Synaptopathy, circuitopathy and the computational biology of Huntington's disease.

abstract：BACKGROUND:The ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is intimately linked to gene regulation, much less is known about the...

journal_title：BMC biology

authors： Hui JH,Raible F,Korchagina N,Dray N,Samain S,Magdelenat G,Jubin C,Segurens B,Balavoine G,Arendt D,Ferrier DE

更新日期：2009-07-23 00:00:00

abstract：BACKGROUND:Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins. RESULTS:Here we mined the human proteome and identified the membrane proteome subset using three prediction tools for alpha-hel...

journal_title：BMC biology

authors： Almén MS,Nordström KJ,Fredriksson R,Schiöth HB

更新日期：2009-08-13 00:00:00

abstract：:Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic...

journal_title：BMC biology

authors： Rappuoli R

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Eukaryotic genome assembly remains a challenge in part due to the prevalence of complex DNA repeats. This is a particularly acute problem for holocentric nematodes because of the large number of satellite DNA sequences found throughout their genomes. These have been recalcitrant to most genome sequencing met...

journal_title：BMC biology

authors： Eccles D,Chandler J,Camberis M,Henrissat B,Koren S,Le Gros G,Ewbank JJ

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. reinhardtii, yet only two-the channelrhodopsins-were functionally characterized. Characterization of ...

journal_title：BMC biology

authors： Tian Y,Gao S,von der Heyde EL,Hallmann A,Nagel G

更新日期：2018-12-06 00:00:00

abstract：BACKGROUND:Vertebrates are characterized by possession of hypobranchial muscles (HBMs). Cyclostomes, or modern jawless vertebrates, possess a rudimentary and superficial HBM lateral to the pharynx, whereas the HBM in jawed vertebrates is internalized and anteroposteriorly specified. Precursor cells of the HBM, marked b...

journal_title：BMC biology

authors： Kusakabe R,Higuchi S,Tanaka M,Kadota M,Nishimura O,Kuratani S

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...

journal_title：BMC biology

authors： Beckmann A,Xiao S,Müller JP,Mercadante D,Nüchter T,Kröger N,Langhojer F,Petrich W,Holstein TW,Benoit M,Gräter F,Özbek S

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identities have been assigned to all neurons, the number of annotatable neurons in an intact animal has...

journal_title：BMC biology

authors： Toyoshima Y,Wu S,Kanamori M,Sato H,Jang MS,Oe S,Murakami Y,Teramoto T,Park C,Iwasaki Y,Ishihara T,Yoshida R,Iino Y

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show d...

journal_title：BMC biology

authors： Frank SA

更新日期：2004-07-08 00:00:00

abstract：:There are many reasons to be interested in stem cells, one of the most prominent being their potential use in finding better drugs to treat human disease. This article focuses on how this may be implemented. Recent advances in the production of reprogrammed adult cells and their regulated differentiation to disease-re...

journal_title：BMC biology

authors： Rubin LL,Haston KM

更新日期：2011-06-07 00:00:00

abstract：BACKGROUND:How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. RESULTS:By exploring the possible effects of v...

journal_title：BMC biology

authors： Buzi G,Lander AD,Khammash M

更新日期：2015-02-19 00:00:00

abstract：BACKGROUND:Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species a...

journal_title：BMC biology

authors： Päivinen J,Grapputo A,Kaitala V,Komonen A,Kotiaho JS,Saarinen K,Wahlberg N

更新日期：2005-03-01 00:00:00

abstract：:In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...

journal_title：BMC biology

authors： Bell G

更新日期：2016-06-23 00:00:00

abstract：BACKGROUND:Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic te...

journal_title：BMC biology

authors： Fuchs S,Bundy JG,Davies SK,Viney JM,Swire JS,Leroi AM

更新日期：2010-02-10 00:00:00

abstract：:The elevated metabolic requirements of cancer cells reflect their rapid growth and proliferation and are met through mutations in oncogenes and tumor suppressor genes that reprogram cellular processes. For example, in tuberous sclerosis complex (TSC)-related tumors, the loss of TSC1/2 function causes constitutive mTOR...

journal_title：BMC biology

authors： Csibi A,Blenis J

更新日期：2011-10-21 00:00:00

abstract：BACKGROUND:Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion...

journal_title：BMC biology

authors： Qin W,Lu X,Liu Y,Bai H,Li S,Lin S

更新日期：2018-11-20 00:00:00

abstract：:The vertebrate nervous system is deeply divided into 'somatic' and 'visceral' subsystems that respond to external and internal stimuli, respectively. Molecular characterization of neurons in different groups of mollusks by Nomaksteinsky and colleagues, published in this issue of BMC Biology, reveals that the viscero-s...

journal_title：BMC biology

authors： Bertucci P,Arendt D

更新日期：2013-04-30 00:00:00

abstract：:The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology, demonstrate through phylogenetic analysis of the CCA1/LHY and TOC1/PRR gene families that the common ancestor of monocots and eudicots had compone...

journal_title：BMC biology

authors： McClung CR

更新日期：2010-05-07 00:00:00

abstract：BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...

journal_title：BMC biology

authors： Cary GA,Wolff A,Zueva O,Pattinato J,Hinman VF

更新日期：2019-02-22 00:00:00

abstract：:The five most pervasive anthropogenic threats to biodiversity are over-exploitation, habitat changes, climate change, invasive species, and pollution. Since all of these threats can affect intraspecific biodiversity-including genetic variation within populations-humans have the potential to induce contemporary microev...

journal_title：BMC biology

authors： Pelletier F,Coltman DW

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission. Here, we evaluate the impact of fo...

journal_title：BMC biology

authors： Zhu M,Cortese GP,Waites CL

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...

journal_title：BMC biology

authors： Huminiecki L,Heldin CH

更新日期：2010-12-13 00:00:00

abstract：BACKGROUND:Seed plants are composed of angiosperms and gymnosperms, which diverged from each other around 300 million years ago. While much light has been shed on the mechanisms and rate of genome evolution in flowering plants, such knowledge remains conspicuously meagre for the gymnosperms. Conifers are key representa...

journal_title：BMC biology

authors： Pavy N,Pelgas B,Laroche J,Rigault P,Isabel N,Bousquet J

更新日期：2012-10-26 00:00:00

abstract：BACKGROUND:Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (AC...

journal_title：BMC biology

authors： Kloehn J,Oppenheim RD,Siddiqui G,De Bock PJ,Kumar Dogga S,Coute Y,Hakimi MA,Creek DJ,Soldati-Favre D

更新日期：2020-06-16 00:00:00

abstract：:The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in mediating these responses. See research article http://www.biomedcentra...

journal_title：BMC biology

authors： Whitmarsh AJ

更新日期：2010-04-27 00:00:00

abstract：BACKGROUND:The International Mouse Phenotyping Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene-phenotype associations. While CRISPR/Cas9-mediated null allele production in mice is highly efficient, generation of conditional alleles has...

journal_title：BMC biology

authors： Lanza DG,Gaspero A,Lorenzo I,Liao L,Zheng P,Wang Y,Deng Y,Cheng C,Zhang C,Seavitt JR,DeMayo FJ,Xu J,Dickinson ME,Beaudet AL,Heaney JD

更新日期：2018-06-21 00:00:00

abstract：BACKGROUND:Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enormously to the subsistence and socio-cultural lives of millions of people, principally in West and ...

journal_title：BMC biology

authors： Tamiru M,Natsume S,Takagi H,White B,Yaegashi H,Shimizu M,Yoshida K,Uemura A,Oikawa K,Abe A,Urasaki N,Matsumura H,Babil P,Yamanaka S,Matsumoto R,Muranaka S,Girma G,Lopez-Montes A,Gedil M,Bhattacharjee R,Abberton M

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial respiratory chain (MRC). The mechanisms of the latter effects are unclear. The aim of this study was to determine the mechanisms by wh...

journal_title：BMC biology

authors： García-Ruiz I,Solís-Muñoz P,Fernández-Moreira D,Muñoz-Yagüe T,Solís-Herruzo JA

更新日期：2013-08-01 00:00:00

abstract：:Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent paper in BMC Systems Biology describes a promising step in this direction. ...

journal_title：BMC biology

authors： Przytycka TM,Kim YA

更新日期：2010-04-28 00:00:00