Abstract:
OBJECTIVES:To determine the integrative value of contrast-enhanced computed tomography (CECT), transcriptomics data and clinicopathological data for predicting the survival of bladder urothelial carcinoma (BLCA) patients. METHODS:RNA sequencing data, radiomics features and clinical parameters of 62 BLCA patients were included in the study. Then, prognostic signatures based on radiomics features and gene expression profile were constructed by using least absolute shrinkage and selection operator (LASSO) Cox analysis. A multi-omics nomogram was developed by integrating radiomics, transcriptomics and clinicopathological data. More importantly, radiomics risk score-related genes were identified via weighted correlation network analysis and submitted to functional enrichment analysis. RESULTS:The radiomics and transcriptomics signatures significantly stratified BLCA patients into high- and low-risk groups in terms of the progression-free interval (PFI). The two risk models remained independent prognostic factors in multivariate analyses after adjusting for clinical parameters. A nomogram was developed and showed an excellent predictive ability for the PFI in BLCA patients. Functional enrichment analysis suggested that the radiomics signature we developed could reflect the angiogenesis status of BLCA patients. CONCLUSIONS:The integrative nomogram incorporated CECT radiomics, transcriptomics and clinical features improved the PFI prediction in BLCA patients and is a feasible and practical reference for oncological precision medicine. KEY POINTS:• Our radiomics and transcriptomics models are proved robust for survival prediction in bladder urothelial carcinoma patients. • A multi-omics nomogram model which integrates radiomics, transcriptomics and clinical features for prediction of progression-free interval in bladder urothelial carcinoma is established. • Molecular functional enrichment analysis is used to reveal the potential molecular function of radiomics signature.
journal_name
Eur Radioljournal_title
European radiologyauthors
Lin P,Wen DY,Chen L,Li X,Li SH,Yan HB,He RQ,Chen G,He Y,Yang Hdoi
10.1007/s00330-019-06371-wsubject
Has Abstractpub_date
2020-01-01 00:00:00pages
547-557issue
1eissn
0938-7994issn
1432-1084pii
10.1007/s00330-019-06371-wjournal_volume
30pub_type
杂志文章abstract::Two cases of agenesis of the horizontal segment of the left portal vein are reported. This very rare vascular anomaly probably corresponds to an embryological variation rather than to an obstruction of the left portal vein. In almost all cases liver ultrasonography is sufficient for identifying such vascular abnormali...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050057
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To compare image quality and radiation dose using Adaptive Statistical Iterative Reconstruction (ASiR) and Filtered Back Projection (FBP) in patients weighing ≥ 91 kg. METHODS:In this Institution Review Board-approved retrospective study, single-phase contrast-enhanced abdominopelvic CT examinations of 100 a...
journal_title:European radiology
pub_type: 杂志文章
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journal_title:European radiology
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journal_title:European radiology
pub_type: 杂志文章,多中心研究
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更新日期:2012-05-01 00:00:00
abstract::Because of its sensitivity and high tissue contrast, magnetic resonance imaging (MRI) is the technique of choice for structural imaging in epilepsy. In this review the effect of using optimised scanning protocols and the use of high field MR systems on detection sensitivity is discussed. Also, the clinical relevance o...
journal_title:European radiology
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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更新日期:1996-01-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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pub_type: 杂志文章,实务指引,评审
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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更新日期:2018-06-01 00:00:00