Focusing on optic tectum circuitry through the lens of genetics.

abstract：BACKGROUND:Loss of photosynthesis has occurred independently in several plant and algal lineages, and represents a major metabolic shift with potential consequences for the content and structure of plastid genomes. To investigate such changes, we sequenced the complete plastid genome of the parasitic, non-photosyntheti...

journal_title：BMC biology

authors： de Koning AP,Keeling PJ

更新日期：2006-04-21 00:00:00

abstract：BACKGROUND:Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (AC...

journal_title：BMC biology

authors： Kloehn J,Oppenheim RD,Siddiqui G,De Bock PJ,Kumar Dogga S,Coute Y,Hakimi MA,Creek DJ,Soldati-Favre D

更新日期：2020-06-16 00:00:00

abstract：:Cells are highly complex and orderly machines, with defined shapes and a startling variety of internal organizations. Complex geometry is a feature of both free-living unicellular organisms and cells inside multicellular animals. Where does the geometry of a cell come from? Many of the same questions that arise in dev...

journal_title：BMC biology

authors： Marshall WF

更新日期：2011-08-31 00:00:00

abstract：BACKGROUND:Microarray analysis and 454 cDNA sequencing were used to investigate a centuries-old problem in regenerative biology: the basis of nerve-dependent limb regeneration in salamanders. Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14...

journal_title：BMC biology

authors： Monaghan JR,Epp LG,Putta S,Page RB,Walker JA,Beachy CK,Zhu W,Pao GM,Verma IM,Hunter T,Bryant SV,Gardiner DM,Harkins TT,Voss SR

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain is also elicited by natural rewards and incentive cues, raising the possibility that some CRF systems in the brain mediate an independent function of positiv...

journal_title：BMC biology

authors： Peciña S,Schulkin J,Berridge KC

更新日期：2006-04-13 00:00:00

abstract：:This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding sites, the enhancement of traditional virtual-screening methodolog...

journal_title：BMC biology

authors： Durrant JD,McCammon JA

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:Nucleostemin is a nucleolus residing GTPase that is considered to be an important cancer stem/progenitor cell marker protein due to its high expression levels in breast cancer stem cells and its role in tumor-initiation of human mammary tumor cells. It has been proposed that nucleostemin may represent a valu...

journal_title：BMC biology

authors： Tin AS,Park AH,Sundar SN,Firestone GL

更新日期：2014-09-12 00:00:00

abstract：BACKGROUND:The availability of abundant sequence data from key model organisms has made large scale studies of molecular evolution an exciting possibility. Here we use full length cDNA alignments comprising more than 700,000 nucleotides from human, mouse, pig and the Japanese pufferfish Fugu rubrices in order to invest...

journal_title：BMC biology

authors： Jørgensen FG,Hobolth A,Hornshøj H,Bendixen C,Fredholm M,Schierup MH

更新日期：2005-01-28 00:00:00

abstract：:The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in mediating these responses. See research article http://www.biomedcentra...

journal_title：BMC biology

authors： Whitmarsh AJ

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all...

journal_title：BMC biology

authors： Volkers RJ,Snoek LB,Hubar CJ,Coopman R,Chen W,Yang W,Sterken MG,Schulenburg H,Braeckman BP,Kammenga JE

更新日期：2013-08-19 00:00:00

abstract：BACKGROUND:Mate choice is of central importance to most animals, influencing population structure, speciation, and ultimately the survival of a species. Mating behavior of male brachionid rotifers is triggered by the product of a chemosensory gene, a glycoprotein on the body surface of females called the mate recogniti...

journal_title：BMC biology

authors： Snell TW,Shearer TL,Smith HA,Kubanek J,Gribble KE,Welch DB

更新日期：2009-09-09 00:00:00

abstract：BACKGROUND:mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS:As a proof of principle, we show in both cell lines and primary cell cultu...

journal_title：BMC biology

authors： Bouquier N,Moutin E,Tintignac LA,Reverbel A,Jublanc E,Sinnreich M,Chastagnier Y,Averous J,Fafournoux P,Verpelli C,Boeckers T,Carnac G,Perroy J,Ollendorff V

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that influenza reassortment not only contributes to the emergence of new human pandemics but also plays an important role in seasonal influenza epidemics, disease severity, evolution, and vaccine efficacy. We studied this process within 2091 H3N2 full genomes utilizing a combinat...

journal_title：BMC biology

authors： Maljkovic Berry I,Melendrez MC,Li T,Hawksworth AW,Brice GT,Blair PJ,Halsey ES,Williams M,Fernandez S,Yoon IK,Edwards LD,Kuschner R,Lin X,Thomas SJ,Jarman RG

更新日期：2016-12-29 00:00:00

abstract：BACKGROUND:Eukaryotic genome assembly remains a challenge in part due to the prevalence of complex DNA repeats. This is a particularly acute problem for holocentric nematodes because of the large number of satellite DNA sequences found throughout their genomes. These have been recalcitrant to most genome sequencing met...

journal_title：BMC biology

authors： Eccles D,Chandler J,Camberis M,Henrissat B,Koren S,Le Gros G,Ewbank JJ

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (CI) in infected mosquitoes. Species in the Culex pipiens complex display an unusually high number ...

journal_title：BMC biology

authors： Walker T,Klasson L,Sebaihia M,Sanders MJ,Thomson NR,Parkhill J,Sinkins SP

更新日期：2007-09-20 00:00:00

abstract：BACKGROUND:Conservation of the spatial binding organizations at the level of physico-chemical interactions is important for the formation and stability of protein-protein complexes as well as protein and drug design. Due to the lack of computational tools for recognition of spatial patterns of interactions shared by a ...

journal_title：BMC biology

authors： Shulman-Peleg A,Shatsky M,Nussinov R,Wolfson HJ

更新日期：2007-10-09 00:00:00

abstract：BACKGROUND:The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant ...

journal_title：BMC biology

authors： Boursereau R,Abou-Samra M,Lecompte S,Noel L,Brichard SM

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enormously to the subsistence and socio-cultural lives of millions of people, principally in West and ...

journal_title：BMC biology

authors： Tamiru M,Natsume S,Takagi H,White B,Yaegashi H,Shimizu M,Yoshida K,Uemura A,Oikawa K,Abe A,Urasaki N,Matsumura H,Babil P,Yamanaka S,Matsumoto R,Muranaka S,Girma G,Lopez-Montes A,Gedil M,Bhattacharjee R,Abberton M

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Insects helped pioneer, and persist as model organisms for, the study of specific aspects of immunity. Although they lack an adaptive immune system, insects possess an innate immune system that recognizes and destroys intruding microorganisms. Its operation under natural conditions has not been well studied,...

journal_title：BMC biology

authors： Freitak D,Wheat CW,Heckel DG,Vogel H

更新日期：2007-12-21 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：:The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology, demonstrate through phylogenetic analysis of the CCA1/LHY and TOC1/PRR gene families that the common ancestor of monocots and eudicots had compone...

journal_title：BMC biology

authors： McClung CR

更新日期：2010-05-07 00:00:00

abstract：BACKGROUND:Drosophila melanogaster has served as a powerful model system for genetic studies of courtship songs. To accelerate research on the genetic and neural mechanisms underlying courtship song, we have developed a sensitive recording system to simultaneously capture the acoustic signals from 32 separate pairs of ...

journal_title：BMC biology

authors： Arthur BJ,Sunayama-Morita T,Coen P,Murthy M,Stern DL

更新日期：2013-01-31 00:00:00

abstract：:Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic...

journal_title：BMC biology

authors： Rappuoli R

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of standardized a...

journal_title：BMC biology

authors： Hundeshagen P,Hamacher-Brady A,Eils R,Brady NR

更新日期：2011-06-02 00:00:00

abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...

journal_title：BMC biology

authors： Ely B,Wilson JL,Jackson F,Jackson BA

更新日期：2006-10-12 00:00:00

abstract：:Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...

journal_title：BMC biology

authors： Keller A

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins. RESULTS:Here we mined the human proteome and identified the membrane proteome subset using three prediction tools for alpha-hel...

journal_title：BMC biology

authors： Almén MS,Nordström KJ,Fredriksson R,Schiöth HB

更新日期：2009-08-13 00:00:00

abstract：:A recent paper in BMC Structural Biology reports the crystal structure of human prolylcarboxypeptidase (PRCP), one of the two members of the S28 peptidase family. Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic ...

journal_title：BMC biology

authors： Kozarich JW

更新日期：2010-06-28 00:00:00

abstract：BACKGROUND:TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors. RES...

journal_title：BMC biology

authors： Lammirato A,Patsch K,Feiereisen F,Maly K,Nofziger C,Paulmichl M,Hackl H,Trajanoski Z,Valovka T,Huber LA,Vietor I

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:Dorsal spine reduction in threespine sticklebacks (Gasterosteus aculeatus) is a classic example of recurrent skeletal evolution in nature. Sticklebacks in marine environments typically have long spines that form part of their skeletal armor. Many derived freshwater populations have evolved shorter spines. Ch...

journal_title：BMC biology

authors： Howes TR,Summers BR,Kingsley DM

更新日期：2017-12-07 00:00:00