Teaching old drugs new tricks to stop malaria invasion in its tracks.

abstract：BACKGROUND:Annotation of cell identity is an essential process in neuroscience that allows comparison of cells, including that of neural activities across different animals. In Caenorhabditis elegans, although unique identities have been assigned to all neurons, the number of annotatable neurons in an intact animal has...

journal_title：BMC biology

authors： Toyoshima Y,Wu S,Kanamori M,Sato H,Jang MS,Oe S,Murakami Y,Teramoto T,Park C,Iwasaki Y,Ishihara T,Yoshida R,Iino Y

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is not reversible. A number of methods have been developed to overcome this, but each method has its own limitations. RESULTS:We d...

journal_title：BMC biology

authors： Chaiyachati BH,Kaundal RK,Zhao J,Wu J,Flavell R,Chi T

更新日期：2012-11-30 00:00:00

abstract：BACKGROUND:Marine molluscs, as is the case with most aquatic animals, rely heavily on olfactory cues for survival. In the mollusc Aplysia californica, mate-attraction is mediated by a blend of water-borne protein pheromones that are detected by sensory structures called rhinophores. The expression of G protein and phos...

journal_title：BMC biology

authors： Cummins SF,Erpenbeck D,Zou Z,Claudianos C,Moroz LL,Nagle GT,Degnan BM

更新日期：2009-06-04 00:00:00

abstract：BACKGROUND:Gene duplication provides opportunities for lineage diversification and evolution of developmental novelties. Duplicated genes generally either disappear by accumulation of mutations (nonfunctionalization), or are preserved either by the origin of positively selected functions in one or both duplicates (neof...

journal_title：BMC biology

authors： Bassham S,Cañestro C,Postlethwait JH

更新日期：2008-08-22 00:00:00

abstract：:A recent paper in BMC Structural Biology reports the crystal structure of human prolylcarboxypeptidase (PRCP), one of the two members of the S28 peptidase family. Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic ...

journal_title：BMC biology

authors： Kozarich JW

更新日期：2010-06-28 00:00:00

abstract：BACKGROUND:Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the polyploid nature, high genome complexity and lack of genomic sequence integration with reproductive tiss...

journal_title：BMC biology

authors： Rabiger DS,Taylor JM,Spriggs A,Hand ML,Henderson ST,Johnson SD,Oelkers K,Hrmova M,Saito K,Suzuki G,Mukai Y,Carroll BJ,Koltunow AM

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...

journal_title：BMC biology

authors： Ely B,Wilson JL,Jackson F,Jackson BA

更新日期：2006-10-12 00:00:00

abstract：BACKGROUND:A genome-wide association study (GWAS) is the foremost strategy used for finding genes that control human diseases and agriculturally important traits, but it often reports false positives. In contrast, its complementary method, linkage analysis, provides direct genetic confirmation, but with limited resolut...

journal_title：BMC biology

authors： Li C,Li Y,Bradbury PJ,Wu X,Shi Y,Song Y,Zhang D,Rodgers-Melnick E,Buckler ES,Zhang Z,Li Y,Wang T

更新日期：2015-09-21 00:00:00

abstract：:Animal domestication has fascinated biologists since Charles Darwin first drew the parallel between evolution via natural selection and human-mediated breeding of livestock and companion animals. In this review we show how studies of ancient DNA from domestic animals and their wild progenitors and congeners have shed ...

journal_title：BMC biology

authors： McHugo GP,Dover MJ,MacHugh DE

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:The ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is intimately linked to gene regulation, much less is known about the...

journal_title：BMC biology

authors： Hui JH,Raible F,Korchagina N,Dray N,Samain S,Magdelenat G,Jubin C,Segurens B,Balavoine G,Arendt D,Ferrier DE

更新日期：2009-07-23 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：:Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell-cell communication and the transmission of disease states, and explored as a means of drug discovery. Yet fundamental questions about their biology remain unanswered. Here I explore what exosomes are, highlight the di...

journal_title：BMC biology

authors： Edgar JR

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal muscles of patients ...

journal_title：BMC biology

authors： Strah N,Romano G,Introna C,Klima R,Marzullo M,Ciapponi L,Megighian A,Nizzardo M,Feiguin F

更新日期：2020-03-26 00:00:00

abstract：:The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the 'micro-circuitry' of this highly organized midbrain structure filters visual input, which arrives in the supe...

journal_title：BMC biology

authors： Nevin LM,Robles E,Baier H,Scott EK

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:The availability of abundant sequence data from key model organisms has made large scale studies of molecular evolution an exciting possibility. Here we use full length cDNA alignments comprising more than 700,000 nucleotides from human, mouse, pig and the Japanese pufferfish Fugu rubrices in order to invest...

journal_title：BMC biology

authors： Jørgensen FG,Hobolth A,Hornshøj H,Bendixen C,Fredholm M,Schierup MH

更新日期：2005-01-28 00:00:00

abstract：BACKGROUND:Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)- or homology-directed repair-m...

journal_title：BMC biology

authors： Alexander J,Findlay GM,Kircher M,Shendure J

更新日期：2019-11-18 00:00:00

abstract：BACKGROUND:ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III filam...

journal_title：BMC biology

authors： Harker-Kirschneck L,Baum B,Šarić AE

更新日期：2019-10-22 00:00:00

abstract：:Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic...

journal_title：BMC biology

authors： Rappuoli R

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...

journal_title：BMC biology

authors： Zeng J,Howard JC

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple categories of ncRNAs and characterization of the way their expression is regulated. We previously sho...

journal_title：BMC biology

authors： Cherlin T,Magee R,Jing Y,Pliatsika V,Loher P,Rigoutsos I

更新日期：2020-04-13 00:00:00

abstract：:Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcriptio...

journal_title：BMC biology

authors： Koonin EV,Krupovic M,Ishino S,Ishino Y

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...

journal_title：BMC biology

authors： Le Roy T,Lécuyer E,Chassaing B,Rhimi M,Lhomme M,Boudebbouze S,Ichou F,Haro Barceló J,Huby T,Guerin M,Giral P,Maguin E,Kapel N,Gérard P,Clément K,Lesnik P

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:The processes by which eggs develop in the insect ovary are well characterized. Despite a large number of Drosophila mutants that cannot lay eggs, the way that the egg is moved along the reproductive tract from ovary to uterus is less well understood. We remedy this with an integrative study on the reproduct...

journal_title：BMC biology

authors： Middleton CA,Nongthomba U,Parry K,Sweeney ST,Sparrow JC,Elliott CJ

更新日期：2006-06-12 00:00:00

abstract：:Few would argue that science is better done in silos, with no transparency or sharing of methods and resources. Yet scientists and scientific stakeholders (e.g., academic institutions, funding agencies, journals) alike continue to find themselves at a relative impasse in the implementation of open science practices, s...

journal_title：BMC biology

authors： Milham MP,Klein A

更新日期：2019-03-27 00:00:00

abstract：BACKGROUND:Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living cells. Recently, fluorescence resonance energy transfer (FRET) sensors...

journal_title：BMC biology

authors： Adjobo-Hermans MJ,Goedhart J,van Weeren L,Nijmeijer S,Manders EM,Offermanns S,Gadella TW Jr

更新日期：2011-05-27 00:00:00

abstract：BACKGROUND:Male sexually selected vocalisations generally contain both individuality and quality cues that are crucial in intra- as well as inter-sexual communication. As individuality is a fixed feature whereas male phenotypic quality changes with age, individuality and quality cues may be subjected to different selec...

journal_title：BMC biology

authors： Briefer E,Vannoni E,McElligott AG

更新日期：2010-04-09 00:00:00

abstract：:The elevated metabolic requirements of cancer cells reflect their rapid growth and proliferation and are met through mutations in oncogenes and tumor suppressor genes that reprogram cellular processes. For example, in tuberous sclerosis complex (TSC)-related tumors, the loss of TSC1/2 function causes constitutive mTOR...

journal_title：BMC biology

authors： Csibi A,Blenis J

更新日期：2011-10-21 00:00:00

abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...

journal_title：BMC biology

authors： Huminiecki L,Heldin CH

更新日期：2010-12-13 00:00:00

abstract：BACKGROUND:Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all...

journal_title：BMC biology

authors： Volkers RJ,Snoek LB,Hubar CJ,Coopman R,Chen W,Yang W,Sterken MG,Schulenburg H,Braeckman BP,Kammenga JE

更新日期：2013-08-19 00:00:00

abstract：BACKGROUND:For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been proposed on their basis. However, the difficulty in investigating complex I semiquinones, due to the...

journal_title：BMC biology

authors： Wright JJ,Fedor JG,Hirst J,Roessler MM

更新日期：2020-05-20 00:00:00