Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors.

abstract：:The five most pervasive anthropogenic threats to biodiversity are over-exploitation, habitat changes, climate change, invasive species, and pollution. Since all of these threats can affect intraspecific biodiversity-including genetic variation within populations-humans have the potential to induce contemporary microev...

journal_title：BMC biology

authors： Pelletier F,Coltman DW

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion...

journal_title：BMC biology

authors： Qin W,Lu X,Liu Y,Bai H,Li S,Lin S

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Accurate determination of mouse positions from video data is crucial for various types of behavioral analyses. While detection of body positions is straightforward, the correct identification of nose positions, usually more informative, is far more challenging. The difficulty is largely due to variability in...

journal_title：BMC biology

authors： Ben-Shaul Y

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：BACKGROUND:Effective disease management depends on timely and accurate diagnosis to guide control measures. The capacity to distinguish between individuals in a pathogen population with specific properties such as fungicide resistance, toxin production and virulence profiles is often essential to inform disease managem...

journal_title：BMC biology

authors： Radhakrishnan GV,Cook NM,Bueno-Sancho V,Lewis CM,Persoons A,Mitiku AD,Heaton M,Davey PE,Abeyo B,Alemayehu Y,Badebo A,Barnett M,Bryant R,Chatelain J,Chen X,Dong S,Henriksson T,Holdgate S,Justesen AF,Kalous J,Kang Z

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...

journal_title：BMC biology

authors： Huminiecki L,Heldin CH

更新日期：2010-12-13 00:00:00

abstract：BACKGROUND:Sec8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function, including neurite outgrowth, calcium-dependent neurotransmitter secretion, trafficking of ionotropic glutamate receptors and regulation of neuronal microtubule ass...

journal_title：BMC biology

authors： Liebl FL,Chen K,Karr J,Sheng Q,Featherstone DE

更新日期：2005-12-13 00:00:00

abstract：BACKGROUND:The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant ...

journal_title：BMC biology

authors： Boursereau R,Abou-Samra M,Lecompte S,Noel L,Brichard SM

更新日期：2018-03-20 00:00:00

abstract：:In the ubiquitin-proteasome system, a subset of ubiquitylated proteins requires the AAA+ ATPase p97 (also known as VCP or Cdc48) for extraction from membranes or protein complexes before delivery to the proteasome for degradation. Diverse ubiquitin adapters are known to link p97 to its client proteins, but two recent ...

journal_title：BMC biology

authors： Meyer H

更新日期：2012-06-13 00:00:00

abstract：BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...

journal_title：BMC biology

authors： Cary GA,Wolff A,Zueva O,Pattinato J,Hinman VF

更新日期：2019-02-22 00:00:00

abstract：:Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcriptio...

journal_title：BMC biology

authors： Koonin EV,Krupovic M,Ishino S,Ishino Y

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple categories of ncRNAs and characterization of the way their expression is regulated. We previously sho...

journal_title：BMC biology

authors： Cherlin T,Magee R,Jing Y,Pliatsika V,Loher P,Rigoutsos I

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Collective neural crest cell migration is critical to the form and function of the vertebrate face and neck, distributing bone, cartilage, and nerve cells into peripheral targets that are intimately linked with head vasculature. The vasculature and neural crest structures are ultimately linked, but when and ...

journal_title：BMC biology

authors： McKinney MC,McLennan R,Kulesa PM

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show d...

journal_title：BMC biology

authors： Frank SA

更新日期：2004-07-08 00:00:00

abstract：BACKGROUND:TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors. RES...

journal_title：BMC biology

authors： Lammirato A,Patsch K,Feiereisen F,Maly K,Nofziger C,Paulmichl M,Hackl H,Trajanoski Z,Valovka T,Huber LA,Vietor I

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. reinhardtii, yet only two-the channelrhodopsins-were functionally characterized. Characterization of ...

journal_title：BMC biology

authors： Tian Y,Gao S,von der Heyde EL,Hallmann A,Nagel G

更新日期：2018-12-06 00:00:00

abstract：:The expansion of genome sequencing projects has produced accumulating evidence for lateral transfer of genes between prokaryotic and eukaryotic genomes. However, it remains controversial whether these genes are of functional importance in their recipient host. Nikoh and Nakabachi, in a recent paper in BMC Biology, tak...

journal_title：BMC biology

authors： Ros VI,Hurst GD

更新日期：2009-05-05 00:00:00

abstract：BACKGROUND:O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investi...

journal_title：BMC biology

authors： Okajima T,Reddy B,Matsuda T,Irvine KD

更新日期：2008-01-14 00:00:00

abstract：:Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...

journal_title：BMC biology

authors： Keller A

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development. Conversely, trithorax-group (trxG) genes encode positive factors required for maintenance of long term Hox gene activation. Both kinds of factors bind chromatin regions called maintenance elements ...

journal_title：BMC biology

authors： Salvaing J,Decoville M,Mouchel-Vielh E,Bussière M,Daulny A,Boldyreva L,Zhimulev I,Locker D,Peronnet F

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis of aquatic primary production; most taxa are free-living, while some can form symbiotic and parasiti...

journal_title：BMC biology

authors： Stephens TG,González-Pech RA,Cheng Y,Mohamed AR,Burt DW,Bhattacharya D,Ragan MA,Chan CX

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not been carried out. RESULTS:Through an RNA interference screen, and using a prosta...

journal_title：BMC biology

authors： Tajadura-Ortega V,Garg R,Allen R,Owczarek C,Bright MD,Kean S,Mohd-Noor A,Grigoriadis A,Elston TC,Hahn KM,Ridley AJ

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:Vertebrates are characterized by possession of hypobranchial muscles (HBMs). Cyclostomes, or modern jawless vertebrates, possess a rudimentary and superficial HBM lateral to the pharynx, whereas the HBM in jawed vertebrates is internalized and anteroposteriorly specified. Precursor cells of the HBM, marked b...

journal_title：BMC biology

authors： Kusakabe R,Higuchi S,Tanaka M,Kadota M,Nishimura O,Kuratani S

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enormously to the subsistence and socio-cultural lives of millions of people, principally in West and ...

journal_title：BMC biology

authors： Tamiru M,Natsume S,Takagi H,White B,Yaegashi H,Shimizu M,Yoshida K,Uemura A,Oikawa K,Abe A,Urasaki N,Matsumura H,Babil P,Yamanaka S,Matsumoto R,Muranaka S,Girma G,Lopez-Montes A,Gedil M,Bhattacharjee R,Abberton M

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:The pituitary gland is formed by the juxtaposition of two tissues: neuroectoderm arising from the basal diencephalon, and oral epithelium, which invaginates towards the central nervous system from the roof of the mouth. The oral invagination that reaches the brain from the mouth is referred to as Rathke's po...

journal_title：BMC biology

authors： Khonsari RH,Seppala M,Pradel A,Dutel H,Clément G,Lebedev O,Ghafoor S,Rothova M,Tucker A,Maisey JG,Fan CM,Kawasaki M,Ohazama A,Tafforeau P,Franco B,Helms J,Haycraft CJ,David A,Janvier P,Cobourne MT,Sharpe PT

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:The processes by which eggs develop in the insect ovary are well characterized. Despite a large number of Drosophila mutants that cannot lay eggs, the way that the egg is moved along the reproductive tract from ovary to uterus is less well understood. We remedy this with an integrative study on the reproduct...

journal_title：BMC biology

authors： Middleton CA,Nongthomba U,Parry K,Sweeney ST,Sparrow JC,Elliott CJ

更新日期：2006-06-12 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such as the relatively common neonatal hypertroph...

journal_title：BMC biology

authors： Li Y,Pan J,Wei C,Chen J,Liu Y,Liu J,Zhang X,Evans SM,Cui Y,Cui S

更新日期：2014-03-27 00:00:00

abstract：:Huntington's disease (HD) is one of the most common tandem repeat disorders and presents as a unique trilogy of cognitive, psychiatric and motor symptoms. One of the major mysteries of HD is why it selectively affects specific neuronal populations. A new article in BMC Biology provides a piece in the puzzle of pathoge...

journal_title：BMC biology

authors： Hannan AJ

更新日期：2018-06-27 00:00:00

abstract：:The majority of convincingly documented cases of hybridization in angiosperms has involved genetic introgression between the parental species or formation of a hybrid species with increased ploidy; however, homoploid (diploid) hybridization may be just as common. Recent studies, including one in BMC Evolutionary Biolo...

journal_title：BMC biology

authors： Chase MW,Paun O,Fay MF

更新日期：2010-04-21 00:00:00