Microtubule plus-ends reveal essential links between intracellular polarization and localized modulation of endocytosis during division-plane establishment in plant cells.

abstract：:This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding sites, the enhancement of traditional virtual-screening methodolog...

journal_title：BMC biology

authors： Durrant JD,McCammon JA

更新日期：2011-10-28 00:00:00

abstract：:Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...

journal_title：BMC biology

authors： Keller A

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Gastrointestinal tract dysfunction is one of the non-motor features, where constipation is reported as the most common gastrointestinal symptom. Aromatic bacterial metabolites are attracti...

journal_title：BMC biology

authors： van Kessel SP,de Jong HR,Winkel SL,van Leeuwen SS,Nelemans SA,Permentier H,Keshavarzian A,El Aidy S

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：BACKGROUND:Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development. RESULTS:We report a novel role of Wnt signaling in organogenesis using the format...

journal_title：BMC biology

authors： Kim HJ,Schleiffarth JR,Jessurun J,Sumanas S,Petryk A,Lin S,Ekker SC

更新日期：2005-10-24 00:00:00

abstract：BACKGROUND:Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all...

journal_title：BMC biology

authors： Volkers RJ,Snoek LB,Hubar CJ,Coopman R,Chen W,Yang W,Sterken MG,Schulenburg H,Braeckman BP,Kammenga JE

更新日期：2013-08-19 00:00:00

abstract：BACKGROUND:Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show d...

journal_title：BMC biology

authors： Frank SA

更新日期：2004-07-08 00:00:00

abstract：BACKGROUND:The western flower thrips, Frankliniella occidentalis (Pergande), is a globally invasive pest and plant virus vector on a wide array of food, fiber, and ornamental crops. The underlying genetic mechanisms of the processes governing thrips pest and vector biology, feeding behaviors, ecology, and insecticide r...

journal_title：BMC biology

authors： Rotenberg D,Baumann AA,Ben-Mahmoud S,Christiaens O,Dermauw W,Ioannidis P,Jacobs CGC,Vargas Jentzsch IM,Oliver JE,Poelchau MF,Rajarapu SP,Schneweis DJ,Snoeck S,Taning CNT,Wei D,Widana Gamage SMK,Hughes DST,Murali SC,Ba

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...

journal_title：BMC biology

authors： Zeng J,Howard JC

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such as the relatively common neonatal hypertroph...

journal_title：BMC biology

authors： Li Y,Pan J,Wei C,Chen J,Liu Y,Liu J,Zhang X,Evans SM,Cui Y,Cui S

更新日期：2014-03-27 00:00:00

abstract：:Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core molecular elements of the ethylene-signaling pathway have been uncovered, re...

journal_title：BMC biology

authors： Chang C

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Drosophila melanogaster has served as a powerful model system for genetic studies of courtship songs. To accelerate research on the genetic and neural mechanisms underlying courtship song, we have developed a sensitive recording system to simultaneously capture the acoustic signals from 32 separate pairs of ...

journal_title：BMC biology

authors： Arthur BJ,Sunayama-Morita T,Coen P,Murthy M,Stern DL

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Phylostratigraphy is a method used to correlate the evolutionary origin of founder genes (that is, functional founder protein domains) of gene families with particular macroevolutionary transitions. It is based on a model of genome evolution that suggests that the origin of complex phenotypic innovations wil...

journal_title：BMC biology

authors： Domazet-Loso T,Tautz D

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain is also elicited by natural rewards and incentive cues, raising the possibility that some CRF systems in the brain mediate an independent function of positiv...

journal_title：BMC biology

authors： Peciña S,Schulkin J,Berridge KC

更新日期：2006-04-13 00:00:00

abstract：BACKGROUND:The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal muscles of patients ...

journal_title：BMC biology

authors： Strah N,Romano G,Introna C,Klima R,Marzullo M,Ciapponi L,Megighian A,Nizzardo M,Feiguin F

更新日期：2020-03-26 00:00:00

abstract：BACKGROUND:Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epithelial cells are relatively well studied, molecular markers of lung mesenchymal cells and the genetic...

journal_title：BMC biology

authors： Zhang W,Menke DB,Jiang M,Chen H,Warburton D,Turcatel G,Lu CH,Xu W,Luo Y,Shi W

更新日期：2013-11-13 00:00:00

abstract：:The mitogen-activated protein kinase p38 (p38 MAPK) is activated by a number of stresses. A recent study in BMC Genomics has uncovered the early transcriptional responses to three types of stress and has demonstrated a central role for p38 MAPK in mediating these responses. See research article http://www.biomedcentra...

journal_title：BMC biology

authors： Whitmarsh AJ

更新日期：2010-04-27 00:00:00

abstract：:The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mou...

journal_title：BMC biology

authors： Bell G

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...

journal_title：BMC biology

authors： Le Roy T,Lécuyer E,Chassaing B,Rhimi M,Lhomme M,Boudebbouze S,Ichou F,Haro Barceló J,Huby T,Guerin M,Giral P,Maguin E,Kapel N,Gérard P,Clément K,Lesnik P

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Genetically encoded calcium ion (Ca2+) indicators (GECIs) are indispensable tools for measuring Ca2+ dynamics and neuronal activities in vitro and in vivo. Red fluorescent protein (RFP)-based GECIs have inherent advantages relative to green fluorescent protein-based GECIs due to the longer wavelength light u...

journal_title：BMC biology

authors： Shen Y,Dana H,Abdelfattah AS,Patel R,Shea J,Molina RS,Rawal B,Rancic V,Chang YF,Wu L,Chen Y,Qian Y,Wiens MD,Hambleton N,Ballanyi K,Hughes TE,Drobizhev M,Kim DS,Koyama M,Schreiter ER,Campbell RE

更新日期：2018-01-16 00:00:00

abstract：:The five most pervasive anthropogenic threats to biodiversity are over-exploitation, habitat changes, climate change, invasive species, and pollution. Since all of these threats can affect intraspecific biodiversity-including genetic variation within populations-humans have the potential to induce contemporary microev...

journal_title：BMC biology

authors： Pelletier F,Coltman DW

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:Loss of photosynthesis has occurred independently in several plant and algal lineages, and represents a major metabolic shift with potential consequences for the content and structure of plastid genomes. To investigate such changes, we sequenced the complete plastid genome of the parasitic, non-photosyntheti...

journal_title：BMC biology

authors： de Koning AP,Keeling PJ

更新日期：2006-04-21 00:00:00

abstract：:Animal domestication has fascinated biologists since Charles Darwin first drew the parallel between evolution via natural selection and human-mediated breeding of livestock and companion animals. In this review we show how studies of ancient DNA from domestic animals and their wild progenitors and congeners have shed ...

journal_title：BMC biology

authors： McHugo GP,Dover MJ,MacHugh DE

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous screen identified protein kinase C delta (PKCδ) as a potential ARTD10 substrate, amo...

journal_title：BMC biology

authors： Tian Y,Korn P,Tripathi P,Komnig D,Wiemuth D,Nikouee A,Classen A,Bolm C,Falkenburger BH,Lüscher B,Gründer S

更新日期：2020-10-15 00:00:00

abstract：:Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous e...

journal_title：BMC biology

authors： Nussinov R,Ma B

更新日期：2012-01-25 00:00:00

abstract：BACKGROUND:Dorsal spine reduction in threespine sticklebacks (Gasterosteus aculeatus) is a classic example of recurrent skeletal evolution in nature. Sticklebacks in marine environments typically have long spines that form part of their skeletal armor. Many derived freshwater populations have evolved shorter spines. Ch...

journal_title：BMC biology

authors： Howes TR,Summers BR,Kingsley DM

更新日期：2017-12-07 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：BACKGROUND:Gene duplication provides opportunities for lineage diversification and evolution of developmental novelties. Duplicated genes generally either disappear by accumulation of mutations (nonfunctionalization), or are preserved either by the origin of positively selected functions in one or both duplicates (neof...

journal_title：BMC biology

authors： Bassham S,Cañestro C,Postlethwait JH

更新日期：2008-08-22 00:00:00

abstract：BACKGROUND:Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species a...

journal_title：BMC biology

authors： Päivinen J,Grapputo A,Kaitala V,Komonen A,Kotiaho JS,Saarinen K,Wahlberg N

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Nucleostemin is a nucleolus residing GTPase that is considered to be an important cancer stem/progenitor cell marker protein due to its high expression levels in breast cancer stem cells and its role in tumor-initiation of human mammary tumor cells. It has been proposed that nucleostemin may represent a valu...

journal_title：BMC biology

authors： Tin AS,Park AH,Sundar SN,Firestone GL

更新日期：2014-09-12 00:00:00