Depressive symptoms and mortality in patients after kidney transplantation: a prospective prevalent cohort study.

Abstract:

OBJECTIVE:To analyze in a prospective cohort study if depressive symptoms are an independent predictor of mortality in kidney transplant recipients. METHODS:Data from 840 transplanted patients followed at a single outpatient transplant center were analyzed. Sociodemographic parameters and clinical data were collected at enrollment (between August 2002 and February 2003). Participants completed the Center for Epidemiologic Studies-Depression (CES-D) scale. Depression was defined as CES-D score of > or = 18. Data on 5-year outcomes (death censored graft loss or mortality) were collected. RESULTS:The prevalence of depression was 22%. Mortality was higher (21% versus 13%; p = .004) in patients with versus without depression. In a multivariate Cox proportional hazard model, both the baseline CES-D score (hazard ratio(for each 1-point increase) = 1.02; 95% confidence interval, 1.00-1.04) and the presence of depression at baseline (hazard ratio(presence) = 1.66; 95% confidence interval, 1.12-2.47) were significantly associated with mortality. The baseline CES-D score also significantly predicted death censored graft loss (hazard ratio(for each 1-point increase) = 1.03; 95% confidence interval, 1.01-1.05). CONCLUSION:Depressive symptoms are an independent predictor of mortality in kidney transplanted patients.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Novak M,Molnar MZ,Szeifert L,Kovacs AZ,Vamos EP,Zoller R,Keszei A,Mucsi I

doi

10.1097/PSY.0b013e3181dbbb7d

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

527-34

issue

6

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3181dbbb7d

journal_volume

72

pub_type

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