当前位置： SCI文献检索 > EUROPEAN RADIOLOGY期刊下所有文献 > Evaluation of iopentol (Imagopaque 350) in CT enhancement. A multi-centre monitoring trial assessing adverse events and diagnostic information--results from 1,823 patients in France.

Evaluation of iopentol (Imagopaque 350) in CT enhancement. A multi-centre monitoring trial assessing adverse events and diagnostic information--results from 1,823 patients in France.

Abstract：

OBJECTIVES:To evaluate the safety and efficacy of iopentol 350 mg I/ml (Imagopaque/Ivépaque, Nycomed Imaging AS, Oslo, Norway), a monomeric non-ionic contrast medium for computed tomography, in a large population. To identify predictive factors for patient safety. MATERIALS AND METHODS:One thousand eight hundred and twenty-three (1,823) patients from 48 centres in France were included during a 5-month period. Safety was evaluated by registering adverse events (AEs) reported by the patients, and data were analysed using a multiple factor model. RESULTS:Only 2.6% of the patients experienced AEs other than discomfort. There were no serious AEs. Overall, AEs were more frequent in patients under 50 years of age, in women, and in patients who received contrast medium as a single bolus. Contrast enhancement was considered adequate or better in 98.9% of the patients. A large variation in discomfort (local warmth/chill or pain) frequency was seen between centres, ranging from 0% to 81%. This result implies that factors other than the CM influence the incidence of discomfort. CONCLUSIONS:This first study in a large population shows that iopentol 350 mg I/ml is well tolerated and provides CT images of excellent, good or adequate quality in the vast majority of patients. Age, sex and injection procedure were shown to be independent predictors in the AE survey.

journal_name

Eur Radiol

journal_title

European radiology

authors

Oxaal M,Lambrechts M,Bunouf P,Menuet JF

doi

10.1007/pl00006874

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

S109-14

eissn

0938-7994

issn

1432-1084

journal_volume

7 Suppl 4

pub_type

临床试验,杂志文章,多中心研究

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