Abstract：
BACKGROUND:Drosophila melanogaster has served as a powerful model system for genetic studies of courtship songs. To accelerate research on the genetic and neural mechanisms underlying courtship song, we have developed a sensitive recording system to simultaneously capture the acoustic signals from 32 separate pairs of courting flies as well as software for automated segmentation of songs. RESULTS:Our novel hardware design enables recording of low amplitude sounds in most laboratory environments. We demonstrate the power of this system by collecting, segmenting and analyzing over 18 hours of courtship song from 75 males from five wild-type strains of Drosophila melanogaster. Our analysis reveals previously undetected modulation of courtship song features and extensive natural genetic variation for most components of courtship song. Despite having a large dataset with sufficient power to detect subtle modulations of song, we were unable to identify previously reported periodic rhythms in the inter-pulse interval of song. We provide detailed instructions for assembling the hardware and for using our open-source segmentation software. CONCLUSIONS:Analysis of a large dataset of acoustic signals from Drosophila melanogaster provides novel insight into the structure and dynamics of species-specific courtship songs. Our new system for recording and analyzing fly acoustic signals should therefore greatly accelerate future studies of the genetics, neurobiology and evolution of courtship song.
journal_name
BMC Bioljournal_title
BMC biologyauthors
Arthur BJ,Sunayama-Morita T,Coen P,Murthy M,Stern DLdoi
10.1186/1741-7007-11-11subject
Has Abstractpub_date
2013-01-31 00:00:00pages
11issn
1741-7007pii
1741-7007-11-11journal_volume
11pub_type
杂志文章相关文献
BMC BIOLOGY文献大全abstract：BACKGROUND:Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species a...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-3-5
更新日期：2005-03-01 00:00:00
abstract：:Animal domestication has fascinated biologists since Charles Darwin first drew the parallel between evolution via natural selection and human-mediated breeding of livestock and companion animals. In this review we show how studies of ancient DNA from domestic animals and their wild progenitors and congeners have shed ...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/s12915-019-0724-7
更新日期：2019-12-02 00:00:00
abstract：BACKGROUND:O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investi...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-6-1
更新日期：2008-01-14 00:00:00
abstract：:The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or ch...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-10-35
更新日期：2012-04-24 00:00:00
abstract：BACKGROUND:The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a drivi...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0645-5
更新日期：2019-03-29 00:00:00
abstract：BACKGROUND:For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been proposed on their basis. However, the difficulty in investigating complex I semiquinones, due to the...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00768-6
更新日期：2020-05-20 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-34
更新日期：2006-10-12 00:00:00
abstract：BACKGROUND:mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS:As a proof of principle, we show in both cell lines and primary cell cultu...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00790-8
更新日期：2020-07-03 00:00:00
abstract：BACKGROUND:Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0609-1
更新日期：2018-11-20 00:00:00
abstract：:The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mou...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0254-5
更新日期：2016-04-07 00:00:00
abstract：:In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent ...
journal_title：BMC biology
pub_type： 社论
doi：10.1186/1741-7007-10-48
更新日期：2012-06-13 00:00:00
abstract：:The vertebrate nervous system is deeply divided into 'somatic' and 'visceral' subsystems that respond to external and internal stimuli, respectively. Molecular characterization of neurons in different groups of mollusks by Nomaksteinsky and colleagues, published in this issue of BMC Biology, reveals that the viscero-s...
journal_title：BMC biology
pub_type： 评论,杂志文章
doi：10.1186/1741-7007-11-54
更新日期：2013-04-30 00:00:00
abstract：:The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology, demonstrate through phylogenetic analysis of the CCA1/LHY and TOC1/PRR gene families that the common ancestor of monocots and eudicots had compone...
journal_title：BMC biology
pub_type： 评论,杂志文章,评审
doi：10.1186/1741-7007-8-55
更新日期：2010-05-07 00:00:00
abstract：BACKGROUND:Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embedded in the gene regulatory networks that orchestrate embryogenesis. Knotted-like homeobox (KNOX) TF...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0605-5
更新日期：2018-11-05 00:00:00
abstract：:Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent paper in BMC Systems Biology describes a promising step in this direction. ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-8-48
更新日期：2010-04-28 00:00:00
abstract：BACKGROUND:Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enormously to the subsistence and socio-cultural lives of millions of people, principally in West and ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-017-0419-x
更新日期：2017-09-19 00:00:00
abstract：BACKGROUND:Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Ye...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-015-0176-7
更新日期：2015-08-25 00:00:00
abstract：BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-014-0113-1
更新日期：2015-01-16 00:00:00
abstract：BACKGROUND:The red algae (Rhodophyta) diverged from the green algae and plants (Viridiplantae) over one billion years ago within the kingdom Archaeplastida. These photosynthetic lineages provide an ideal model to study plastid genome reduction in deep time. To this end, we assembled a large dataset of the plastid genom...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0299-5
更新日期：2016-09-02 00:00:00
abstract：:Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...
journal_title：BMC biology
pub_type： 评论,杂志文章
doi：10.1186/1741-7007-10-75
更新日期：2012-08-21 00:00:00
abstract：BACKGROUND:Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system. RESULTS:Adult Spragu...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-7-31
更新日期：2009-06-17 00:00:00
abstract：BACKGROUND:CRISPR gene drive systems allow the rapid spread of a genetic construct throughout a population. Such systems promise novel strategies for the management of vector-borne diseases and invasive species by suppressing a target population or modifying it with a desired trait. However, current homing-type drives ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-0761-2
更新日期：2020-03-12 00:00:00
abstract：BACKGROUND:ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III filam...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0700-2
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic te...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-8-14
更新日期：2010-02-10 00:00:00
abstract：BACKGROUND:Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mi...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-015-0221-6
更新日期：2015-12-22 00:00:00
abstract：BACKGROUND:Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identification of protein complexes by AP/MS is complicated by the potential heterogeneity of complexes in different tissues. Here, we...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0286-x
更新日期：2016-08-09 00:00:00
abstract：BACKGROUND:Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate proteins. A diffe...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-017-0445-8
更新日期：2017-11-08 00:00:00
abstract：BACKGROUND:The internal organization of cells depends on mechanisms to ensure that transport carriers, such as vesicles, fuse only with the correct destination organelle. Several types of proteins have been proposed to confer specificity to this process, and we have recently shown that a set of coiled-coil proteins on ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0345-3
更新日期：2017-01-26 00:00:00
abstract：BACKGROUND:Although a variety of animals have been used to produce polyclonal antibodies against antigens, the production of antigen-specific monoclonal antibodies from animals remains challenging. RESULTS:We propose a simple and rapid strategy to produce monoclonal antibodies from a variety of animals. By staining ly...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-10-80
更新日期：2012-09-28 00:00:00
abstract：BACKGROUND:Dorsal spine reduction in threespine sticklebacks (Gasterosteus aculeatus) is a classic example of recurrent skeletal evolution in nature. Sticklebacks in marine environments typically have long spines that form part of their skeletal armor. Many derived freshwater populations have evolved shorter spines. Ch...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-017-0456-5
更新日期：2017-12-07 00:00:00
