have been used to produce polyclonal antibodies against antigens, the production of antigen-specific monoclonal antibodies from animals remains challenging. RESULTS:We propose a simple and rapid strategy to produce monoclonal antibodies from a variety of animals. By staining ly...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-10-80
更新日期：2012-09-28 00:00:00
abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...
journal_title：BMC biology
pub_type： 社论
doi：10.1186/1741-7007-9-88
更新日期：2011-12-28 00:00:00
abstract：BACKGROUND:Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development. Conversely, trithorax-group (trxG) genes encode positive factors required for maintenance of long term Hox gene activation. Both kinds of factors bind chromatin regions called maintenance elements ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-9
更新日期：2006-04-14 00:00:00
abstract：BACKGROUND:Sexual reproduction entails the encounter of the sexes and the multiplicity of rituals is parallel to the diversity of mating systems. Evolutionary mechanisms such as sexual selection and sexual conflict have led to the elaboration of traits to gain attention and favours from potential partners. A paradox ex...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-7-10
更新日期：2009-03-03 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-34
更新日期：2006-10-12 00:00:00
abstract：BACKGROUND:The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd gen...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-12-12
更新日期：2014-02-14 00:00:00
abstract：BACKGROUND:Animal olfactory systems detect volatile environmental chemicals and integrate this information to direct the discovery of food and mates as well as danger avoidance. Rather than remaining constant, olfactory response thresholds are modulated by internal and external cues to adapt odor-guided behaviors to ch...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-017-0374-6
更新日期：2017-05-05 00:00:00
abstract：BACKGROUND:Vertebrates are characterized by possession of hypobranchial muscles (HBMs). Cyclostomes, or modern jawless vertebrates, possess a rudimentary and superficial HBM lateral to the pharynx, whereas the HBM in jawed vertebrates is internalized and anteroposteriorly specified. Precursor cells of the HBM, marked b...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00851-y
更新日期：2020-09-09 00:00:00
abstract：:The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiqu...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/s12915-017-0449-4
更新日期：2017-11-16 00:00:00
abstract：:Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection. Here, we explore the roles of mitochondrial autophagy (mitophag...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/s12915-015-0129-1
更新日期：2015-04-03 00:00:00
abstract：BACKGROUND:The western flower thrips, Frankliniella occidentalis (Pergande), is a globally invasive pest and plant virus vector on a wide array of food, fiber, and ornamental crops. The underlying genetic mechanisms of the processes governing thrips pest and vector biology, feeding behaviors, ecology, and insecticide r...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00862-9
更新日期：2020-10-19 00:00:00
abstract：:The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, th...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/1741-7007-11-96
更新日期：2013-09-03 00:00:00
abstract：:Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core molecular elements of the ethylene-signaling pathway have been uncovered, re...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0230-0
更新日期：2016-01-27 00:00:00
abstract：BACKGROUND:Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-11-93
更新日期：2013-08-19 00:00:00
abstract：BACKGROUND:Nucleostemin is a nucleolus residing GTPase that is considered to be an important cancer stem/progenitor cell marker protein due to its high expression levels in breast cancer stem cells and its role in tumor-initiation of human mammary tumor cells. It has been proposed that nucleostemin may represent a valu...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-014-0072-6
更新日期：2014-09-12 00:00:00
abstract：:Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent paper in BMC Systems Biology describes a promising step in this direction. ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-8-48
更新日期：2010-04-28 00:00:00
abstract：BACKGROUND:Sec8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function, including neurite outgrowth, calcium-dependent neurotransmitter secretion, trafficking of ionotropic glutamate receptors and regulation of neuronal microtubule ass...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-3-27
更新日期：2005-12-13 00:00:00
abstract：BACKGROUND:Pneumococcal meningitis is associated with high mortality (approximately 30%) and morbidity. Up to 50% of survivors are affected by neurological sequelae due to a wide spectrum of brain injury mainly affecting the cortex and hippocampus. Despite this significant disease burden, the genetic program that regul...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-15
更新日期：2006-06-02 00:00:00
abstract：:A common symbiont of insects, the bacterium Wolbachia has been implicated in phenomena as diverse as sex determination, pathogen defence and speciation and is being used in public health programs to prevent mosquitoes transmitting disease. Despite decades of research, we know remarkably little about how it exerts its ...
journal_title：BMC biology
pub_type： 社论
doi：10.1186/s12915-016-0312-z
更新日期：2016-10-19 00:00:00
abstract：:The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology, demonstrate through phylogenetic analysis of the CCA1/LHY and TOC1/PRR gene families that the common ancestor of monocots and eudicots had compone...
journal_title：BMC biology
pub_type： 评论,杂志文章,评审
doi：10.1186/1741-7007-8-55
更新日期：2010-05-07 00:00:00
