Abstract:
OBJECTIVE:To assess the value of time-intensity curves obtained after sulphur hefluoride-filled microbubble contrast agent injection to discriminate responders from non-responders among patients with Crohn's disease (CD). METHODS:Forty-three patients (29 male and 14 female; mean age ± SD, 48.5 ± 17.17 years) with initial diagnosis of active CD were recruited. In each patient, the therapeutic outcome was assessed after 12 weeks from the beginning of pharmacologic treatment. The terminal ileal loop was scanned after sulphur hexafluoride-filled microbubble injection, and the digital cine-clip registered during the first-pass dynamic enhancement was quantified in gray-scale levels. The percentage of maximal enhancement, time to peak enhancement, and area under the time-intensity curve in responders vs. non-responders were compared by Mann-Whitney U non-parametric test. RESULTS:Responders (n = 25 patients) vs. non-responders (n = 18) differed in the area under the time-intensity curve (621.58 ± 374.53 vs. 1,199.64 ± 386.39 P < 0.05), while they did not differ in percentage of maximal enhancement (41.26 ± 15.22 vs. 43.17 ± 4.41, P = 0.25) and time to peak enhancement (11.31 ± 3.06 vs. 10.12 ± 3.47, P = 0.15). CONCLUSIONS:The area under the time-intensity curve obtained after microbubble injection was the only parameter to discriminate responders from non-responders among patients with CD during pharmacologic treatment. KEY POINTS:• Dynamic ultrasound using microbubble contrast agents can help assess inflammatory bowel disease • Time-intensity curves can assess therapeutic outcome in Crohn's disease (CD) • The area under the time-intensity curve differentiates responders from non-responders during pharmacological treatment.
journal_name
Eur Radioljournal_title
European radiologyauthors
Quaia E,Cabibbo B,De Paoli L,Toscano W,Poillucci G,Cova MAdoi
10.1007/s00330-012-2754-1subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1650-9issue
6eissn
0938-7994issn
1432-1084journal_volume
23pub_type
杂志文章abstract:OBJECTIVES:To retrospectively determine incidence of early arterial blood flow stasis and its influencing factors during resin-based radioembolization (RE) of liver tumours. METHODS:Data of patients undergoing resin-based RE from 06/2006-12/2013 were reviewed. Second RE procedures of the same liver lobe were excluded....
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4076-6
更新日期:2016-08-01 00:00:00
abstract::Magnetic resonance (MR) arthrography has gained increasing popularity as a diagnostic tool in the assessment of intra-articular derangements. Its role has been studied extensively in the shoulder, but it also has been explored in the hip, elbow, knee, wrist and ankle. This article reviews the current role of direct MR...
journal_title:European radiology
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journal_title:European radiology
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doi:10.1007/s00330-017-5070-y
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abstract::Severe thoracic sarcoidosis includes manifestations with significant clinical and functional impairment and a risk of mortality. Severe thoracic sarcoidosis can take on various clinical presentations and is associated with increased morbidity. The purpose of this article was to describe the CT findings in severe thora...
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doi:10.1007/s00330-004-2480-4
更新日期:2005-01-01 00:00:00
abstract::Cavernous angiomas are vascular malformations composed of slowly perfused, sinusoidal vessels which can be located in any part of the central nervous system. Whereas diagnosis is mostly straightforward in typical cases, some lesions may present in unusual locations or with unusual imaging characteristics. Because of t...
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更新日期:2006-10-01 00:00:00
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更新日期:2004-06-01 00:00:00
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doi:10.1007/s00330-004-2380-7
更新日期:2004-11-01 00:00:00
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doi:10.1007/s00330-004-2452-8
更新日期:2005-02-01 00:00:00
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更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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doi:10.1007/s003300050102
更新日期:1997-01-01 00:00:00
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更新日期:2005-09-01 00:00:00
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更新日期:2013-09-01 00:00:00
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更新日期:2010-10-01 00:00:00
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