Somatic and visceral nervous systems - an ancient duality.

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：BACKGROUND:The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. reinhardtii, yet only two-the channelrhodopsins-were functionally characterized. Characterization of ...

journal_title：BMC biology

authors： Tian Y,Gao S,von der Heyde EL,Hallmann A,Nagel G

更新日期：2018-12-06 00:00:00

abstract：BACKGROUND:Methods for assigning strains to bacterial species are cumbersome and no longer fit for purpose. The concatenated sequences of multiple house-keeping genes have been shown to be able to define and circumscribe bacterial species as sequence clusters. The advantage of this approach (multilocus sequence analysi...

journal_title：BMC biology

authors： Bishop CJ,Aanensen DM,Jordan GE,Kilian M,Hanage WP,Spratt BG

更新日期：2009-01-26 00:00:00

abstract：BACKGROUND:The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant ...

journal_title：BMC biology

authors： Boursereau R,Abou-Samra M,Lecompte S,Noel L,Brichard SM

更新日期：2018-03-20 00:00:00

abstract：:The global spread of SARS-CoV-2 has shaken our health care and economic systems, prompting re-evaluation of long-held views on how best to deliver care. This is especially the case for our global diagnostic strategy. While current laboratory-based centralized RT-qPCR will continue to serve as a gold standard diagnosti...

journal_title：BMC biology

authors： Matthews Q,da Silva SJR,Norouzi M,Pena LJ,Pardee K

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents. METHODS:Here, we translated the EPM to humans using mixed reality through a co...

journal_title：BMC biology

authors： Biedermann SV,Biedermann DG,Wenzlaff F,Kurjak T,Nouri S,Auer MK,Wiedemann K,Briken P,Haaker J,Lonsdorf TB,Fuss J

更新日期：2017-12-21 00:00:00

abstract：BACKGROUND:Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species a...

journal_title：BMC biology

authors： Päivinen J,Grapputo A,Kaitala V,Komonen A,Kotiaho JS,Saarinen K,Wahlberg N

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Sec8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function, including neurite outgrowth, calcium-dependent neurotransmitter secretion, trafficking of ionotropic glutamate receptors and regulation of neuronal microtubule ass...

journal_title：BMC biology

authors： Liebl FL,Chen K,Karr J,Sheng Q,Featherstone DE

更新日期：2005-12-13 00:00:00

abstract：BACKGROUND:Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the number of non-coding RNAs identified in various organisms. While we have mechanistic underst...

journal_title：BMC biology

authors： Akay A,Jordan D,Navarro IC,Wrzesinski T,Ponting CP,Miska EA,Haerty W

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Microarray analysis and 454 cDNA sequencing were used to investigate a centuries-old problem in regenerative biology: the basis of nerve-dependent limb regeneration in salamanders. Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14...

journal_title：BMC biology

authors： Monaghan JR,Epp LG,Putta S,Page RB,Walker JA,Beachy CK,Zhu W,Pao GM,Verma IM,Hunter T,Bryant SV,Gardiner DM,Harkins TT,Voss SR

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis of aquatic primary production; most taxa are free-living, while some can form symbiotic and parasiti...

journal_title：BMC biology

authors： Stephens TG,González-Pech RA,Cheng Y,Mohamed AR,Burt DW,Bhattacharya D,Ragan MA,Chan CX

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Male sexually selected vocalisations generally contain both individuality and quality cues that are crucial in intra- as well as inter-sexual communication. As individuality is a fixed feature whereas male phenotypic quality changes with age, individuality and quality cues may be subjected to different selec...

journal_title：BMC biology

authors： Briefer E,Vannoni E,McElligott AG

更新日期：2010-04-09 00:00:00

abstract：:Current interest in proteasome inhibitors for cancer therapy has stimulated considerable research efforts to identify the molecular pathway to their cytotoxicity with a view to identifying the mechanisms of sensitivity and resistance as well as informing the development of new drugs. Zhao and Vuori describe this month...

journal_title：BMC biology

authors： Chauhan D,Anderson KC

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:The internal organization of cells depends on mechanisms to ensure that transport carriers, such as vesicles, fuse only with the correct destination organelle. Several types of proteins have been proposed to confer specificity to this process, and we have recently shown that a set of coiled-coil proteins on ...

journal_title：BMC biology

authors： Wong M,Gillingham AK,Munro S

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III filam...

journal_title：BMC biology

authors： Harker-Kirschneck L,Baum B,Šarić AE

更新日期：2019-10-22 00:00:00

abstract：BACKGROUND:Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins. RESULTS:Here we mined the human proteome and identified the membrane proteome subset using three prediction tools for alpha-hel...

journal_title：BMC biology

authors： Almén MS,Nordström KJ,Fredriksson R,Schiöth HB

更新日期：2009-08-13 00:00:00

abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...

journal_title：BMC biology

authors： Gordon-Keylock S,Medvinsky A

更新日期：2011-12-28 00:00:00

abstract：BACKGROUND:Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development. Conversely, trithorax-group (trxG) genes encode positive factors required for maintenance of long term Hox gene activation. Both kinds of factors bind chromatin regions called maintenance elements ...

journal_title：BMC biology

authors： Salvaing J,Decoville M,Mouchel-Vielh E,Bussière M,Daulny A,Boldyreva L,Zhimulev I,Locker D,Peronnet F

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...

journal_title：BMC biology

authors： Huminiecki L,Heldin CH

更新日期：2010-12-13 00:00:00

abstract：BACKGROUND:The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest that this conversion occurs via a cholesterol-sensitive process, as chol...

journal_title：BMC biology

authors： Bate C,Tayebi M,Diomede L,Salmona M,Williams A

更新日期：2008-09-12 00:00:00

abstract：:A recent report in BMC Biology on the discovery and analysis of biosynthetic genes for ribosomal peptide natural products confirms that these pathways are much more common and diverse than previously suspected, contributing substantially to the chemical arsenal employed by bacteria. See research article http://www.bio...

journal_title：BMC biology

authors： Schmidt EW

更新日期：2010-06-17 00:00:00

abstract：BACKGROUND:Internal tagging of proteins by inserting small functional peptides into surface accessible permissive sites has proven to be an indispensable tool for basic and applied science. Permissive sites are typically identified by transposon mutagenesis on a case-by-case basis, limiting scalability and their exploi...

journal_title：BMC biology

authors： Oesterle S,Roberts TM,Widmer LA,Mustafa H,Panke S,Billerbeck S

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:Many proteins of the mitochondrial intermembrane space (IMS) contain structural disulfide bonds formed by the mitochondrial disulfide relay. In fungi and animals, the sulfhydryl oxidase Erv1 'generates' disulfide bonds that are passed on to the oxidoreductase Mia40, which oxidizes substrate proteins. A diffe...

journal_title：BMC biology

authors： Peleh V,Zannini F,Backes S,Rouhier N,Herrmann JM

更新日期：2017-11-08 00:00:00

abstract：:Cells are highly complex and orderly machines, with defined shapes and a startling variety of internal organizations. Complex geometry is a feature of both free-living unicellular organisms and cells inside multicellular animals. Where does the geometry of a cell come from? Many of the same questions that arise in dev...

journal_title：BMC biology

authors： Marshall WF

更新日期：2011-08-31 00:00:00

abstract：BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...

journal_title：BMC biology

authors： Zeng J,Howard JC

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors. RES...

journal_title：BMC biology

authors： Lammirato A,Patsch K,Feiereisen F,Maly K,Nofziger C,Paulmichl M,Hackl H,Trajanoski Z,Valovka T,Huber LA,Vietor I

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation initiation factors are also commonly found to be either amplified or mis-regulated in tumours, includ...

journal_title：BMC biology

authors： Frosi Y,Usher R,Lian DTG,Lane DP,Brown CJ

更新日期：2019-05-22 00:00:00

abstract：:The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiqu...

journal_title：BMC biology

authors： Sannino S,Brodsky JL

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple categories of ncRNAs and characterization of the way their expression is regulated. We previously sho...

journal_title：BMC biology

authors： Cherlin T,Magee R,Jing Y,Pliatsika V,Loher P,Rigoutsos I

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Early developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highly derived life cycles involving indirect development, and even the true orientation of the tapeworm antero-posterior (AP) axis...

journal_title：BMC biology

authors： Koziol U,Jarero F,Olson PD,Brehm K

更新日期：2016-03-04 00:00:00