Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida.

abstract：BACKGROUND:Polycomb-group genes (PcG) encode proteins that maintain homeotic (Hox) gene repression throughout development. Conversely, trithorax-group (trxG) genes encode positive factors required for maintenance of long term Hox gene activation. Both kinds of factors bind chromatin regions called maintenance elements ...

journal_title：BMC biology

authors： Salvaing J,Decoville M,Mouchel-Vielh E,Bussière M,Daulny A,Boldyreva L,Zhimulev I,Locker D,Peronnet F

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...

journal_title：BMC biology

authors： Beckmann A,Xiao S,Müller JP,Mercadante D,Nüchter T,Kröger N,Langhojer F,Petrich W,Holstein TW,Benoit M,Gräter F,Özbek S

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...

journal_title：BMC biology

authors： Cary GA,Wolff A,Zueva O,Pattinato J,Hinman VF

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:Mitochondrial DNA (mtDNA) haplotypes have become popular tools for tracing maternal ancestry, and several companies offer this service to the general public. Numerous studies have demonstrated that human mtDNA haplotypes can be used with confidence to identify the continent where the haplotype originated. Id...

journal_title：BMC biology

authors： Ely B,Wilson JL,Jackson F,Jackson BA

更新日期：2006-10-12 00:00:00

abstract：BACKGROUND:Male sexually selected vocalisations generally contain both individuality and quality cues that are crucial in intra- as well as inter-sexual communication. As individuality is a fixed feature whereas male phenotypic quality changes with age, individuality and quality cues may be subjected to different selec...

journal_title：BMC biology

authors： Briefer E,Vannoni E,McElligott AG

更新日期：2010-04-09 00:00:00

abstract：BACKGROUND:Sexual reproduction entails the encounter of the sexes and the multiplicity of rituals is parallel to the diversity of mating systems. Evolutionary mechanisms such as sexual selection and sexual conflict have led to the elaboration of traits to gain attention and favours from potential partners. A paradox ex...

journal_title：BMC biology

authors： Lassance JM,Löfstedt C

更新日期：2009-03-03 00:00:00

abstract：:Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous e...

journal_title：BMC biology

authors： Nussinov R,Ma B

更新日期：2012-01-25 00:00:00

abstract：BACKGROUND:Eukaryotic genome assembly remains a challenge in part due to the prevalence of complex DNA repeats. This is a particularly acute problem for holocentric nematodes because of the large number of satellite DNA sequences found throughout their genomes. These have been recalcitrant to most genome sequencing met...

journal_title：BMC biology

authors： Eccles D,Chandler J,Camberis M,Henrissat B,Koren S,Le Gros G,Ewbank JJ

更新日期：2018-01-11 00:00:00

abstract：:The evolution of plastids from cyanobacteria is believed to represent a singularity in the history of life. The enigmatic amoeba Paulinella and its 'recently' acquired photosynthetic inclusions provide a fascinating system through which to gain fresh insight into how endosymbionts become organelles.The plastids, or ch...

journal_title：BMC biology

authors： Nakayama T,Archibald JM

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system. RESULTS:Adult Spragu...

journal_title：BMC biology

authors： Borlongan CV,Hayashi T,Oeltgen PR,Su TP,Wang Y

更新日期：2009-06-17 00:00:00

abstract：:The vertebrate nervous system is deeply divided into 'somatic' and 'visceral' subsystems that respond to external and internal stimuli, respectively. Molecular characterization of neurons in different groups of mollusks by Nomaksteinsky and colleagues, published in this issue of BMC Biology, reveals that the viscero-s...

journal_title：BMC biology

authors： Bertucci P,Arendt D

更新日期：2013-04-30 00:00:00

abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...

journal_title：BMC biology

authors： Gordon-Keylock S,Medvinsky A

更新日期：2011-12-28 00:00:00

abstract：BACKGROUND:The ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is intimately linked to gene regulation, much less is known about the...

journal_title：BMC biology

authors： Hui JH,Raible F,Korchagina N,Dray N,Samain S,Magdelenat G,Jubin C,Segurens B,Balavoine G,Arendt D,Ferrier DE

更新日期：2009-07-23 00:00:00

abstract：BACKGROUND:Root and tuber crops are a major food source in tropical Africa. Among these crops are several species in the monocotyledonous genus Dioscorea collectively known as yam, a staple tuber crop that contributes enormously to the subsistence and socio-cultural lives of millions of people, principally in West and ...

journal_title：BMC biology

authors： Tamiru M,Natsume S,Takagi H,White B,Yaegashi H,Shimizu M,Yoshida K,Uemura A,Oikawa K,Abe A,Urasaki N,Matsumura H,Babil P,Yamanaka S,Matsumoto R,Muranaka S,Girma G,Lopez-Montes A,Gedil M,Bhattacharjee R,Abberton M

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Seed plants are composed of angiosperms and gymnosperms, which diverged from each other around 300 million years ago. While much light has been shed on the mechanisms and rate of genome evolution in flowering plants, such knowledge remains conspicuously meagre for the gymnosperms. Conifers are key representa...

journal_title：BMC biology

authors： Pavy N,Pelgas B,Laroche J,Rigault P,Isabel N,Bousquet J

更新日期：2012-10-26 00:00:00

abstract：:Molecular interaction networks provide a window on the workings of the cell. However, combining various types of networks into one coherent large-scale dynamic model remains a formidable challenge. A recent paper in BMC Systems Biology describes a promising step in this direction. ...

journal_title：BMC biology

authors： Przytycka TM,Kim YA

更新日期：2010-04-28 00:00:00

abstract：BACKGROUND:Although a variety of animals have been used to produce polyclonal antibodies against antigens, the production of antigen-specific monoclonal antibodies from animals remains challenging. RESULTS:We propose a simple and rapid strategy to produce monoclonal antibodies from a variety of animals. By staining ly...

journal_title：BMC biology

authors： Kurosawa N,Yoshioka M,Fujimoto R,Yamagishi F,Isobe M

更新日期：2012-09-28 00:00:00

abstract：BACKGROUND:Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not been carried out. RESULTS:Through an RNA interference screen, and using a prosta...

journal_title：BMC biology

authors： Tajadura-Ortega V,Garg R,Allen R,Owczarek C,Bright MD,Kean S,Mohd-Noor A,Grigoriadis A,Elston TC,Hahn KM,Ridley AJ

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane repair. Distinct from other cytoskeletal filaments, ESCRT-III filam...

journal_title：BMC biology

authors： Harker-Kirschneck L,Baum B,Šarić AE

更新日期：2019-10-22 00:00:00

abstract：BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...

journal_title：BMC biology

authors： Sunagar K,Columbus-Shenkar YY,Fridrich A,Gutkovich N,Aharoni R,Moran Y

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis, which triggers the induction of a subset of P. aeruginosa-response genes in the nematode Caenorhabdit...

journal_title：BMC biology

authors： McEwan DL,Feinbaum RL,Stroustrup N,Haas W,Conery AL,Anselmo A,Sadreyev R,Ausubel FM

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins. RESULTS:Here we mined the human proteome and identified the membrane proteome subset using three prediction tools for alpha-hel...

journal_title：BMC biology

authors： Almén MS,Nordström KJ,Fredriksson R,Schiöth HB

更新日期：2009-08-13 00:00:00

abstract：BACKGROUND:mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS:As a proof of principle, we show in both cell lines and primary cell cultu...

journal_title：BMC biology

authors： Bouquier N,Moutin E,Tintignac LA,Reverbel A,Jublanc E,Sinnreich M,Chastagnier Y,Averous J,Fafournoux P,Verpelli C,Boeckers T,Carnac G,Perroy J,Ollendorff V

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the polyploid nature, high genome complexity and lack of genomic sequence integration with reproductive tiss...

journal_title：BMC biology

authors： Rabiger DS,Taylor JM,Spriggs A,Hand ML,Henderson ST,Johnson SD,Oelkers K,Hrmova M,Saito K,Suzuki G,Mukai Y,Carroll BJ,Koltunow AM

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd gen...

journal_title：BMC biology

authors： Ignesti M,Barraco M,Nallamothu G,Woolworth JA,Duchi S,Gargiulo G,Cavaliere V,Hsu T

更新日期：2014-02-14 00:00:00

abstract：:Rino Rappuoli is a graduate of Siena University, where he also earned his PhD before moving to the Sclavo Research Center, the Italian vaccine institute, also in Siena. He then spent two years in the USA, mostly at Harvard with John Murphy and Alwin Pappenheimer working on a new diphtheria vaccine based on a non-toxic...

journal_title：BMC biology

authors： Rappuoli R

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut formation, the model systems Caenorhabditis elegans and Drosophila melanogaster, which belong to th...

journal_title：BMC biology

authors： Martín-Durán JM,Hejnol A

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development. RESULTS:We report a novel role of Wnt signaling in organogenesis using the format...

journal_title：BMC biology

authors： Kim HJ,Schleiffarth JR,Jessurun J,Sumanas S,Petryk A,Lin S,Ekker SC

更新日期：2005-10-24 00:00:00

abstract：BACKGROUND:Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Ye...

journal_title：BMC biology

authors： Bellesi M,de Vivo L,Tononi G,Cirelli C

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00