Abstract:
OBJECTIVE:To examine whether the 1-year prevalence of major depressive disorder (MDD), generalized anxiety disorder (GAD), and their comorbidity were associated with subsequent all-cause and cardiovascular disease (CVD) mortality during 15 years in Vietnam veterans. METHODS:Participants (N = 4256) were from the Vietnam Experience Study. Service, sociodemographic, and health data were collected from service files, telephone interviews, and a medical examination. One-year prevalence of MDD and GAD was determined through a diagnostic interview schedule based on the Diagnostic and Statistical Manual of Mental Disorders (version IV) criteria. Mortality over the subsequent 15 years was gathered from US army records. RESULTS:MDD and GAD were positively and significantly associated with all-cause and CVD mortality. The relationships between MDD and GAD and CVD mortality were no longer significant after adjustment for sociodemograhics, health status at entry, health behaviors, and other risk markers. Income was the covariate with the strongest impact on this association. In analyses comparing comorbidity and GAD and MDD alone, with neither diagnosis, comorbidity proved to be the strongest predictor of both all-cause and CVD mortality. CONCLUSION:GAD and MDD predict all-cause mortality in a veteran population after adjusting for a range of covariates. However, those with both GAD and MDD were at greatest risk of subsequent death, and it would seem that these disorders may interact synergistically to affect mortality. Future research on mental disorders and health outcomes, as well as future clinical interventions, should pay more attention to comorbidity.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Phillips AC,Batty GD,Gale CR,Deary IJ,Osborn D,MacIntyre K,Carroll Ddoi
10.1097/PSY.0b013e31819e6706subject
Has Abstractpub_date
2009-05-01 00:00:00pages
395-403issue
4eissn
0033-3174issn
1534-7796pii
PSY.0b013e31819e6706journal_volume
71pub_type
杂志文章abstract::This paper examines the relation of two personality characteristics (dominance and anger) to hormones in normally aging men. The relation of the Jackson Personality Research Form E Dominance subscale and the Spielberger Anger Expression scale to serum levels of 17 endocrine variables, including testosterone (T) and di...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199107000-00003
更新日期:1991-07-01 00:00:00
abstract::Previous research has suggested that patients with amyotrophic lateral sclerosis (ALS) demonstrate similar psychological characteristics that distinguish them from the medically ill populations, and that these findings may bear etiologic and prognostic importance. In this report, a larger sample was studied and the pr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197709000-00003
更新日期:1977-09-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine associations among race, the accumulation of multiple forms of discriminatory experiences (i.e., "pervasive discrimination"), and allostatic load (AL) in African Americans and whites in midlife. METHODS:Using data collected in 2004 to 2006 from 226 African American and 978 white a...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000788
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:While depression has been found to predict mortality in acute myocardial infarction, results from many other groups of medical patients are inconclusive. It is, therefore, unclear whether depression also predicts mortality in the typical mixed patient populations treated on medical hospital wards and whether ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199809000-00011
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Depression and anxiety have been inconsistently associated with diabetes. Sex differences in the biological and behavioral correlates of these forms of distress could partially explain these inconsistencies. We investigated sex-specific associations between depression/anxiety symptoms and diabetes in two sep...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000169
更新日期:2015-05-01 00:00:00
abstract::In this industrial-based study we compared the blood pressure (BP)-lowering effectiveness of relaxation, a beta blocker, and the combined use of these two treatments in 47 untreated, mildly hypertensive blue collar steel workers. Using a randomized two by two factorial design, patients received either nadolol or place...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-198909000-00004
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:Depression has been associated with increased risk of heart failure (HF). Because anxiety is highly comorbid with depression, we sought to establish if anxiety, depression, or their co-occurrence is associated with incident HF. METHODS:A retrospective cohort (N = 236,079) including Veteran's Administration p...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000027
更新日期:2014-02-01 00:00:00
abstract::Negative affectivity (NA) and repressive coping (REP) are coping styles characterized by a disposition to either experience or avoid distress. This study investigated the potential influence of NA and REP on self-reported distress and coronary-prone behavior among 178 male cardiac patients undergoing rehabilitation. B...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199109000-00005
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between hostility and biological risk factors for coronary heart disease (CHD) in a population of white European and South Asian men and women living in the United Kingdom. METHODS:This cross-sectional study involved a community-based sample of 1,757 healthy white and South Asian ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181fd944c
更新日期:2011-01-01 00:00:00
abstract::Sixty subjects classified as either Type A or Type B interacted in pairs by pressing buttons which transmitted messages through a television screen while the heart rate and digital blood volume pulse were computer-monitored. Partners could cooperate, compete, punish, reward, or withdraw on each interaction and could s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197902000-00002
更新日期:1979-02-01 00:00:00
abstract:OBJECTIVE:Fatigue is a common problem among cancer patients and survivors, yet the mechanisms underlying the occurrence and persistence of this symptom are not known. Activation of the immune system may evoke feelings of fatigue, which are mediated by proinflammatory cytokines. We examined whether fatigued breast cance...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200207000-00010
更新日期:2002-07-01 00:00:00
abstract::Fifty-eight normal adolescent Swedish boys, aged 16, provided two sets of blood samples for plasma testosterone assays as well as data on a number of personality inventories and rating scales assessing aggression, inpulsiveness, lack of frustration tolerance, extraversion, and anxiety. Physical variables such as puber...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198003000-00003
更新日期:1980-03-01 00:00:00
abstract:OBJECTIVE:Lactation has been associated with attenuated hormonal responses to exercise stress in humans. This study was designed to determine the effect of lactation on hypothalamic-pituitary-adrenal axis, autonomic nervous system, and anxiety responses to psychological stress. METHOD:The Trier Social Stress Test was ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200109000-00015
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To investigate the association of a range of temporally prior physical conditions with the subsequent first onset of suicidal ideation, plans, and attempts in large, general population, cross-national sample. The associations between physical conditions and suicidal behavior remain unclear due to sparse data ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181e3333d
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to test the hypothesis that higher childhood cognitive ability is associated with reduced risk of decline in physical capability in late midlife. METHODS:Participants were 1954 men and women from the Medical Research Council National Survey of Health and Development with complete dat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000482
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVES:Asthma is a chronic condition affecting 300 million people worldwide. Management involves adherence to pharmacological treatments such as corticosteroids and β-agonists, but residual symptoms persist. As asthma symptoms are exacerbated by stress, one possible adjunct to pharmacological treatment is expressiv...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0000000000000166
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:Agency has been conceptualized as a drive toward mastery, control, and effective self-management. Such an agentic approach to life and its challenges may be life-prolonging, a hypothesis not previously investigated. METHOD:In four studies, individual differences in agency were assessed in terms of the frequ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000337
更新日期:2016-09-01 00:00:00
abstract::Sixteen healthy women (20-32 years) not taking oral contraceptives were tested at three phases of their menstrual cycles (menses, preovulatory phase, and midluteal phase). Another 16 women taking oral contraceptives served as age-matched controls, and were tested during menses and during phases corresponding to the pr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199409000-00005
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:We examined the relationship between hostility and mononuclear leukocyte (MNL) beta-adrenergic receptor function in a sample of young healthy males. METHOD:Thirty subjects were selected for having scored above 20 (N = 11) and below 14 (N = 19) on the Cook-Medley Hostility (Ho) scale. MNL beta-adrenergic rece...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199709000-00004
更新日期:1997-09-01 00:00:00
abstract::Recent technologic advances have permitted the observation of rapid and significant increases in blood pressure (BP) during verbal communication. The magnitude of the increase in BP is influenced by rate of speech, audience size, status, affective content, environmental setting, and resting BP. The current study evalu...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198601000-00008
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:A previous study suggested that insulin metabolic variables play a role in the progression of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits. The present study sought to determine: 1) if young, individually caged WHHLs are insulin-resistant relative to New Zealand white (NZW) rabbits and ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000155674.95497.ab
更新日期:2005-03-01 00:00:00
abstract::Thirty normal-weight female bulimics were followed up 2-5 years following hospital admission using semistructured interviews and psychometric measures. Inasmuch as bulimia was only recently designated a distinct disorder, questions have emerged with regard to its clinical course and diagnostic validity. Results of thi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198701000-00004
更新日期:1987-01-01 00:00:00
abstract::The Monroe County Psychiatric Case Register and hospital records were used to investigate the incidence of anorexia nervosa in Monroe County, New York, during the periods 1960-1969 and 1979-1976 to determine whether the number of newly diagnosed cases has increased over time. The results support the general clinical i...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198011000-00003
更新日期:1980-11-01 00:00:00
abstract::The Rosenberg Self-Esteem Scale, Beck Depression Inventory, and Sullivan Diabetic Adjustment Scale were administered to 105 adolescent girls with diabetes. Results indicate that levels of self-esteem and depression highly correlate with the level of adjustment as assessed on the Diabetic Adjustment Scale (DAS). That i...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197903000-00006
更新日期:1979-03-01 00:00:00
abstract::The study consisted of 1101 Caucasian, male outpatients, who were screened for depression and hypertension in order to test the hypothesis that there is a unique relationship between these two illnesses. Depression was assessed by the Zung Self-Rating Depression Scale (SDS) while diastolic blood pressure (BP) was acce...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197703000-00008
更新日期:1977-03-01 00:00:00
abstract::Denial may be adaptive during hospitalization for acute coronary disease. We studied the impact of denial in 48 patients referred to a tertiary care center for treatment of unstable angina. Using the Hackett-Cassem Denial Scale, we divided the group into 25 high deniers and 23 low deniers. The two groups were comparab...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198901000-00003
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To examine the role of self-efficacy and depression as potential pathways from physical activity to fatigue in two study samples: breast cancer survivors (BCS) (n = 192) and individuals with multiple sclerosis (MS) (n = 292). METHODS:We hypothesized that physical activity would be associated indirectly with ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181c68157
更新日期:2010-01-01 00:00:00
abstract::The study of depression in cancer patients has been hampered by difficulty in establishing diagnostic criteria, since neurovegetative signs and symptoms may be attributable either to depression or physical illness. Confusion has also arisen in defining the boundary between "normal" grieving with illness, and "abnormal...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198405000-00002
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:Placebo effects relieve various somatic symptoms, but it is unclear how they can be enhanced to maximize positive treatment outcomes. Oxytocin administration may potentially enhance placebo effects, but few studies have been performed, and they have had conflicting findings. The study aim was to investigate t...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0000000000000571
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To assess whether work characteristics and social support are predictors of physical, psychological, and social functioning. METHOD:Work characteristics (Karasek and Siegrist models) and social support at baseline were used to predict health functioning measured by the SF-36 General Health Survey 5 years lat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199805000-00004
更新日期:1998-05-01 00:00:00