Network integration meets network dynamics.

abstract：BACKGROUND:Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, which triggers the induction of a subset of P. aeruginosa-response genes in the nematode Caenorhabdit...

journal_title：BMC biology

authors： McEwan DL,Feinbaum RL,Stroustrup N,Haas W,Conery AL,Anselmo A,Sadreyev R,Ausubel FM

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Gene drives based on CRISPR-Cas9 technology are increasingly being considered as tools for reducing the capacity of mosquito populations to transmit malaria, and one of the most promising options is driving endonuclease genes that reduce the fertility of female mosquitoes. In particular, there is much intere...

journal_title：BMC biology

authors： North AR,Burt A,Godfray HCJ

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd gen...

journal_title：BMC biology

authors： Ignesti M,Barraco M,Nallamothu G,Woolworth JA,Duchi S,Gargiulo G,Cavaliere V,Hsu T

更新日期：2014-02-14 00:00:00

abstract：:The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the 'micro-circuitry' of this highly organized midbrain structure filters visual input, which arrives in the supe...

journal_title：BMC biology

authors： Nevin LM,Robles E,Baier H,Scott EK

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Mate choice is of central importance to most animals, influencing population structure, speciation, and ultimately the survival of a species. Mating behavior of male brachionid rotifers is triggered by the product of a chemosensory gene, a glycoprotein on the body surface of females called the mate recogniti...

journal_title：BMC biology

authors： Snell TW,Shearer TL,Smith HA,Kubanek J,Gribble KE,Welch DB

更新日期：2009-09-09 00:00:00

abstract：BACKGROUND:The availability of abundant sequence data from key model organisms has made large scale studies of molecular evolution an exciting possibility. Here we use full length cDNA alignments comprising more than 700,000 nucleotides from human, mouse, pig and the Japanese pufferfish Fugu rubrices in order to invest...

journal_title：BMC biology

authors： Jørgensen FG,Hobolth A,Hornshøj H,Bendixen C,Fredholm M,Schierup MH

更新日期：2005-01-28 00:00:00

abstract：BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...

journal_title：BMC biology

authors： Le Roy T,Lécuyer E,Chassaing B,Rhimi M,Lhomme M,Boudebbouze S,Ichou F,Haro Barceló J,Huby T,Guerin M,Giral P,Maguin E,Kapel N,Gérard P,Clément K,Lesnik P

更新日期：2019-11-27 00:00:00

abstract：:Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core molecular elements of the ethylene-signaling pathway have been uncovered, re...

journal_title：BMC biology

authors： Chang C

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic te...

journal_title：BMC biology

authors： Fuchs S,Bundy JG,Davies SK,Viney JM,Swire JS,Leroi AM

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development. Conversely, trithorax-group (trxG) genes encode positive factors required for maintenance of long term Hox gene activation. Both kinds of factors bind chromatin regions called maintenance elements ...

journal_title：BMC biology

authors： Salvaing J,Decoville M,Mouchel-Vielh E,Bussière M,Daulny A,Boldyreva L,Zhimulev I,Locker D,Peronnet F

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...

journal_title：BMC biology

authors： Beckmann A,Xiao S,Müller JP,Mercadante D,Nüchter T,Kröger N,Langhojer F,Petrich W,Holstein TW,Benoit M,Gräter F,Özbek S

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Early developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highly derived life cycles involving indirect development, and even the true orientation of the tapeworm antero-posterior (AP) axis...

journal_title：BMC biology

authors： Koziol U,Jarero F,Olson PD,Brehm K

更新日期：2016-03-04 00:00:00

abstract：BACKGROUND:Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identities have been assigned to all neurons, the number of annotatable neurons in an intact animal has...

journal_title：BMC biology

authors： Toyoshima Y,Wu S,Kanamori M,Sato H,Jang MS,Oe S,Murakami Y,Teramoto T,Park C,Iwasaki Y,Ishihara T,Yoshida R,Iino Y

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Nucleolar rDNA is tightly associated with silent heterochromatin, which is important for rDNA stability, nucleolar integration, and cellular senescence. Two pathways have been described that lead to rDNA silencing in yeast: 1) the RENT (regulator of nucleolar silencing and telophase exit) complex, which is c...

journal_title：BMC biology

authors： Ryu HY,Ahn S

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...

journal_title：BMC biology

authors： Sunagar K,Columbus-Shenkar YY,Fridrich A,Gutkovich N,Aharoni R,Moran Y

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identification of protein complexes by AP/MS is complicated by the potential heterogeneity of complexes in different tissues. Here, we...

journal_title：BMC biology

authors： Waaijers S,Muñoz J,Berends C,Ramalho JJ,Goerdayal SS,Low TY,Zoumaro-Djayoon AD,Hoffmann M,Koorman T,Tas RP,Harterink M,Seelk S,Kerver J,Hoogenraad CC,Bossinger O,Tursun B,van den Heuvel S,Heck AJ,Boxem M

更新日期：2016-08-09 00:00:00

abstract：:The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mou...

journal_title：BMC biology

authors： Bell G

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...

journal_title：BMC biology

authors： Huminiecki L,Heldin CH

更新日期：2010-12-13 00:00:00

abstract：BACKGROUND:For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been proposed on their basis. However, the difficulty in investigating complex I semiquinones, due to the...

journal_title：BMC biology

authors： Wright JJ,Fedor JG,Hirst J,Roessler MM

更新日期：2020-05-20 00:00:00

abstract：:This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding sites, the enhancement of traditional virtual-screening methodolog...

journal_title：BMC biology

authors： Durrant JD,McCammon JA

更新日期：2011-10-28 00:00:00

abstract：:Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell-cell communication and the transmission of disease states, and explored as a means of drug discovery. Yet fundamental questions about their biology remain unanswered. Here I explore what exosomes are, highlight the di...

journal_title：BMC biology

authors： Edgar JR

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Seed plants are composed of angiosperms and gymnosperms, which diverged from each other around 300 million years ago. While much light has been shed on the mechanisms and rate of genome evolution in flowering plants, such knowledge remains conspicuously meagre for the gymnosperms. Conifers are key representa...

journal_title：BMC biology

authors： Pavy N,Pelgas B,Laroche J,Rigault P,Isabel N,Bousquet J

更新日期：2012-10-26 00:00:00

abstract：BACKGROUND:Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epithelial cells are relatively well studied, molecular markers of lung mesenchymal cells and the genetic...

journal_title：BMC biology

authors： Zhang W,Menke DB,Jiang M,Chen H,Warburton D,Turcatel G,Lu CH,Xu W,Luo Y,Shi W

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (AC...

journal_title：BMC biology

authors： Kloehn J,Oppenheim RD,Siddiqui G,De Bock PJ,Kumar Dogga S,Coute Y,Hakimi MA,Creek DJ,Soldati-Favre D

更新日期：2020-06-16 00:00:00

abstract：:A recent paper published in BMC Genomics suggests that retrotransposition may be active in the human gut parasite Entamoeba histolytica. This adds to our knowledge of the various types of repetitive elements in parasitic protists and the potential influence of such elements on pathogenicity. ...

journal_title：BMC biology

authors： Clayton C

更新日期：2010-05-24 00:00:00

abstract：BACKGROUND:Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species a...

journal_title：BMC biology

authors： Päivinen J,Grapputo A,Kaitala V,Komonen A,Kotiaho JS,Saarinen K,Wahlberg N

更新日期：2005-03-01 00:00:00

abstract：:Animal domestication has fascinated biologists since Charles Darwin first drew the parallel between evolution via natural selection and human-mediated breeding of livestock and companion animals. In this review we show how studies of ancient DNA from domestic animals and their wild progenitors and congeners have shed ...

journal_title：BMC biology

authors： McHugo GP,Dover MJ,MacHugh DE

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as reservoirs of resistance genes for human pathogens. Anthropogenic activity may contribute to the sp...

journal_title：BMC biology

authors： Marcelino VR,Wille M,Hurt AC,González-Acuña D,Klaassen M,Schlub TE,Eden JS,Shi M,Iredell JR,Sorrell TC,Holmes EC

更新日期：2019-04-08 00:00:00

abstract：:Joel Dacks is an Associate Professor and Canada Research Chair in Evolutionary Cell Biology at the University of Alberta, a Scientific Associate at the Natural History Museum (London), and the current President of the International Society for Evolutionary Protistology. His research group studies the evolution and div...

journal_title：BMC biology

authors： Dacks JB

更新日期：2018-11-01 00:00:00