Abstract：
INTRODUCTION:The influence of antipsychotic medication on brain alterations in proton magnetic resonance spectroscopy (1H MRS) in schizophrenia can be the explanation of many discrepancies observed in the previous papers. AIM:The aim of this study was the evaluation of antipsychotic medication effect on the metabolite levels in the brain of schizophrenic patients based on 1H MRS examination. METHODS:The group of 32 patients with a diagnosis of schizophrenia according to DSM-IV and 26 healthy controls were included into the study. The patients were examined twice--once after the period of at least 7 days without neuroleptics (baseline) and for the second time at least 4 weeks after stable doses ofneuroleptics (follow-up). 21 patients were receiving risperidone and 11--olanzapine. Proton resonance spectroscopy was performed on a 1.5 MR scanner. Each volume element (voxel) was localised in the left frontal lobe, in the left temporal lobe and in the left thalamus. Metabolite ratios: N-acetylaspartate (NAA) to creatine (Cr) and unsupressed water signal were analysed. Results. We found the significant increase of the NAA/Cr level in the thalamus in the group of patients treated with risperidone, we didn't observe similar changes in the olanzapine group. CONCLUSIONS:Our results confirm that the neuroleptic drugs, especially atypicals, modify brain metabolism measured by 1H MRS. The pattern of the changes suggest a possible neuroprotective influence of the antipsychototic treatment in schizophrenic patients. The small group of the olanzapine treated patients doses not allow to make any conclusions regarding this type of medication.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Szulc A,Galińiska B,Tarasów E,Dzienis W,Kubas B,Konarzewska B,Waszkiewicz N,Popławska Rsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
415-26issue
3eissn
0033-2674issn
2391-5854journal_volume
44pub_type
杂志文章abstract：:Nowadays, it is becoming increasingly difficult to clearly classify the issues associated with the phenomenon of gender dysphoria due to the fact that one identifies oneself in the context of increasingly fluid categories of gender identity-- an intrinsic sense of being a woman or a man. The authors present a woman wh...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:In this paper we review previous research, suggesting a link between depressive symptoms and poor prognosis in cancer patients. The possibility, to identify an association between depressed mood and poorer outcomes and survival in haematological malignancies seems to be very interesting. We shortly describe acute leuk...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
abstract：:The purpose of this investigation was to analyze several personality dimensions including several psychopathological symptoms of women experiencing infertility. 70 females experiencing infertility and 50 healthy women were examined using psychological methods: MMPI and the State-Trait Anxiety Inventory by Spielberger,...
journal_title：Psychiatria polska
pub_type： 杂志文章
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更新日期：1995-07-01 00:00:00
abstract：:Schizophrenia is an illness with a large variety of symptoms, significant variability of the individual course, and still not fully explained etiology. It is suggested that genetic, infectious and immunological factors may be involved, and neurodevelopmental, neurodegenerative and neurotransmitter hypotheses have been...
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pub_type： 杂志文章,评审
doi：10.12740/PP/114952
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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更新日期：1994-05-01 00:00:00
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journal_title：Psychiatria polska
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doi：
更新日期：2002-09-01 00:00:00
abstract：AIM:To analyse psychometric value of the Polish version of the GEOPTE Scale, a self-rating scale measuring social cognition among persons suffering from schizophrenic psychoses. METHOD:Fifty patients with diagnosis of schizophrenia according to ICD-10 criteria were assessed by the scale under study. Analysis of its us...
journal_title：Psychiatria polska
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doi：
更新日期：2010-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
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journal_title：Psychiatria polska
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doi：
更新日期：2000-01-01 00:00:00
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journal_title：Psychiatria polska
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更新日期：2000-03-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
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journal_title：Psychiatria polska
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更新日期：1999-03-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
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更新日期：2004-09-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
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更新日期：1999-07-01 00:00:00
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journal_title：Psychiatria polska
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doi：
更新日期：2005-03-01 00:00:00
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journal_title：Psychiatria polska
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doi：
更新日期：1989-07-01 00:00:00
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journal_title：Psychiatria polska
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doi：
更新日期：2005-01-01 00:00:00
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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更新日期：2011-05-01 00:00:00
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journal_title：Psychiatria polska
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更新日期：2012-01-01 00:00:00
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journal_title：Psychiatria polska
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更新日期：1993-01-01 00:00:00
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