Abstract：
:The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiquitin-proteasome or autophagy pathway. Stress response pathway induction is also important for cancer cell survival. Indeed, validated targets for anti-cancer treatments include molecular chaperones, components of the unfolded protein response, the ubiquitin-proteasome system, and autophagy. We will focus on links between breast cancer and these processes, as well as the development of drug resistance, relapse, and treatment.
journal_name
BMC Bioljournal_title
BMC biologyauthors
Sannino S,Brodsky JLdoi
10.1186/s12915-017-0449-4subject
Has Abstractpub_date
2017-11-16 00:00:00pages
109issue
1issn
1741-7007pii
10.1186/s12915-017-0449-4journal_volume
15pub_type
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