mTORC1/AMPK responses define a core gene set for developmental cell fate switching.

abstract：BACKGROUND:Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate proteins. A diffe...

journal_title：BMC biology

authors： Peleh V,Zannini F,Backes S,Rouhier N,Herrmann JM

更新日期：2017-11-08 00:00:00

abstract：BACKGROUND:Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identities have been assigned to all neurons, the number of annotatable neurons in an intact animal has...

journal_title：BMC biology

authors： Toyoshima Y,Wu S,Kanamori M,Sato H,Jang MS,Oe S,Murakami Y,Teramoto T,Park C,Iwasaki Y,Ishihara T,Yoshida R,Iino Y

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:A genome-wide association study (GWAS) is the foremost strategy used for finding genes that control human diseases and agriculturally important traits, but it often reports false positives. In contrast, its complementary method, linkage analysis, provides direct genetic confirmation, but with limited resolut...

journal_title：BMC biology

authors： Li C,Li Y,Bradbury PJ,Wu X,Shi Y,Song Y,Zhang D,Rodgers-Melnick E,Buckler ES,Zhang Z,Li Y,Wang T

更新日期：2015-09-21 00:00:00

abstract：:Huntington's disease (HD) is one of the most common tandem repeat disorders and presents as a unique trilogy of cognitive, psychiatric and motor symptoms. One of the major mysteries of HD is why it selectively affects specific neuronal populations. A new article in BMC Biology provides a piece in the puzzle of pathoge...

journal_title：BMC biology

authors： Hannan AJ

更新日期：2018-06-27 00:00:00

abstract：BACKGROUND:Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show d...

journal_title：BMC biology

authors： Frank SA

更新日期：2004-07-08 00:00:00

abstract：BACKGROUND:ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen identified protein kinase C delta (PKCδ) as a potential ARTD10 substrate, amo...

journal_title：BMC biology

authors： Tian Y,Korn P,Tripathi P,Komnig D,Wiemuth D,Nikouee A,Classen A,Bolm C,Falkenburger BH,Lüscher B,Gründer S

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：:The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the 'micro-circuitry' of this highly organized midbrain structure filters visual input, which arrives in the supe...

journal_title：BMC biology

authors： Nevin LM,Robles E,Baier H,Scott EK

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a drivi...

journal_title：BMC biology

authors： North AR,Burt A,Godfray HCJ

更新日期：2019-03-29 00:00:00

abstract：BACKGROUND:Collective neural crest cell migration is critical to the form and function of the vertebrate face and neck, distributing bone, cartilage, and nerve cells into peripheral targets that are intimately linked with head vasculature. The vasculature and neural crest structures are ultimately linked, but when and ...

journal_title：BMC biology

authors： McKinney MC,McLennan R,Kulesa PM

更新日期：2016-12-15 00:00:00

abstract：:The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or ch...

journal_title：BMC biology

authors： Nakayama T,Archibald JM

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:Although a variety of animals have been used to produce polyclonal antibodies against antigens, the production of antigen-specific monoclonal antibodies from animals remains challenging. RESULTS:We propose a simple and rapid strategy to produce monoclonal antibodies from a variety of animals. By staining ly...

journal_title：BMC biology

authors： Kurosawa N,Yoshioka M,Fujimoto R,Yamagishi F,Isobe M

更新日期：2012-09-28 00:00:00

abstract：:In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...

journal_title：BMC biology

authors： Bell G

更新日期：2016-06-23 00:00:00

abstract：BACKGROUND:The International Mouse Phenotyping Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene-phenotype associations. While CRISPR/Cas9-mediated null allele production in mice is highly efficient, generation of conditional alleles has...

journal_title：BMC biology

authors： Lanza DG,Gaspero A,Lorenzo I,Liao L,Zheng P,Wang Y,Deng Y,Cheng C,Zhang C,Seavitt JR,DeMayo FJ,Xu J,Dickinson ME,Beaudet AL,Heaney JD

更新日期：2018-06-21 00:00:00

abstract：BACKGROUND:Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes. Inactivating single oncogenes, such as c-Myc, can reverse even advanced tumours. Intrigui...

journal_title：BMC biology

authors： Pelengaris S,Abouna S,Cheung L,Ifandi V,Zervou S,Khan M

更新日期：2004-12-21 00:00:00

abstract：BACKGROUND:Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis of aquatic primary production; most taxa are free-living, while some can form symbiotic and parasiti...

journal_title：BMC biology

authors： Stephens TG,González-Pech RA,Cheng Y,Mohamed AR,Burt DW,Bhattacharya D,Ragan MA,Chan CX

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...

journal_title：BMC biology

authors： Sunagar K,Columbus-Shenkar YY,Fridrich A,Gutkovich N,Aharoni R,Moran Y

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd gen...

journal_title：BMC biology

authors： Ignesti M,Barraco M,Nallamothu G,Woolworth JA,Duchi S,Gargiulo G,Cavaliere V,Hsu T

更新日期：2014-02-14 00:00:00

abstract：BACKGROUND:Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system. RESULTS:Adult Spragu...

journal_title：BMC biology

authors： Borlongan CV,Hayashi T,Oeltgen PR,Su TP,Wang Y

更新日期：2009-06-17 00:00:00

abstract：BACKGROUND:Microarray analysis and 454 cDNA sequencing were used to investigate a centuries-old problem in regenerative biology: the basis of nerve-dependent limb regeneration in salamanders. Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14...

journal_title：BMC biology

authors： Monaghan JR,Epp LG,Putta S,Page RB,Walker JA,Beachy CK,Zhu W,Pao GM,Verma IM,Hunter T,Bryant SV,Gardiner DM,Harkins TT,Voss SR

更新日期：2009-01-13 00:00:00

abstract：:Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core molecular elements of the ethylene-signaling pathway have been uncovered, re...

journal_title：BMC biology

authors： Chang C

更新日期：2016-01-27 00:00:00

abstract：:The five most pervasive anthropogenic threats to biodiversity are over-exploitation, habitat changes, climate change, invasive species, and pollution. Since all of these threats can affect intraspecific biodiversity-including genetic variation within populations-humans have the potential to induce contemporary microev...

journal_title：BMC biology

authors： Pelletier F,Coltman DW

更新日期：2018-01-15 00:00:00

abstract：:Malaria is a common and life-threatening disease endemic in large parts of the world. The emergence of antimalarial drug resistance is threatening disease-control measures that depend heavily on treatment of clinical malaria. The intracellular malaria parasite is particularly vulnerable during its brief extracellular ...

journal_title：BMC biology

authors： Muralidharan V,Striepen B

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:The availability of abundant sequence data from key model organisms has made large scale studies of molecular evolution an exciting possibility. Here we use full length cDNA alignments comprising more than 700,000 nucleotides from human, mouse, pig and the Japanese pufferfish Fugu rubrices in order to invest...

journal_title：BMC biology

authors： Jørgensen FG,Hobolth A,Hornshøj H,Bendixen C,Fredholm M,Schierup MH

更新日期：2005-01-28 00:00:00

abstract：:The vertebrate nervous system is deeply divided into 'somatic' and 'visceral' subsystems that respond to external and internal stimuli, respectively. Molecular characterization of neurons in different groups of mollusks by Nomaksteinsky and colleagues, published in this issue of BMC Biology, reveals that the viscero-s...

journal_title：BMC biology

authors： Bertucci P,Arendt D

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic te...

journal_title：BMC biology

authors： Fuchs S,Bundy JG,Davies SK,Viney JM,Swire JS,Leroi AM

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:Nucleostemin is a nucleolus residing GTPase that is considered to be an important cancer stem/progenitor cell marker protein due to its high expression levels in breast cancer stem cells and its role in tumor-initiation of human mammary tumor cells. It has been proposed that nucleostemin may represent a valu...

journal_title：BMC biology

authors： Tin AS,Park AH,Sundar SN,Firestone GL

更新日期：2014-09-12 00:00:00

abstract：BACKGROUND:Cellular functions can be regulated by cell-cell interactions that are influenced by extra-cellular, density-dependent signaling factors. Dictyostelium grow as individual cells in nutrient-rich sources, but, as nutrients become depleted, they initiate a multi-cell developmental program that is dependent upon...

journal_title：BMC biology

authors： Meena NP,Jaiswal P,Chang FS,Brzostowski J,Kimmel AR

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identification of protein complexes by AP/MS is complicated by the potential heterogeneity of complexes in different tissues. Here, we...

journal_title：BMC biology

authors： Waaijers S,Muñoz J,Berends C,Ramalho JJ,Goerdayal SS,Low TY,Zoumaro-Djayoon AD,Hoffmann M,Koorman T,Tas RP,Harterink M,Seelk S,Kerver J,Hoogenraad CC,Bossinger O,Tursun B,van den Heuvel S,Heck AJ,Boxem M

更新日期：2016-08-09 00:00:00

abstract：:Current interest in proteasome inhibitors for cancer therapy has stimulated considerable research efforts to identify the molecular pathway to their cytotoxicity with a view to identifying the mechanisms of sensitivity and resistance as well as informing the development of new drugs. Zhao and Vuori describe this month...

journal_title：BMC biology

authors： Chauhan D,Anderson KC

更新日期：2011-10-28 00:00:00