Abstract:
OBJECTIVE:To compare the diagnostic performance of models based on a combination of contrast-enhanced (CE) magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) or time-intensity curves (TIC) in diagnosing malignancies of breast lesions. METHODS:A double-blind retrospective study was conducted in 328 patients (254 for training and the following 74 for validation) who underwent dynamic contrast-enhanced MRI (DCE-MRI) of the breast with pathological results. Two score models, the DWI model (apparent diffusion coefficient (ADC) + morphology + enhanced information) and the TIC model (TIC + morphology + enhanced information), were established with binary logistic regression for mass and non-mass enhancements (NMEs) in the training set. The sensitivity, specificity, and area under the curve (AUC) were compared between the two models (DWI model vs. TIC model); p < 0.05 was considered as statistically different. External validation was used. RESULTS:In the training set, the sensitivities, specificities, and AUCs of the DWI/TIC model were 95.2%/95.8%, 70.8%/47.9%, and 0.932/0.891 for masses, and 94.2%/90.4%, 47.4%/47.4%, and 0.798 (95% CI, 0.686-0.884)/0.802 (95% CI, 0.691-0.887) for NMEs, respectively. The AUC of the DWI model was significantly higher than that of the TIC model (p < 0.05) for masses. In the validation set, the AUCs of the DWI/TIC model were 0.896/0.861 for masses (p < 0.05) and 0.936/0.836 for NMEs (p > 0.05). CONCLUSIONS:Combined with CE MRI, the DWI model was superior or equal to the TIC model in differentiating benign and malignant breast lesions. KEY POINTS:• Diffusion magnetic resonance imaging played an important role in the diagnosis of breast neoplasms. • On the basis of contrast-enhanced MRI, the DWI model had significantly higher diagnostic ability than the TIC model in distinguishing benign and malignant masses. • It would be reasonable to replace the time-consuming TIC with DWI for less scan time and similar diagnostic efficiency.
journal_name
Eur Radioljournal_title
European radiologyauthors
Yang X,Dong M,Li S,Chai R,Zhang Z,Li N,Zhang Ldoi
10.1007/s00330-020-06883-wsubject
Has Abstractpub_date
2020-09-01 00:00:00pages
4795-4805issue
9eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-06883-wjournal_volume
30pub_type
杂志文章abstract:OBJECTIVES:To evaluate the safety and efficacy of iopentol 350 mg I/ml (Imagopaque/Ivépaque, Nycomed Imaging AS, Oslo, Norway), a monomeric non-ionic contrast medium for computed tomography, in a large population. To identify predictive factors for patient safety. MATERIALS AND METHODS:One thousand eight hundred and t...
journal_title:European radiology
pub_type: 临床试验,杂志文章,多中心研究
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abstract::To assess both sensitivity and specificity of digital chest radiography alone and in conjunction with dual-exposure dual-energy chest radiography for the detection and classification of pulmonary nodules. One hundred patients with a total of 149 lung nodules (3-45 mm; median, 11 mm) confirmed by CT were included in th...
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 临床试验,杂志文章
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