Abstract：
:The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mouse compared with the control. The results are reported as statistically significant, with impressive 'n' values in each condition: the authors say that n = 7 in each case. They confidently conclude that the level of each of the three proteins is increased in the knockout mutant.
journal_name
BMC Bioljournal_title
BMC biologyauthors
Bell Gdoi
10.1186/s12915-016-0254-5subject
Has Abstractpub_date
2016-04-07 00:00:00pages
28issn
1741-7007pii
10.1186/s12915-016-0254-5journal_volume
14pub_type
杂志文章相关文献
BMC BIOLOGY文献大全abstract：BACKGROUND:Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the polyploid nature, high genome complexity and lack of genomic sequence integration with reproductive tiss...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0311-0
更新日期：2016-10-06 00:00:00
abstract：BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-8-142
更新日期：2010-11-30 00:00:00
abstract：:There are many reasons to be interested in stem cells, one of the most prominent being their potential use in finding better drugs to treat human disease. This article focuses on how this may be implemented. Recent advances in the production of reprogrammed adult cells and their regulated differentiation to disease-re...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/1741-7007-9-42
更新日期：2011-06-07 00:00:00
abstract：BACKGROUND:Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the number of non-coding RNAs identified in various organisms. While we have mechanistic underst...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0635-7
更新日期：2019-02-18 00:00:00
abstract：BACKGROUND:The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experience-dependent transgenerational inheritance. However, questions remain unanswered as to how heritabl...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00780-w
更新日期：2020-04-30 00:00:00
abstract：BACKGROUND:A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents. METHODS:Here, we translated the EPM to humans using mixed reality through a co...
journal_title：BMC biology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12915-017-0463-6
更新日期：2017-12-21 00:00:00
abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-8-146
更新日期：2010-12-13 00:00:00
abstract：BACKGROUND:Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain is also elicited by natural rewards and incentive cues, raising the possibility that some CRF systems in the brain mediate an independent function of positiv...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-8
更新日期：2006-04-13 00:00:00
abstract：BACKGROUND:The processes by which eggs develop in the insect ovary are well characterized. Despite a large number of Drosophila mutants that cannot lay eggs, the way that the egg is moved along the reproductive tract from ovary to uterus is less well understood. We remedy this with an integrative study on the reproduct...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-17
更新日期：2006-06-12 00:00:00
abstract：BACKGROUND:Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is not reversible. A number of methods have been developed to overcome this, but each method has its own limitations. RESULTS:We d...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-10-96
更新日期：2012-11-30 00:00:00
abstract：BACKGROUND:Archaeological studies have revealed a series of cultural changes around the Last Glacial Maximum in East Asia; whether these changes left any signatures in the gene pool of East Asians remains poorly indicated. To achieve deeper insights into the demographic history of modern humans in East Asia around the ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-9-2
更新日期：2011-01-10 00:00:00
abstract：BACKGROUND:Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes. Inactivating single oncogenes, such as c-Myc, can reverse even advanced tumours. Intrigui...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-2-26
更新日期：2004-12-21 00:00:00
abstract：BACKGROUND:Regulatory T cells (Tregs) expressing the transcription factor FOXP3 are crucial mediators of self-tolerance, preventing autoimmune diseases but possibly hampering tumor rejection. Clinical manipulation of Tregs is of great interest, and first-in-man trials of Treg transfer have achieved promising outcomes. ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0518-3
更新日期：2018-05-07 00:00:00
abstract：BACKGROUND:The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal muscles of patients ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00767-7
更新日期：2020-03-26 00:00:00
abstract：BACKGROUND:Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epithelial cells are relatively well studied, molecular markers of lung mesenchymal cells and the genetic...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-11-111
更新日期：2013-11-13 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-34
更新日期：2006-10-12 00:00:00
abstract：BACKGROUND:Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species a...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-3-5
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. RESULTS:By exploring the possible effects of v...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-015-0122-8
更新日期：2015-02-19 00:00:00
abstract：BACKGROUND:Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Ye...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-015-0176-7
更新日期：2015-08-25 00:00:00
abstract：:The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, th...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/1741-7007-11-96
更新日期：2013-09-03 00:00:00
abstract：BACKGROUND:Kinases mTORC1 and AMPK act as energy sensors, controlling nutrient responses and cellular growth. Changes in nutrient levels affect diverse transcriptional networks, making it challenging to identify downstream paths that regulate cellular growth or a switch to development via nutrient variation. The life c...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0673-1
更新日期：2019-07-18 00:00:00
abstract：BACKGROUND:Cellular functions can be regulated by cell-cell interactions that are influenced by extra-cellular, density-dependent signaling factors. Dictyostelium grow as individual cells in nutrient-rich sources, but, as nutrients become depleted, they initiate a multi-cell developmental program that is dependent upon...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0714-9
更新日期：2019-12-02 00:00:00
abstract：BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0633-9
更新日期：2019-02-22 00:00:00
abstract：BACKGROUND:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracti...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00876-3
更新日期：2020-10-20 00:00:00
abstract：:Cells are highly complex and orderly machines, with defined shapes and a startling variety of internal organizations. Complex geometry is a feature of both free-living unicellular organisms and cells inside multicellular animals. Where does the geometry of a cell come from? Many of the same questions that arise in dev...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-9-57
更新日期：2011-08-31 00:00:00
abstract：BACKGROUND:Within chromatin, the histone variant H2A.Z plays a role in many diverse nuclear processes including transcription, preventing the spread of heterochromatin and epigenetic transcriptional memory. The molecular mechanisms of how H2A.Z mediates its effects are not entirely understood. However, it is now known ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-7-86
更新日期：2009-12-14 00:00:00
abstract：:The vertebrate nervous system is deeply divided into 'somatic' and 'visceral' subsystems that respond to external and internal stimuli, respectively. Molecular characterization of neurons in different groups of mollusks by Nomaksteinsky and colleagues, published in this issue of BMC Biology, reveals that the viscero-s...
journal_title：BMC biology
pub_type： 评论,杂志文章
doi：10.1186/1741-7007-11-54
更新日期：2013-04-30 00:00:00
abstract：BACKGROUND:Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (CI) in infected mosquitoes. Species in the Culex pipiens complex display an unusually high number ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-5-39
更新日期：2007-09-20 00:00:00
abstract：BACKGROUND:Early developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highly derived life cycles involving indirect development, and even the true orientation of the tapeworm antero-posterior (AP) axis...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0233-x
更新日期：2016-03-04 00:00:00
abstract：:The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiqu...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/s12915-017-0449-4
更新日期：2017-11-16 00:00:00
