Abstract:
:A recent paper in BMC Structural Biology reports the crystal structure of human prolylcarboxypeptidase (PRCP), one of the two members of the S28 peptidase family. Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine. See research article: http://www.biomedcentral.com/1472-6807/10/16/
journal_name
BMC Bioljournal_title
BMC biologyauthors
Kozarich JWdoi
10.1186/1741-7007-8-87subject
Has Abstractpub_date
2010-06-28 00:00:00pages
87issn
1741-7007pii
1741-7007-8-87journal_volume
8pub_type
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