A central role for p38 MAPK in the early transcriptional response to stress.

abstract：BACKGROUND:How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. RESULTS:By exploring the possible effects of v...

journal_title：BMC biology

authors： Buzi G,Lander AD,Khammash M

更新日期：2015-02-19 00:00:00

abstract：:The global spread of SARS-CoV-2 has shaken our health care and economic systems, prompting re-evaluation of long-held views on how best to deliver care. This is especially the case for our global diagnostic strategy. While current laboratory-based centralized RT-qPCR will continue to serve as a gold standard diagnosti...

journal_title：BMC biology

authors： Matthews Q,da Silva SJR,Norouzi M,Pena LJ,Pardee K

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:Collective neural crest cell migration is critical to the form and function of the vertebrate face and neck, distributing bone, cartilage, and nerve cells into peripheral targets that are intimately linked with head vasculature. The vasculature and neural crest structures are ultimately linked, but when and ...

journal_title：BMC biology

authors： McKinney MC,McLennan R,Kulesa PM

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic te...

journal_title：BMC biology

authors： Fuchs S,Bundy JG,Davies SK,Viney JM,Swire JS,Leroi AM

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:Whole genome duplication (WGD) is a special case of gene duplication, observed rarely in animals, whereby all genes duplicate simultaneously through polyploidisation. Two rounds of WGD (2R-WGD) occurred at the base of vertebrates, giving rise to an enormous wave of genetic novelty, but a systematic analysis ...

journal_title：BMC biology

authors： Huminiecki L,Heldin CH

更新日期：2010-12-13 00:00:00

abstract：BACKGROUND:mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS:As a proof of principle, we show in both cell lines and primary cell cultu...

journal_title：BMC biology

authors： Bouquier N,Moutin E,Tintignac LA,Reverbel A,Jublanc E,Sinnreich M,Chastagnier Y,Averous J,Fafournoux P,Verpelli C,Boeckers T,Carnac G,Perroy J,Ollendorff V

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle called cnidocyst that is important for prey capture and anti-predator defense. An extraordinary morphological and functional complexity of the cnidocysts has inspired numerous studies to investigate their ...

journal_title：BMC biology

authors： Sunagar K,Columbus-Shenkar YY,Fridrich A,Gutkovich N,Aharoni R,Moran Y

更新日期：2018-09-27 00:00:00

abstract：BACKGROUND:Microarray analysis and 454 cDNA sequencing were used to investigate a centuries-old problem in regenerative biology: the basis of nerve-dependent limb regeneration in salamanders. Innervated (NR) and denervated (DL) forelimbs of Mexican axolotls were amputated and transcripts were sampled after 0, 5, and 14...

journal_title：BMC biology

authors： Monaghan JR,Epp LG,Putta S,Page RB,Walker JA,Beachy CK,Zhu W,Pao GM,Verma IM,Hunter T,Bryant SV,Gardiner DM,Harkins TT,Voss SR

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potential confounder of these sequence-based approaches is the presence of contamination in DNA extraction ...

journal_title：BMC biology

authors： Salter SJ,Cox MJ,Turek EM,Calus ST,Cookson WO,Moffatt MF,Turner P,Parkhill J,Loman NJ,Walker AW

更新日期：2014-11-12 00:00:00

abstract：:The efficient production, folding, and secretion of proteins is critical for cancer cell survival. However, cancer cells thrive under stress conditions that damage proteins, so many cancer cells overexpress molecular chaperones that facilitate protein folding and target misfolded proteins for degradation via the ubiqu...

journal_title：BMC biology

authors： Sannino S,Brodsky JL

更新日期：2017-11-16 00:00:00

abstract：BACKGROUND:Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living cells. Recently, fluorescence resonance energy transfer (FRET) sensors...

journal_title：BMC biology

authors： Adjobo-Hermans MJ,Goedhart J,van Weeren L,Nijmeijer S,Manders EM,Offermanns S,Gadella TW Jr

更新日期：2011-05-27 00:00:00

abstract：BACKGROUND:The processes by which eggs develop in the insect ovary are well characterized. Despite a large number of Drosophila mutants that cannot lay eggs, the way that the egg is moved along the reproductive tract from ovary to uterus is less well understood. We remedy this with an integrative study on the reproduct...

journal_title：BMC biology

authors： Middleton CA,Nongthomba U,Parry K,Sweeney ST,Sparrow JC,Elliott CJ

更新日期：2006-06-12 00:00:00

abstract：BACKGROUND:The red algae (Rhodophyta) diverged from the green algae and plants (Viridiplantae) over one billion years ago within the kingdom Archaeplastida. These photosynthetic lineages provide an ideal model to study plastid genome reduction in deep time. To this end, we assembled a large dataset of the plastid genom...

journal_title：BMC biology

authors： Lee J,Cho CH,Park SI,Choi JW,Song HS,West JA,Bhattacharya D,Yoon HS

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...

journal_title：BMC biology

authors： Beckmann A,Xiao S,Müller JP,Mercadante D,Nüchter T,Kröger N,Langhojer F,Petrich W,Holstein TW,Benoit M,Gräter F,Özbek S

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors. RES...

journal_title：BMC biology

authors： Lammirato A,Patsch K,Feiereisen F,Maly K,Nofziger C,Paulmichl M,Hackl H,Trajanoski Z,Valovka T,Huber LA,Vietor I

更新日期：2016-10-25 00:00:00

abstract：BACKGROUND:The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant ...

journal_title：BMC biology

authors： Boursereau R,Abou-Samra M,Lecompte S,Noel L,Brichard SM

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal muscles of patients ...

journal_title：BMC biology

authors： Strah N,Romano G,Introna C,Klima R,Marzullo M,Ciapponi L,Megighian A,Nizzardo M,Feiguin F

更新日期：2020-03-26 00:00:00

abstract：:The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor--the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in v...

journal_title：BMC biology

authors： Gordon-Keylock S,Medvinsky A

更新日期：2011-12-28 00:00:00

abstract：BACKGROUND:Seed plants are composed of angiosperms and gymnosperms, which diverged from each other around 300 million years ago. While much light has been shed on the mechanisms and rate of genome evolution in flowering plants, such knowledge remains conspicuously meagre for the gymnosperms. Conifers are key representa...

journal_title：BMC biology

authors： Pavy N,Pelgas B,Laroche J,Rigault P,Isabel N,Bousquet J

更新日期：2012-10-26 00:00:00

abstract：BACKGROUND:Conditional gene knockout (cKO) mediated by the Cre/LoxP system is indispensable for exploring gene functions in mice. However, a major limitation of this method is that gene KO is not reversible. A number of methods have been developed to overcome this, but each method has its own limitations. RESULTS:We d...

journal_title：BMC biology

authors： Chaiyachati BH,Kaundal RK,Zhao J,Wu J,Flavell R,Chi T

更新日期：2012-11-30 00:00:00

abstract：BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...

journal_title：BMC biology

authors： Abuin L,Prieto-Godino LL,Pan H,Gutierrez C,Huang L,Jin R,Benton R

更新日期：2019-04-17 00:00:00

abstract：:Current interest in proteasome inhibitors for cancer therapy has stimulated considerable research efforts to identify the molecular pathway to their cytotoxicity with a view to identifying the mechanisms of sensitivity and resistance as well as informing the development of new drugs. Zhao and Vuori describe this month...

journal_title：BMC biology

authors： Chauhan D,Anderson KC

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:Sec8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function, including neurite outgrowth, calcium-dependent neurotransmitter secretion, trafficking of ionotropic glutamate receptors and regulation of neuronal microtubule ass...

journal_title：BMC biology

authors： Liebl FL,Chen K,Karr J,Sheng Q,Featherstone DE

更新日期：2005-12-13 00:00:00

abstract：BACKGROUND:Rickettsia are intracellular symbionts of eukaryotes that are best known for infecting and causing serious diseases in humans and other mammals. All known vertebrate-associated Rickettsia are vectored by arthropods as part of their life-cycle, and many other Rickettsia are found exclusively in arthropods wit...

journal_title：BMC biology

authors： Weinert LA,Werren JH,Aebi A,Stone GN,Jiggins FM

更新日期：2009-02-02 00:00:00

abstract：BACKGROUND:Nucleostemin is a nucleolus residing GTPase that is considered to be an important cancer stem/progenitor cell marker protein due to its high expression levels in breast cancer stem cells and its role in tumor-initiation of human mammary tumor cells. It has been proposed that nucleostemin may represent a valu...

journal_title：BMC biology

authors： Tin AS,Park AH,Sundar SN,Firestone GL

更新日期：2014-09-12 00:00:00

abstract：:CRISPR-Cas systems, the purveyors of adaptive immunity in archaea and bacteria and sources of the new generation of genome engineering tools, have been studied in exquisite molecular detail. However, when it comes to biological functions, ecology, and evolution of CRISPR-Cas, many more intriguing questions remain than...

journal_title：BMC biology

authors： Koonin EV

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial respiratory chain (MRC). The mechanisms of the latter effects are unclear. The aim of this study was to determine the mechanisms by wh...

journal_title：BMC biology

authors： García-Ruiz I,Solís-Muñoz P,Fernández-Moreira D,Muñoz-Yagüe T,Solís-Herruzo JA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (AC...

journal_title：BMC biology

authors： Kloehn J,Oppenheim RD,Siddiqui G,De Bock PJ,Kumar Dogga S,Coute Y,Hakimi MA,Creek DJ,Soldati-Favre D

更新日期：2020-06-16 00:00:00

abstract：:A common symbiont of insects, the bacterium Wolbachia has been implicated in phenomena as diverse as sex determination, pathogen defence and speciation and is being used in public health programs to prevent mosquitoes transmitting disease. Despite decades of research, we know remarkably little about how it exerts its ...

journal_title：BMC biology

authors： Jiggins FM

更新日期：2016-10-19 00:00:00

abstract：BACKGROUND:Antibiotic resistance is rendering common bacterial infections untreatable. Wildlife can incorporate and disperse antibiotic-resistant bacteria in the environment, such as water systems, which in turn serve as reservoirs of resistance genes for human pathogens. Anthropogenic activity may contribute to the sp...

journal_title：BMC biology

authors： Marcelino VR,Wille M,Hurt AC,González-Acuña D,Klaassen M,Schlub TE,Eden JS,Shi M,Iredell JR,Sorrell TC,Holmes EC

更新日期：2019-04-08 00:00:00