Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates.

abstract：BACKGROUND:The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation initiation factors are also commonly found to be either amplified or mis-regulated in tumours, includ...

journal_title：BMC biology

authors： Frosi Y,Usher R,Lian DTG,Lane DP,Brown CJ

更新日期：2019-05-22 00:00:00

abstract：:In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...

journal_title：BMC biology

authors： Bell G

更新日期：2016-06-23 00:00:00

abstract：:There are many reasons to be interested in stem cells, one of the most prominent being their potential use in finding better drugs to treat human disease. This article focuses on how this may be implemented. Recent advances in the production of reprogrammed adult cells and their regulated differentiation to disease-re...

journal_title：BMC biology

authors： Rubin LL,Haston KM

更新日期：2011-06-07 00:00:00

abstract：BACKGROUND:Methods for assigning strains to bacterial species are cumbersome and no longer fit for purpose. The concatenated sequences of multiple house-keeping genes have been shown to be able to define and circumscribe bacterial species as sequence clusters. The advantage of this approach (multilocus sequence analysi...

journal_title：BMC biology

authors： Bishop CJ,Aanensen DM,Jordan GE,Kilian M,Hanage WP,Spratt BG

更新日期：2009-01-26 00:00:00

abstract：BACKGROUND:A genome-wide association study (GWAS) is the foremost strategy used for finding genes that control human diseases and agriculturally important traits, but it often reports false positives. In contrast, its complementary method, linkage analysis, provides direct genetic confirmation, but with limited resolut...

journal_title：BMC biology

authors： Li C,Li Y,Bradbury PJ,Wu X,Shi Y,Song Y,Zhang D,Rodgers-Melnick E,Buckler ES,Zhang Z,Li Y,Wang T

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal muscles of patients ...

journal_title：BMC biology

authors： Strah N,Romano G,Introna C,Klima R,Marzullo M,Ciapponi L,Megighian A,Nizzardo M,Feiguin F

更新日期：2020-03-26 00:00:00

abstract：BACKGROUND:Nucleolar rDNA is tightly associated with silent heterochromatin, which is important for rDNA stability, nucleolar integration, and cellular senescence. Two pathways have been described that lead to rDNA silencing in yeast: 1) the RENT (regulator of nucleolar silencing and telophase exit) complex, which is c...

journal_title：BMC biology

authors： Ryu HY,Ahn S

更新日期：2014-09-24 00:00:00

abstract：BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...

journal_title：BMC biology

authors： Sunagar K,Columbus-Shenkar YY,Fridrich A,Gutkovich N,Aharoni R,Moran Y

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:Effective disease management depends on timely and accurate diagnosis to guide control measures. The capacity to distinguish between individuals in a pathogen population with specific properties such as fungicide resistance, toxin production and virulence profiles is often essential to inform disease managem...

journal_title：BMC biology

authors： Radhakrishnan GV,Cook NM,Bueno-Sancho V,Lewis CM,Persoons A,Mitiku AD,Heaton M,Davey PE,Abeyo B,Alemayehu Y,Badebo A,Barnett M,Bryant R,Chatelain J,Chen X,Dong S,Henriksson T,Holdgate S,Justesen AF,Kalous J,Kang Z

更新日期：2019-08-13 00:00:00

abstract：:A common symbiont of insects, the bacterium Wolbachia has been implicated in phenomena as diverse as sex determination, pathogen defence and speciation and is being used in public health programs to prevent mosquitoes transmitting disease. Despite decades of research, we know remarkably little about how it exerts its ...

journal_title：BMC biology

authors： Jiggins FM

更新日期：2016-10-19 00:00:00

abstract：BACKGROUND:Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living cells. Recently, fluorescence resonance energy transfer (FRET) sensors...

journal_title：BMC biology

authors： Adjobo-Hermans MJ,Goedhart J,van Weeren L,Nijmeijer S,Manders EM,Offermanns S,Gadella TW Jr

更新日期：2011-05-27 00:00:00

abstract：BACKGROUND:A dearth of laboratory tests to study actual human approach-avoidance behavior has complicated translational research on anxiety. The elevated plus-maze (EPM) is the gold standard to assess approach-avoidance behavior in rodents. METHODS:Here, we translated the EPM to humans using mixed reality through a co...

journal_title：BMC biology

authors： Biedermann SV,Biedermann DG,Wenzlaff F,Kurjak T,Nouri S,Auer MK,Wiedemann K,Briken P,Haaker J,Lonsdorf TB,Fuss J

更新日期：2017-12-21 00:00:00

abstract：BACKGROUND:Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system. RESULTS:Adult Spragu...

journal_title：BMC biology

authors： Borlongan CV,Hayashi T,Oeltgen PR,Su TP,Wang Y

更新日期：2009-06-17 00:00:00

abstract：BACKGROUND:Dorsal spine reduction in threespine sticklebacks (Gasterosteus aculeatus) is a classic example of recurrent skeletal evolution in nature. Sticklebacks in marine environments typically have long spines that form part of their skeletal armor. Many derived freshwater populations have evolved shorter spines. Ch...

journal_title：BMC biology

authors： Howes TR,Summers BR,Kingsley DM

更新日期：2017-12-07 00:00:00

abstract：BACKGROUND:Internal tagging of proteins by inserting small functional peptides into surface accessible permissive sites has proven to be an indispensable tool for basic and applied science. Permissive sites are typically identified by transposon mutagenesis on a case-by-case basis, limiting scalability and their exploi...

journal_title：BMC biology

authors： Oesterle S,Roberts TM,Widmer LA,Mustafa H,Panke S,Billerbeck S

更新日期：2017-10-30 00:00:00

abstract：:The vertebrate nervous system is deeply divided into 'somatic' and 'visceral' subsystems that respond to external and internal stimuli, respectively. Molecular characterization of neurons in different groups of mollusks by Nomaksteinsky and colleagues, published in this issue of BMC Biology, reveals that the viscero-s...

journal_title：BMC biology

authors： Bertucci P,Arendt D

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...

journal_title：BMC biology

authors： Cary GA,Wolff A,Zueva O,Pattinato J,Hinman VF

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis of aquatic primary production; most taxa are free-living, while some can form symbiotic and parasiti...

journal_title：BMC biology

authors： Stephens TG,González-Pech RA,Cheng Y,Mohamed AR,Burt DW,Bhattacharya D,Ragan MA,Chan CX

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Marine molluscs, as is the case with most aquatic animals, rely heavily on olfactory cues for survival. In the mollusc Aplysia californica, mate-attraction is mediated by a blend of water-borne protein pheromones that are detected by sensory structures called rhinophores. The expression of G protein and phos...

journal_title：BMC biology

authors： Cummins SF,Erpenbeck D,Zou Z,Claudianos C,Moroz LL,Nagle GT,Degnan BM

更新日期：2009-06-04 00:00:00

abstract：:The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or ch...

journal_title：BMC biology

authors： Nakayama T,Archibald JM

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:One hundred years ago, marine organisms were the dominant systems for the study of developmental biology. The challenges in rearing these organisms outside of a marine setting ultimately contributed to a shift towards work on a smaller number of so-called model systems. Those animals are typically non-marine...

journal_title：BMC biology

authors： Henry JQ,Lesoway MP,Perry KJ

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such as the relatively common neonatal hypertroph...

journal_title：BMC biology

authors： Li Y,Pan J,Wei C,Chen J,Liu Y,Liu J,Zhang X,Evans SM,Cui Y,Cui S

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...

journal_title：BMC biology

authors： Gordon-Keylock S,Medvinsky A

更新日期：2011-12-28 00:00:00

abstract：BACKGROUND:Gene drives based on CRISPR-Cas9 technology are increasingly being considered as tools for reducing the capacity of mosquito populations to transmit malaria, and one of the most promising options is driving endonuclease genes that reduce the fertility of female mosquitoes. In particular, there is much intere...

journal_title：BMC biology

authors： North AR,Burt A,Godfray HCJ

更新日期：2020-08-11 00:00:00

abstract：:CRISPR-Cas systems, the purveyors of adaptive immunity in archaea and bacteria and sources of the new generation of genome engineering tools, have been studied in exquisite molecular detail. However, when it comes to biological functions, ecology, and evolution of CRISPR-Cas, many more intriguing questions remain than...

journal_title：BMC biology

authors： Koonin EV

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is not reversible. A number of methods have been developed to overcome this, but each method has its own limitations. RESULTS:We d...

journal_title：BMC biology

authors： Chaiyachati BH,Kaundal RK,Zhao J,Wu J,Flavell R,Chi T

更新日期：2012-11-30 00:00:00

abstract：BACKGROUND:The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experience-dependent transgenerational inheritance. However, questions remain unanswered as to how heritabl...

journal_title：BMC biology

authors： O'Brien EA,Ensbey KS,Day BW,Baldock PA,Barry G

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：:The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiqu...

journal_title：BMC biology

authors： Sannino S,Brodsky JL

更新日期：2017-11-16 00:00:00