Abstract：
:The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, the response to drug therapy and the rate of generation of HIV variants that escape immune responses. We show how modeling has revealed many dynamical features of HIV infection and how it may provide insight into the ultimate cure for this infection.
journal_name
BMC Bioljournal_title
BMC biologyauthors
Perelson AS,Ribeiro RMdoi
10.1186/1741-7007-11-96subject
Has Abstractpub_date
2013-09-03 00:00:00pages
96issn
1741-7007pii
1741-7007-11-96journal_volume
11pub_type
杂志文章,评审相关文献
BMC BIOLOGY文献大全abstract：BACKGROUND:The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut formation, the model systems Caenorhabditis elegans and Drosophila melanogaster, which belong to th...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-015-0139-z
更新日期：2015-04-21 00:00:00
abstract：BACKGROUND:Although a variety of animals have been used to produce polyclonal antibodies against antigens, the production of antigen-specific monoclonal antibodies from animals remains challenging. RESULTS:We propose a simple and rapid strategy to produce monoclonal antibodies from a variety of animals. By staining ly...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-10-80
更新日期：2012-09-28 00:00:00
abstract：:Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent paper in BMC Systems Biology describes a promising step in this direction. ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-8-48
更新日期：2010-04-28 00:00:00
abstract：:The circadian clock enhances fitness through temporal organization of plant gene expression, metabolism and physiology. Two recent studies, one in BMC Evolutionary Biology, demonstrate through phylogenetic analysis of the CCA1/LHY and TOC1/PRR gene families that the common ancestor of monocots and eudicots had compone...
journal_title：BMC biology
pub_type： 评论,杂志文章,评审
doi：10.1186/1741-7007-8-55
更新日期：2010-05-07 00:00:00
abstract：BACKGROUND:Dorsal spine reduction in threespine sticklebacks (Gasterosteus aculeatus) is a classic example of recurrent skeletal evolution in nature. Sticklebacks in marine environments typically have long spines that form part of their skeletal armor. Many derived freshwater populations have evolved shorter spines. Ch...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-017-0456-5
更新日期：2017-12-07 00:00:00
abstract：BACKGROUND:The ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is intimately linked to gene regulation, much less is known about the...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-7-43
更新日期：2009-07-23 00:00:00
abstract：BACKGROUND:The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple categories of ncRNAs and characterization of the way their expression is regulated. We previously sho...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-0763-0
更新日期：2020-04-13 00:00:00
abstract：BACKGROUND:Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embedded in the gene regulatory networks that orchestrate embryogenesis. Knotted-like homeobox (KNOX) TF...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0605-5
更新日期：2018-11-05 00:00:00
abstract：BACKGROUND:Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0609-1
更新日期：2018-11-20 00:00:00
abstract：:In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0275-0
更新日期：2016-06-23 00:00:00
abstract：BACKGROUND:The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. reinhardtii, yet only two-the channelrhodopsins-were functionally characterized. Characterization of ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0613-5
更新日期：2018-12-06 00:00:00
abstract：BACKGROUND:Gene duplication provides opportunities for lineage diversification and evolution of developmental novelties. Duplicated genes generally either disappear by accumulation of mutations (nonfunctionalization), or are preserved either by the origin of positively selected functions in one or both duplicates (neof...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-6-35
更新日期：2008-08-22 00:00:00
abstract：BACKGROUND:Effective disease management depends on timely and accurate diagnosis to guide control measures. The capacity to distinguish between individuals in a pathogen population with specific properties such as fungicide resistance, toxin production and virulence profiles is often essential to inform disease managem...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0684-y
更新日期：2019-08-13 00:00:00
abstract：:Joel Dacks is an Associate Professor and Canada Research Chair in Evolutionary Cell Biology at the University of Alberta, a Scientific Associate at the Natural History Museum (London), and the current President of the International Society for Evolutionary Protistology. His research group studies the evolution and div...
journal_title：BMC biology
pub_type： 传,历史文章,面试
doi：10.1186/s12915-018-0586-4
更新日期：2018-11-01 00:00:00
abstract：:Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic...
journal_title：BMC biology
pub_type： 面试
doi：10.1186/s12915-014-0100-6
更新日期：2014-11-29 00:00:00
abstract：BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-014-0113-1
更新日期：2015-01-16 00:00:00
abstract：BACKGROUND:Cellular functions can be regulated by cell-cell interactions that are influenced by extra-cellular, density-dependent signaling factors. Dictyostelium grow as individual cells in nutrient-rich sources, but, as nutrients become depleted, they initiate a multi-cell developmental program that is dependent upon...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-019-0714-9
更新日期：2019-12-02 00:00:00
abstract：:The majority of convincingly documented cases of hybridization in angiosperms has involved genetic introgression between the parental species or formation of a hybrid species with increased ploidy; however, homoploid (diploid) hybridization may be just as common. Recent studies, including one in BMC Evolutionary Biolo...
journal_title：BMC biology
pub_type： 社论
doi：10.1186/1741-7007-8-45
更新日期：2010-04-21 00:00:00
abstract：BACKGROUND:Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (AC...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00791-7
更新日期：2020-06-16 00:00:00
abstract：BACKGROUND:Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied on grafting-resistant North American Vitis species as rootstocks, thereby limiting genetic stocks to...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00820-5
更新日期：2020-07-23 00:00:00
abstract：BACKGROUND:Early developmental patterns of flatworms are extremely diverse and difficult to compare between distant groups. In parasitic flatworms, such as tapeworms, this is confounded by highly derived life cycles involving indirect development, and even the true orientation of the tapeworm antero-posterior (AP) axis...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0233-x
更新日期：2016-03-04 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-4-34
更新日期：2006-10-12 00:00:00
abstract：BACKGROUND:Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show d...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-2-16
更新日期：2004-07-08 00:00:00
abstract：:The visual pathway is tasked with processing incoming signals from the retina and converting this information into adaptive behavior. Recent studies of the larval zebrafish tectum have begun to clarify how the 'micro-circuitry' of this highly organized midbrain structure filters visual input, which arrives in the supe...
journal_title：BMC biology
pub_type： 杂志文章,评审
doi：10.1186/1741-7007-8-126
更新日期：2010-09-28 00:00:00
abstract：BACKGROUND:Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development. RESULTS:We report a novel role of Wnt signaling in organogenesis using the format...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/1741-7007-3-23
更新日期：2005-10-24 00:00:00
abstract：BACKGROUND:How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. RESULTS:By exploring the possible effects of v...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-015-0122-8
更新日期：2015-02-19 00:00:00
abstract：:The global spread of SARS-CoV-2 has shaken our health care and economic systems, prompting re-evaluation of long-held views on how best to deliver care. This is especially the case for our global diagnostic strategy. While current laboratory-based centralized RT-qPCR will continue to serve as a gold standard diagnosti...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-020-00891-4
更新日期：2020-10-28 00:00:00
abstract：BACKGROUND:Affinity purification followed by mass spectrometry (AP/MS) is a widely used approach to identify protein interactions and complexes. In multicellular organisms, the accurate identification of protein complexes by AP/MS is complicated by the potential heterogeneity of complexes in different tissues. Here, we...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-016-0286-x
更新日期：2016-08-09 00:00:00
abstract：BACKGROUND:Parkinson's disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission. Here, we evaluate the impact of fo...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0567-7
更新日期：2018-09-10 00:00:00
abstract：BACKGROUND:Genetically encoded calcium ion (Ca2+) indicators (GECIs) are indispensable tools for measuring Ca2+ dynamics and neuronal activities in vitro and in vivo. Red fluorescent protein (RFP)-based GECIs have inherent advantages relative to green fluorescent protein-based GECIs due to the longer wavelength light u...
journal_title：BMC biology
pub_type： 杂志文章
doi：10.1186/s12915-018-0480-0
更新日期：2018-01-16 00:00:00
