Abstract:
:Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection. Here, we explore the roles of mitochondrial autophagy (mitophagy) and the mitochondrial unfolded protein response (UPR(mt)) in the response to mitochondrial dysfunction, focusing in particular on recent evidence on the role of mitochondrial import efficiency in the regulation of these stress pathways and how they may interact to protect the mitochondrial pool while initiating an innate immune response to protect against bacterial pathogens.
journal_name
BMC Bioljournal_title
BMC biologyauthors
Pellegrino MW,Haynes CMdoi
10.1186/s12915-015-0129-1subject
Has Abstractpub_date
2015-04-03 00:00:00pages
22issn
1741-7007pii
s12915-015-0129-1journal_volume
13pub_type
杂志文章,评审相关文献
BMC BIOLOGY文献大全abstract::The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments in HIV modeling, emphasizing quantitative findings about HIV biology uncovered by studying acute infection, th...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/1741-7007-11-96
更新日期:2013-09-03 00:00:00
abstract::The expansion of genome sequencing projects has produced accumulating evidence for lateral transfer of genes between prokaryotic and eukaryotic genomes. However, it remains controversial whether these genes are of functional importance in their recipient host. Nikoh and Nakabachi, in a recent paper in BMC Biology, tak...
journal_title:BMC biology
pub_type: 评论,杂志文章
doi:10.1186/1741-7007-7-20
更新日期:2009-05-05 00:00:00
abstract:BACKGROUND:Base editors are a class of genome editing tools with the ability to efficiently induce point mutations in genomic DNA, without inducing double-strand breaks or relying on homology-direct repair as in other such technologies. Recently, adenine base editors (ABEs) have been developed to mediate the conversion...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0609-1
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes. Inactivating single oncogenes, such as c-Myc, can reverse even advanced tumours. Intrigui...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-2-26
更新日期:2004-12-21 00:00:00
abstract:BACKGROUND:Vertebrates are characterized by possession of hypobranchial muscles (HBMs). Cyclostomes, or modern jawless vertebrates, possess a rudimentary and superficial HBM lateral to the pharynx, whereas the HBM in jawed vertebrates is internalized and anteroposteriorly specified. Precursor cells of the HBM, marked b...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00851-y
更新日期:2020-09-09 00:00:00
abstract:BACKGROUND:Many Caenorhabditis elegans mutations increase longevity and much evidence suggests that they do so at least partly via changes in metabolism. However, up until now there has been no systematic investigation of how the metabolic networks of long-lived mutants differ from those of normal worms. Metabolomic te...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-14
更新日期:2010-02-10 00:00:00
abstract:BACKGROUND:Archaeological studies have revealed a series of cultural changes around the Last Glacial Maximum in East Asia; whether these changes left any signatures in the gene pool of East Asians remains poorly indicated. To achieve deeper insights into the demographic history of modern humans in East Asia around the ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-9-2
更新日期:2011-01-10 00:00:00
abstract::A common symbiont of insects, the bacterium Wolbachia has been implicated in phenomena as diverse as sex determination, pathogen defence and speciation and is being used in public health programs to prevent mosquitoes transmitting disease. Despite decades of research, we know remarkably little about how it exerts its ...
journal_title:BMC biology
pub_type: 社论
doi:10.1186/s12915-016-0312-z
更新日期:2016-10-19 00:00:00
abstract:BACKGROUND:Methods for assigning strains to bacterial species are cumbersome and no longer fit for purpose. The concatenated sequences of multiple house-keeping genes have been shown to be able to define and circumscribe bacterial species as sequence clusters. The advantage of this approach (multilocus sequence analysi...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-7-3
更新日期:2009-01-26 00:00:00
abstract:BACKGROUND:Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale. RESULTS:We depleted the intestinal microbiota of hypercholesterolemic female Apoe-...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0715-8
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Complex multicellularity requires elaborate developmental mechanisms, often based on the versatility of heterodimeric transcription factor (TF) interactions. Homeobox TFs in the TALE superclass are deeply embedded in the gene regulatory networks that orchestrate embryogenesis. Knotted-like homeobox (KNOX) TF...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-018-0605-5
更新日期:2018-11-05 00:00:00
abstract::There are many reasons to be interested in stem cells, one of the most prominent being their potential use in finding better drugs to treat human disease. This article focuses on how this may be implemented. Recent advances in the production of reprogrammed adult cells and their regulated differentiation to disease-re...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/1741-7007-9-42
更新日期:2011-06-07 00:00:00
abstract:BACKGROUND:Insects helped pioneer, and persist as model organisms for, the study of specific aspects of immunity. Although they lack an adaptive immune system, insects possess an innate immune system that recognizes and destroys intruding microorganisms. Its operation under natural conditions has not been well studied,...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-5-56
更新日期:2007-12-21 00:00:00
abstract:BACKGROUND:The discharge of the Cnidarian stinging organelle, the nematocyst, is one of the fastest processes in biology and involves volume changes of the highly pressurised (150 bar) capsule of up to 50%. Hitherto, the molecular basis for the unusual biomechanical properties of nematocysts has been elusive, as their ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-014-0113-1
更新日期:2015-01-16 00:00:00
abstract:BACKGROUND:Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial respiratory chain (MRC). The mechanisms of the latter effects are unclear. The aim of this study was to determine the mechanisms by wh...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-11-88
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Phylostratigraphy is a method used to correlate the evolutionary origin of founder genes (that is, functional founder protein domains) of gene families with particular macroevolutionary transitions. It is based on a model of genome evolution that suggests that the origin of complex phenotypic innovations wil...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-66
更新日期:2010-05-21 00:00:00
abstract::In this experiment, the authors were interested in testing the effect of a small molecule inhibitor on the ratio of males and females in the offspring of their model Dipteran species. The authors report that in a wild-type population, ~50 % of offspring are male. They then test the effect of treating females with the ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0275-0
更新日期:2016-06-23 00:00:00
abstract:BACKGROUND:Ionotropic receptors (IRs) are a large, divergent subfamily of ionotropic glutamate receptors (iGluRs) that are expressed in diverse peripheral sensory neurons and function in olfaction, taste, hygrosensation and thermosensation. Analogous to the cell biological properties of their synaptic iGluR ancestors, ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0651-7
更新日期:2019-04-17 00:00:00
abstract::The five most pervasive anthropogenic threats to biodiversity are over-exploitation, habitat changes, climate change, invasive species, and pollution. Since all of these threats can affect intraspecific biodiversity-including genetic variation within populations-humans have the potential to induce contemporary microev...
journal_title:BMC biology
pub_type: 杂志文章,评审
doi:10.1186/s12915-017-0476-1
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral state. Ye...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0176-7
更新日期:2015-08-25 00:00:00
abstract:BACKGROUND:mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS:As a proof of principle, we show in both cell lines and primary cell cultu...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-020-00790-8
更新日期:2020-07-03 00:00:00
abstract:BACKGROUND:Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mi...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0221-6
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:Invariant natural killer T (iNKT) cells differ from other T cells by their hyperactive effector T-cell status, in addition to the expression of NK lineage receptors and semi-invariant T-cell receptors. It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peri...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-8-142
更新日期:2010-11-30 00:00:00
abstract::The majority of convincingly documented cases of hybridization in angiosperms has involved genetic introgression between the parental species or formation of a hybrid species with increased ploidy; however, homoploid (diploid) hybridization may be just as common. Recent studies, including one in BMC Evolutionary Biolo...
journal_title:BMC biology
pub_type: 社论
doi:10.1186/1741-7007-8-45
更新日期:2010-04-21 00:00:00
abstract:BACKGROUND:Increasing evidence suggests that influenza reassortment not only contributes to the emergence of new human pandemics but also plays an important role in seasonal influenza epidemics, disease severity, evolution, and vaccine efficacy. We studied this process within 2091 H3N2 full genomes utilizing a combinat...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0337-3
更新日期:2016-12-29 00:00:00
abstract:BACKGROUND:Wolbachia are obligate endosymbiotic bacteria maternally transmitted through the egg cytoplasm that are responsible for several reproductive disorders in their insect hosts, such as cytoplasmic incompatibility (CI) in infected mosquitoes. Species in the Culex pipiens complex display an unusually high number ...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-5-39
更新日期:2007-09-20 00:00:00
abstract:BACKGROUND:How tissue and organ sizes are specified is one of the great unsolved mysteries in biology. Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. RESULTS:By exploring the possible effects of v...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-015-0122-8
更新日期:2015-02-19 00:00:00
abstract:BACKGROUND:TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors. RES...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-016-0318-6
更新日期:2016-10-25 00:00:00
abstract:BACKGROUND:Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living cells. Recently, fluorescence resonance energy transfer (FRET) sensors...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/1741-7007-9-32
更新日期:2011-05-27 00:00:00
abstract:BACKGROUND:Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon h...
journal_title:BMC biology
pub_type: 杂志文章
doi:10.1186/s12915-019-0633-9
更新日期:2019-02-22 00:00:00