Wnt5 signaling in vertebrate pancreas development.

abstract：BACKGROUND:Animal olfactory systems detect volatile environmental chemicals and integrate this information to direct the discovery of food and mates as well as danger avoidance. Rather than remaining constant, olfactory response thresholds are modulated by internal and external cues to adapt odor-guided behaviors to ch...

journal_title：BMC biology

authors： Lee S,Kim YJ,Jones WD

更新日期：2017-05-05 00:00:00

abstract：BACKGROUND:Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is not reversible. A number of methods have been developed to overcome this, but each method has its own limitations. RESULTS:We d...

journal_title：BMC biology

authors： Chaiyachati BH,Kaundal RK,Zhao J,Wu J,Flavell R,Chi T

更新日期：2012-11-30 00:00:00

abstract：BACKGROUND:The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a drivi...

journal_title：BMC biology

authors： North AR,Burt A,Godfray HCJ

更新日期：2019-03-29 00:00:00

abstract：BACKGROUND:O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investi...

journal_title：BMC biology

authors： Okajima T,Reddy B,Matsuda T,Irvine KD

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:The red algae (Rhodophyta) diverged from the green algae and plants (Viridiplantae) over one billion years ago within the kingdom Archaeplastida. These photosynthetic lineages provide an ideal model to study plastid genome reduction in deep time. To this end, we assembled a large dataset of the plastid genom...

journal_title：BMC biology

authors： Lee J,Cho CH,Park SI,Choi JW,Song HS,West JA,Bhattacharya D,Yoon HS

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:A key event in plant morphogenesis is the establishment of a division plane. A plant-specific microtubular preprophase band (PPB) accurately predicts the line of cell division, whereas the phragmoplast, another plant-specific array, executes cell division by maintaining this predicted line. Although establis...

journal_title：BMC biology

authors： Dhonukshe P,Mathur J,Hülskamp M,Gadella TW Jr

更新日期：2005-04-14 00:00:00

abstract：BACKGROUND:The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the functional role of gene-regulation sequences in health and disease. In thi...

journal_title：BMC biology

authors： Schmouth JF,Castellarin M,Laprise S,Banks KG,Bonaguro RJ,McInerny SC,Borretta L,Amirabbasi M,Korecki AJ,Portales-Casamar E,Wilson G,Dreolini L,Jones SJ,Wasserman WW,Goldowitz D,Holt RA,Simpson EM

更新日期：2013-10-14 00:00:00

abstract：BACKGROUND:Dinoflagellates are taxonomically diverse and ecologically important phytoplankton that are ubiquitously present in marine and freshwater environments. Mostly photosynthetic, dinoflagellates provide the basis of aquatic primary production; most taxa are free-living, while some can form symbiotic and parasiti...

journal_title：BMC biology

authors： Stephens TG,González-Pech RA,Cheng Y,Mohamed AR,Burt DW,Bhattacharya D,Ragan MA,Chan CX

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest that this conversion occurs via a cholesterol-sensitive process, as chol...

journal_title：BMC biology

authors： Bate C,Tayebi M,Diomede L,Salmona M,Williams A

更新日期：2008-09-12 00:00:00

abstract：BACKGROUND:Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mi...

journal_title：BMC biology

authors： Ashmore T,Roberts LD,Morash AJ,Kotwica AO,Finnerty J,West JA,Murfitt SA,Fernandez BO,Branco C,Cowburn AS,Clarke K,Johnson RS,Feelisch M,Griffin JL,Murray AJ

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all...

journal_title：BMC biology

authors： Volkers RJ,Snoek LB,Hubar CJ,Coopman R,Chen W,Yang W,Sterken MG,Schulenburg H,Braeckman BP,Kammenga JE

更新日期：2013-08-19 00:00:00

abstract：BACKGROUND:Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Ye...

journal_title：BMC biology

authors： Bellesi M,de Vivo L,Tononi G,Cirelli C

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:Drosophila melanogaster has served as a powerful model system for genetic studies of courtship songs. To accelerate research on the genetic and neural mechanisms underlying courtship song, we have developed a sensitive recording system to simultaneously capture the acoustic signals from 32 separate pairs of ...

journal_title：BMC biology

authors： Arthur BJ,Sunayama-Morita T,Coen P,Murthy M,Stern DL

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS:As a proof of principle, we show in both cell lines and primary cell cultu...

journal_title：BMC biology

authors： Bouquier N,Moutin E,Tintignac LA,Reverbel A,Jublanc E,Sinnreich M,Chastagnier Y,Averous J,Fafournoux P,Verpelli C,Boeckers T,Carnac G,Perroy J,Ollendorff V

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：:Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous e...

journal_title：BMC biology

authors： Nussinov R,Ma B

更新日期：2012-01-25 00:00:00

abstract：BACKGROUND:Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the number of non-coding RNAs identified in various organisms. While we have mechanistic underst...

journal_title：BMC biology

authors： Akay A,Jordan D,Navarro IC,Wrzesinski T,Ponting CP,Miska EA,Haerty W

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Conservation of the spatial binding organizations at the level of physico-chemical interactions is important for the formation and stability of protein-protein complexes as well as protein and drug design. Due to the lack of computational tools for recognition of spatial patterns of interactions shared by a ...

journal_title：BMC biology

authors： Shulman-Peleg A,Shatsky M,Nussinov R,Wolfson HJ

更新日期：2007-10-09 00:00:00

abstract：BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...

journal_title：BMC biology

authors： Zeng J,Howard JC

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embedded in the gene regulatory networks that orchestrate embryogenesis. Knotted-like homeobox (KNOX) TF...

journal_title：BMC biology

authors： Joo S,Wang MH,Lui G,Lee J,Barnas A,Kim E,Sudek S,Worden AZ,Lee JH

更新日期：2018-11-05 00:00:00

abstract：:The elevated metabolic requirements of cancer cells reflect their rapid growth and proliferation and are met through mutations in oncogenes and tumor suppressor genes that reprogram cellular processes. For example, in tuberous sclerosis complex (TSC)-related tumors, the loss of TSC1/2 function causes constitutive mTOR...

journal_title：BMC biology

authors： Csibi A,Blenis J

更新日期：2011-10-21 00:00:00

abstract：BACKGROUND:Pneumococcal meningitis is associated with high mortality (approximately 30%) and morbidity. Up to 50% of survivors are affected by neurological sequelae due to a wide spectrum of brain injury mainly affecting the cortex and hippocampus. Despite this significant disease burden, the genetic program that regul...

journal_title：BMC biology

authors： Coimbra RS,Voisin V,de Saizieu AB,Lindberg RL,Wittwer M,Leppert D,Leib SL

更新日期：2006-06-02 00:00:00

abstract：BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...

journal_title：BMC biology

authors： Le Roy T,Lécuyer E,Chassaing B,Rhimi M,Lhomme M,Boudebbouze S,Ichou F,Haro Barceló J,Huby T,Guerin M,Giral P,Maguin E,Kapel N,Gérard P,Clément K,Lesnik P

更新日期：2019-11-27 00:00:00

abstract：:Exosomes are extracellular vesicles first described as such 30 years ago and since implicated in cell-cell communication and the transmission of disease states, and explored as a means of drug discovery. Yet fundamental questions about their biology remain unanswered. Here I explore what exosomes are, highlight the di...

journal_title：BMC biology

authors： Edgar JR

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Sexual reproduction entails the encounter of the sexes and the multiplicity of rituals is parallel to the diversity of mating systems. Evolutionary mechanisms such as sexual selection and sexual conflict have led to the elaboration of traits to gain attention and favours from potential partners. A paradox ex...

journal_title：BMC biology

authors： Lassance JM,Löfstedt C

更新日期：2009-03-03 00:00:00

abstract：BACKGROUND:The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant ...

journal_title：BMC biology

authors： Boursereau R,Abou-Samra M,Lecompte S,Noel L,Brichard SM

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potential confounder of these sequence-based approaches is the presence of contamination in DNA extraction ...

journal_title：BMC biology

authors： Salter SJ,Cox MJ,Turek EM,Calus ST,Cookson WO,Moffatt MF,Turner P,Parkhill J,Loman NJ,Walker AW

更新日期：2014-11-12 00:00:00

abstract：:Few would argue that science is better done in silos, with no transparency or sharing of methods and resources. Yet scientists and scientific stakeholders (e.g., academic institutions, funding agencies, journals) alike continue to find themselves at a relative impasse in the implementation of open science practices, s...

journal_title：BMC biology

authors： Milham MP,Klein A

更新日期：2019-03-27 00:00:00

abstract：BACKGROUND:The traditional concept that heritability occurs exclusively from the transfer of germline-restricted genetics is being challenged by the increasing accumulation of evidence confirming the existence of experience-dependent transgenerational inheritance. However, questions remain unanswered as to how heritabl...

journal_title：BMC biology

authors： O'Brien EA,Ensbey KS,Day BW,Baldock PA,Barry G

更新日期：2020-04-30 00:00:00

abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...

journal_title：BMC biology

authors： Gordon-Keylock S,Medvinsky A

更新日期：2011-12-28 00:00:00