Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.

abstract：BACKGROUND:TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors. RES...

journal_title：BMC biology

authors： Lammirato A,Patsch K,Feiereisen F,Maly K,Nofziger C,Paulmichl M,Hackl H,Trajanoski Z,Valovka T,Huber LA,Vietor I

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mi...

journal_title：BMC biology

authors： Ashmore T,Roberts LD,Morash AJ,Kotwica AO,Finnerty J,West JA,Murfitt SA,Fernandez BO,Branco C,Cowburn AS,Clarke K,Johnson RS,Feelisch M,Griffin JL,Murray AJ

更新日期：2015-12-22 00:00:00

abstract：:The five most pervasive anthropogenic threats to biodiversity are over-exploitation, habitat changes, climate change, invasive species, and pollution. Since all of these threats can affect intraspecific biodiversity-including genetic variation within populations-humans have the potential to induce contemporary microev...

journal_title：BMC biology

authors： Pelletier F,Coltman DW

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:A key event in plant morphogenesis is the establishment of a division plane. A plant-specific microtubular preprophase band (PPB) accurately predicts the line of cell division, whereas the phragmoplast, another plant-specific array, executes cell division by maintaining this predicted line. Although establis...

journal_title：BMC biology

authors： Dhonukshe P,Mathur J,Hülskamp M,Gadella TW Jr

更新日期：2005-04-14 00:00:00

abstract：:Chemosensory receptor genes encode G protein-coupled receptors with which animals sense their chemical environment. The large number of chemosensory receptor genes in the genome and their extreme genetic variability pose unusual challenges for understanding their evolution and function. Two articles in BMC Genomics ex...

journal_title：BMC biology

authors： Keller A

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:The green algae Chlamydomonas reinhardtii and Volvox carteri are important models for studying light perception and response, expressing many different photoreceptors. More than 10 opsins were reported in C. reinhardtii, yet only two-the channelrhodopsins-were functionally characterized. Characterization of ...

journal_title：BMC biology

authors： Tian Y,Gao S,von der Heyde EL,Hallmann A,Nagel G

更新日期：2018-12-06 00:00:00

abstract：BACKGROUND:The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a drivi...

journal_title：BMC biology

authors： North AR,Burt A,Godfray HCJ

更新日期：2019-03-29 00:00:00

abstract：BACKGROUND:The ParaHox gene cluster is the evolutionary sister to the Hox cluster. Whilst the role of the Hox cluster in patterning the anterior-posterior axis of bilaterian animals is well established, and the organisation of vertebrate Hox clusters is intimately linked to gene regulation, much less is known about the...

journal_title：BMC biology

authors： Hui JH,Raible F,Korchagina N,Dray N,Samain S,Magdelenat G,Jubin C,Segurens B,Balavoine G,Arendt D,Ferrier DE

更新日期：2009-07-23 00:00:00

abstract：:The authors of this paper were interested to see whether the expression of three proteins (A, B and C) was altered in a knockout mouse model of a gene encoding Protein X. Each experiment measured the expression of a different protein and the results seem to show a clear increase in protein expression in the mutant mou...

journal_title：BMC biology

authors： Bell G

更新日期：2016-04-07 00:00:00

abstract：BACKGROUND:The internal organization of cells depends on mechanisms to ensure that transport carriers, such as vesicles, fuse only with the correct destination organelle. Several types of proteins have been proposed to confer specificity to this process, and we have recently shown that a set of coiled-coil proteins on ...

journal_title：BMC biology

authors： Wong M,Gillingham AK,Munro S

更新日期：2017-01-26 00:00:00

abstract：BACKGROUND:Genetically encoded calcium ion (Ca2+) indicators (GECIs) are indispensable tools for measuring Ca2+ dynamics and neuronal activities in vitro and in vivo. Red fluorescent protein (RFP)-based GECIs have inherent advantages relative to green fluorescent protein-based GECIs due to the longer wavelength light u...

journal_title：BMC biology

authors： Shen Y,Dana H,Abdelfattah AS,Patel R,Shea J,Molina RS,Rawal B,Rancic V,Chang YF,Wu L,Chen Y,Qian Y,Wiens MD,Hambleton N,Ballanyi K,Hughes TE,Drobizhev M,Kim DS,Koyama M,Schreiter ER,Campbell RE

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd gen...

journal_title：BMC biology

authors： Ignesti M,Barraco M,Nallamothu G,Woolworth JA,Duchi S,Gargiulo G,Cavaliere V,Hsu T

更新日期：2014-02-14 00:00:00

abstract：BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...

journal_title：BMC biology

authors： Sunagar K,Columbus-Shenkar YY,Fridrich A,Gutkovich N,Aharoni R,Moran Y

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:Accurate determination of mouse positions from video data is crucial for various types of behavioral analyses. While detection of body positions is straightforward, the correct identification of nose positions, usually more informative, is far more challenging. The difficulty is largely due to variability in...

journal_title：BMC biology

authors： Ben-Shaul Y

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Humans die at an increasing rate until late in life, when mortality rates level off. The causes of the late-life mortality plateau have been debated extensively over the past few years. Here, I examine mortality patterns separately for each of the leading causes of death. The different causes of death show d...

journal_title：BMC biology

authors： Frank SA

更新日期：2004-07-08 00:00:00

abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...

journal_title：BMC biology

authors： Huminiecki L,Heldin CH

更新日期：2010-12-13 00:00:00

abstract：:This review discusses the many roles atomistic computer simulations of macromolecular (for example, protein) receptors and their associated small-molecule ligands can play in drug discovery, including the identification of cryptic or allosteric binding sites, the enhancement of traditional virtual-screening methodolog...

journal_title：BMC biology

authors： Durrant JD,McCammon JA

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...

journal_title：BMC biology

authors： Zeng J,Howard JC

更新日期：2010-11-30 00:00:00

abstract：BACKGROUND:Within chromatin, the histone variant H2A.Z plays a role in many diverse nuclear processes including transcription, preventing the spread of heterochromatin and epigenetic transcriptional memory. The molecular mechanisms of how H2A.Z mediates its effects are not entirely understood. However, it is now known ...

journal_title：BMC biology

authors： Dryhurst D,Ishibashi T,Rose KL,Eirín-López JM,McDonald D,Silva-Moreno B,Veldhoen N,Helbing CC,Hendzel MJ,Shabanowitz J,Hunt DF,Ausió J

更新日期：2009-12-14 00:00:00

abstract：:Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcriptio...

journal_title：BMC biology

authors： Koonin EV,Krupovic M,Ishino S,Ishino Y

更新日期：2020-06-09 00:00:00

abstract：:Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core molecular elements of the ethylene-signaling pathway have been uncovered, re...

journal_title：BMC biology

authors： Chang C

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the number of non-coding RNAs identified in various organisms. While we have mechanistic underst...

journal_title：BMC biology

authors： Akay A,Jordan D,Navarro IC,Wrzesinski T,Ponting CP,Miska EA,Haerty W

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:The advent of next generation sequencing (NGS) has allowed the discovery of short and long non-coding RNAs (ncRNAs) in an unbiased manner using reverse genetics approaches, enabling the discovery of multiple categories of ncRNAs and characterization of the way their expression is regulated. We previously sho...

journal_title：BMC biology

authors： Cherlin T,Magee R,Jing Y,Pliatsika V,Loher P,Rigoutsos I

更新日期：2020-04-13 00:00:00

abstract：BACKGROUND:Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system. RESULTS:Adult Spragu...

journal_title：BMC biology

authors： Borlongan CV,Hayashi T,Oeltgen PR,Su TP,Wang Y

更新日期：2009-06-17 00:00:00

abstract：BACKGROUND:Microarray analysis and 454 cDNA sequencing were used to investigate a centuries-old problem in regenerative biology: the basis of nerve-dependent limb regeneration in salamanders. Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14...

journal_title：BMC biology

authors： Monaghan JR,Epp LG,Putta S,Page RB,Walker JA,Beachy CK,Zhu W,Pao GM,Verma IM,Hunter T,Bryant SV,Gardiner DM,Harkins TT,Voss SR

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:Drosophila melanogaster has served as a powerful model system for genetic studies of courtship songs. To accelerate research on the genetic and neural mechanisms underlying courtship song, we have developed a sensitive recording system to simultaneously capture the acoustic signals from 32 separate pairs of ...

journal_title：BMC biology

authors： Arthur BJ,Sunayama-Morita T,Coen P,Murthy M,Stern DL

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Phylostratigraphy is a method used to correlate the evolutionary origin of founder genes (that is, functional founder protein domains) of gene families with particular macroevolutionary transitions. It is based on a model of genome evolution that suggests that the origin of complex phenotypic innovations wil...

journal_title：BMC biology

authors： Domazet-Loso T,Tautz D

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Because "laws of nature" do not exist in ecology, much of the foundations of community ecology rely on broad statistical generalisations. One of the strongest generalisations is the positive relationship between density and distribution within a given taxonomic assemblage; that is, locally abundant species a...

journal_title：BMC biology

authors： Päivinen J,Grapputo A,Kaitala V,Komonen A,Kotiaho JS,Saarinen K,Wahlberg N

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest that this conversion occurs via a cholesterol-sensitive process, as chol...

journal_title：BMC biology

authors： Bate C,Tayebi M,Diomede L,Salmona M,Williams A

更新日期：2008-09-12 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00