mTORC1/AMPK responses define a core gene set for developmental cell fate switching.

abstract：:Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous e...

journal_title：BMC biology

authors： Nussinov R,Ma B

更新日期：2012-01-25 00:00:00

abstract：BACKGROUND:Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain is also elicited by natural rewards and incentive cues, raising the possibility that some CRF systems in the brain mediate an independent function of positiv...

journal_title：BMC biology

authors： Peciña S,Schulkin J,Berridge KC

更新日期：2006-04-13 00:00:00

abstract：BACKGROUND:The red algae (Rhodophyta) diverged from the green algae and plants (Viridiplantae) over one billion years ago within the kingdom Archaeplastida. These photosynthetic lineages provide an ideal model to study plastid genome reduction in deep time. To this end, we assembled a large dataset of the plastid genom...

journal_title：BMC biology

authors： Lee J,Cho CH,Park SI,Choi JW,Song HS,West JA,Bhattacharya D,Yoon HS

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:Accurate determination of mouse positions from video data is crucial for various types of behavioral analyses. While detection of body positions is straightforward, the correct identification of nose positions, usually more informative, is far more challenging. The difficulty is largely due to variability in...

journal_title：BMC biology

authors： Ben-Shaul Y

更新日期：2017-05-15 00:00:00

abstract：:Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...

journal_title：BMC biology

authors： Keller A

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Archaeological studies have revealed a series of cultural changes around the Last Glacial Maximum in East Asia; whether these changes left any signatures in the gene pool of East Asians remains poorly indicated. To achieve deeper insights into the demographic history of modern humans in East Asia around the ...

journal_title：BMC biology

authors： Peng MS,Palanichamy MG,Yao YG,Mitra B,Cheng YT,Zhao M,Liu J,Wang HW,Pan H,Wang WZ,Zhang AM,Zhang W,Wang D,Zou Y,Yang Y,Chaudhuri TK,Kong QP,Zhang YP

更新日期：2011-01-10 00:00:00

abstract：BACKGROUND:Gene duplication provides opportunities for lineage diversification and evolution of developmental novelties. Duplicated genes generally either disappear by accumulation of mutations (nonfunctionalization), or are preserved either by the origin of positively selected functions in one or both duplicates (neof...

journal_title：BMC biology

authors： Bassham S,Cañestro C,Postlethwait JH

更新日期：2008-08-22 00:00:00

abstract：BACKGROUND:Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identification of protein complexes by AP/MS is complicated by the potential heterogeneity of complexes in different tissues. Here, we...

journal_title：BMC biology

authors： Waaijers S,Muñoz J,Berends C,Ramalho JJ,Goerdayal SS,Low TY,Zoumaro-Djayoon AD,Hoffmann M,Koorman T,Tas RP,Harterink M,Seelk S,Kerver J,Hoogenraad CC,Bossinger O,Tursun B,van den Heuvel S,Heck AJ,Boxem M

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investi...

journal_title：BMC biology

authors： Okajima T,Reddy B,Matsuda T,Irvine KD

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents. METHODS:Here, we translated the EPM to humans using mixed reality through a co...

journal_title：BMC biology

authors： Biedermann SV,Biedermann DG,Wenzlaff F,Kurjak T,Nouri S,Auer MK,Wiedemann K,Briken P,Haaker J,Lonsdorf TB,Fuss J

更新日期：2017-12-21 00:00:00

abstract：BACKGROUND:Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system. RESULTS:Adult Spragu...

journal_title：BMC biology

authors： Borlongan CV,Hayashi T,Oeltgen PR,Su TP,Wang Y

更新日期：2009-06-17 00:00:00

abstract：BACKGROUND:Sexual reproduction entails the encounter of the sexes and the multiplicity of rituals is parallel to the diversity of mating systems. Evolutionary mechanisms such as sexual selection and sexual conflict have led to the elaboration of traits to gain attention and favours from potential partners. A paradox ex...

journal_title：BMC biology

authors： Lassance JM,Löfstedt C

更新日期：2009-03-03 00:00:00

abstract：BACKGROUND:Although a variety of animals have been used to produce polyclonal antibodies against antigens, the production of antigen-specific monoclonal antibodies from animals remains challenging. RESULTS:We propose a simple and rapid strategy to produce monoclonal antibodies from a variety of animals. By staining ly...

journal_title：BMC biology

authors： Kurosawa N,Yoshioka M,Fujimoto R,Yamagishi F,Isobe M

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:Male sexually selected vocalisations generally contain both individuality and quality cues that are crucial in intra- as well as inter-sexual communication. As individuality is a fixed feature whereas male phenotypic quality changes with age, individuality and quality cues may be subjected to different selec...

journal_title：BMC biology

authors： Briefer E,Vannoni E,McElligott AG

更新日期：2010-04-09 00:00:00

abstract：:Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection. Here, we explore the roles of mitochondrial autophagy (mitophag...

journal_title：BMC biology

authors： Pellegrino MW,Haynes CM

更新日期：2015-04-03 00:00:00

abstract：BACKGROUND:The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potential confounder of these sequence-based approaches is the presence of contamination in DNA extraction ...

journal_title：BMC biology

authors： Salter SJ,Cox MJ,Turek EM,Calus ST,Cookson WO,Moffatt MF,Turner P,Parkhill J,Loman NJ,Walker AW

更新日期：2014-11-12 00:00:00

abstract：BACKGROUND:Nucleolar rDNA is tightly associated with silent heterochromatin, which is important for rDNA stability, nucleolar integration, and cellular senescence. Two pathways have been described that lead to rDNA silencing in yeast: 1) the RENT (regulator of nucleolar silencing and telophase exit) complex, which is c...

journal_title：BMC biology

authors： Ryu HY,Ahn S

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on grafting-resistant North American Vitis species as rootstocks, thereby limiting genetic stocks to...

journal_title：BMC biology

authors： Rispe C,Legeai F,Nabity PD,Fernández R,Arora AK,Baa-Puyoulet P,Banfill CR,Bao L,Barberà M,Bouallègue M,Bretaudeau A,Brisson JA,Calevro F,Capy P,Catrice O,Chertemps T,Couture C,Delière L,Douglas AE,Dufault-Thompson K

更新日期：2020-07-23 00:00:00

abstract：:The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiqu...

journal_title：BMC biology

authors： Sannino S,Brodsky JL

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:Early developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highly derived life cycles involving indirect development, and even the true orientation of the tapeworm antero-posterior (AP) axis...

journal_title：BMC biology

authors： Koziol U,Jarero F,Olson PD,Brehm K

更新日期：2016-03-04 00:00:00

abstract：:Joel Dacks is an Associate Professor and Canada Research Chair in Evolutionary Cell Biology at the University of Alberta, a Scientific Associate at the Natural History Museum (London), and the current President of the International Society for Evolutionary Protistology. His research group studies the evolution and div...

journal_title：BMC biology

authors： Dacks JB

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The pituitary gland is formed by the juxtaposition of two tissues: neuroectoderm arising from the basal diencephalon, and oral epithelium, which invaginates towards the central nervous system from the roof of the mouth. The oral invagination that reaches the brain from the mouth is referred to as Rathke's po...

journal_title：BMC biology

authors： Khonsari RH,Seppala M,Pradel A,Dutel H,Clément G,Lebedev O,Ghafoor S,Rothova M,Tucker A,Maisey JG,Fan CM,Kawasaki M,Ohazama A,Tafforeau P,Franco B,Helms J,Haycraft CJ,David A,Janvier P,Cobourne MT,Sharpe PT

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:Microarray analysis and 454 cDNA sequencing were used to investigate a centuries-old problem in regenerative biology: the basis of nerve-dependent limb regeneration in salamanders. Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14...

journal_title：BMC biology

authors： Monaghan JR,Epp LG,Putta S,Page RB,Walker JA,Beachy CK,Zhu W,Pao GM,Verma IM,Hunter T,Bryant SV,Gardiner DM,Harkins TT,Voss SR

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:Insects helped pioneer, and persist as model organisms for, the study of specific aspects of immunity. Although they lack an adaptive immune system, insects possess an innate immune system that recognizes and destroys intruding microorganisms. Its operation under natural conditions has not been well studied,...

journal_title：BMC biology

authors： Freitak D,Wheat CW,Heckel DG,Vogel H

更新日期：2007-12-21 00:00:00

abstract：:In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...

journal_title：BMC biology

authors： Bell G

更新日期：2016-06-23 00:00:00

abstract：BACKGROUND:Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identities have been assigned to all neurons, the number of annotatable neurons in an intact animal has...

journal_title：BMC biology

authors： Toyoshima Y,Wu S,Kanamori M,Sato H,Jang MS,Oe S,Murakami Y,Teramoto T,Park C,Iwasaki Y,Ishihara T,Yoshida R,Iino Y

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as reservoirs of resistance genes for human pathogens. Anthropogenic activity may contribute to the sp...

journal_title：BMC biology

authors： Marcelino VR,Wille M,Hurt AC,González-Acuña D,Klaassen M,Schlub TE,Eden JS,Shi M,Iredell JR,Sorrell TC,Holmes EC

更新日期：2019-04-08 00:00:00

abstract：:Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core molecular elements of the ethylene-signaling pathway have been uncovered, re...

journal_title：BMC biology

authors： Chang C

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracti...

journal_title：BMC biology

authors： van Kessel SP,de Jong HR,Winkel SL,van Leeuwen SS,Nelemans SA,Permentier H,Keshavarzian A,El Aidy S

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of standardized a...

journal_title：BMC biology

authors： Hundeshagen P,Hamacher-Brady A,Eils R,Brady NR

更新日期：2011-06-02 00:00:00