Abstract:
BACKGROUND AND PURPOSE:Outcome measurement fidelity within and between sites of multi-site, randomized, clinical trials is an essential element to meaningful trial outcomes. As important are the methods developed for randomized, clinical trials that can have practical utility for clinical practice. A standardized measurement method and rater training program were developed for the total Fugl-Meyer motor and sensory assessments; inter-rater reliability was used to test program effectiveness. METHODS:Fifteen individuals with hemiparetic stroke, 17 trained physical therapists across 5 regional clinical sites, and an expert rater participated in an inter-rater reliability study of the Fugl-Meyer motor (total, upper extremity, and lower extremity subscores) and sensory (total, light touch, and proprioception subscores) assessments. RESULTS:Intra-rater reliability for the expert rater was high for the motor and sensory scores (range, 0.95-1.0). Inter-rater agreement (intraclass correlation coefficient, 2, 1) between expert and therapist raters was high for the motor scores (total, 0.98; upper extremity, 0.99; lower extremity, 0.91) and sensory scores (total, 0.93; light touch, 0.87; proprioception, 0.96). CONCLUSIONS:Standardized measurement methods and training of therapist assessors for a multi-site, rehabilitation, randomized, clinical trial resulted in high inter-rater reliability for the Fugl-Meyer motor and sensory assessments. Poststroke sensorimotor impairment severity can be reliably assessed for clinical practice or rehabilitation research with these methods.
journal_name
Strokejournal_title
Strokeauthors
Sullivan KJ,Tilson JK,Cen SY,Rose DK,Hershberg J,Correa A,Gallichio J,McLeod M,Moore C,Wu SS,Duncan PWdoi
10.1161/STROKEAHA.110.592766subject
Has Abstractpub_date
2011-02-01 00:00:00pages
427-32issue
2eissn
0039-2499issn
1524-4628pii
STROKEAHA.110.592766journal_volume
42pub_type
杂志文章,多中心研究,随机对照试验相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Preischemic spontaneous locomotor activity was distinguished in this laboratory as a factor influencing outcome after 15 and 20 minutes of forebrain ischemia in gerbils. Histological investigations were carried out to analyze potential relations between postischemic survival and a reduction of ce...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.9.1862
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To investigate the incidence of retrograde flow from complex plaques (> or =4-mm-thick, ulcerated, or superimposed thrombi) of the descending aorta (DAo) and its potential role in embolic stroke. METHODS:Ninety-four consecutive acute stroke patients with aortic plaques > or =3-mm-thick in transe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.577775
更新日期:2010-06-01 00:00:00
abstract::Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow we...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.5.976
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Subarachnoid hemorrhage (SAH) is a relatively rare cause of stroke with a high rate of morbidity and mortality, primarily due to the occurrence of delayed vasospasm. To date, many therapies have been proposed to help prevent vasospasm, but very few have been proven effective. The initiation of st...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.107.508341
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke mortality is decreasing in Sweden, as is the case in other Western European countries. However, both decreases and increases have been reported in Sweden for persons younger than age 65 years. The aim of this study was to compare the incidence of stroke in Sweden between the periods 1989 a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000125866.78674.96
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hyperglycemia enhances the deleterious effect of global cerebral ischemia. One possible explanation is that increased anaerobic glycolysis leads to exaggeration of intracellular acidosis and increased postischemic edema. To examine the importance of this edema on postischemic cerebral perfusion d...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.8.1405
更新日期:1996-08-01 00:00:00
abstract::The nature of alpha-adrenergic receptors in human cerebral arteries was characterized, and alteration of these receptors after subarachnoid hemorrhage was examined using a radioligand binding assay. Norepinephrine content of control arteries was also analyzed and compared with that of arteries after subarachnoid hemor...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.1.80
更新日期:1988-01-01 00:00:00
abstract::Cerebral autoregulation can be duplicated in vitro using the large middle cerebral arteries from a calf. The limits of autoregulation were between 50 and 150 mm Hg. Excessively high pressures may lead to the appearance of the "sausage- or bead-string" response followed by forced dilation. These results suggest the exi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.5.640
更新日期:1981-09-01 00:00:00
abstract::Background and Purpose- We aimed to determine whether low-frequency electric field navigated repetitive transcranial magnetic stimulation to noninjured motor cortex versus sham repetitive transcranial magnetic stimulation avoiding motor cortex could improve arm motor function in hemiplegic stroke patients when combine...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.117.020607
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To investigate the efficacy of bone marrow mononuclear cell (BMMNC) treatment against ischemic white matter (WM) damage in a hypoperfused brain. METHODS:Mice were administered intravenous treatment of vehicle, spleen-derived marrow mononuclear cells (MNCs), or BMMNCs (5 × 10⁶ cells) obtained fro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.596379
更新日期:2010-12-01 00:00:00
abstract::Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agonist, bexarotene, i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027037
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institute of Neurological Disorders and Stroke-Canadian Stroke Network Vascular Cognitive Impairment Harmonization working group proposed a brief cognitive protocol for screening of vascular cognitive impairment. We investigated the validity, reliability, and feasibility of the Montr...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.007253
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Increased degradation of the extracellular matrix in the arterial wall by matrix metalloproteinases (MMPs) may be an important mechanism in the pathogenesis of intracranial aneurysms and subarachnoid hemorrhage (SAH). MMP-2 and MMP-9 have been suggested to be involved in matrix degradation preced...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020660
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to characterize the spatial and temporal evolution of human cerebral infarction. Using a novel method of quantitatively mapping the distribution of hypoxic viable tissue identified by 18F-fluoromisonidazole (18F-FMISO) PET relative to the final infarct, we determined its evolution and s...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.STR.0000094422.74023.FF
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chronic ocular ischemia is a rare form of ischemia of the eye in patients with carotid artery occlusion (CAO). The early and often asymptomatic stage of chronic ocular ischemia is referred to as venous stasis retinopathy (VSR). The aim of this study was to gain insight into the prevalence, cause,...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/hs0302.104619
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:In the United States, stroke mortality is higher in the south than in other regions. Hypertension is the main risk factor for stroke among older adults; however, few studies have examined group-specific regional and urbanization differences in hypertension prevalence. METHODS:Data from the Third National He...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.1.19
更新日期:2000-01-01 00:00:00
abstract::In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thromboembolic attacks among women 15-44 years of age, and 971 cases among men of the same age. Cerebral infarction accounted for 70% of cases and transient ischemic attacks (TIA) for the remaining 30%. By analysing this mate...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.4.670
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). METHODS:Patients with proximal middle cerebral artery occlusions included i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.673665
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The premotor cortex (PMC) (Brodmann 6) contributes uniquely to proximal upper and lower limb power and plays a role in the organization of motor behaviors. We assessed the degree to which PMC damage affected functional outcome. METHODS:We prospectively compared the functional outcome of patients...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.7.1380
更新日期:1999-07-01 00:00:00
abstract::U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. Increased frequency of the epsilon 4 allele has also been reported in patients with late-onset familial and sporadic Alzheimer's disease (AD). The aim of this study was to investigate the deg...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.5.743
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Urinary incontinence (UI) is a common and distressing problem after stroke. Although there is evidence of new, effective UI poststroke rehabilitation intervention, it is unknown whether occupational therapists (OTs)' and physical therapists (PTs)' actual practices reflect best practices. We sough...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486035
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Our investigation sought to determine whether neonatal brain ischemic vascular and metabolic effects were altered by repeated episodes of ischemia. METHODS:We studied twelve piglets using in vivo magnetic resonance spectroscopy to obtain multiple, simultaneous measurements of cerebral blood flow...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.3.380
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In animals, drugs that increase brain amine concentrations influence the rate and degree of recovery from cortical lesions. It is therefore conceivable that antidepressants may influence outcome after ischemic brain injury in humans. We evaluated the effects of the norepinephrine reuptake blocker...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.27.7.1211
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Three-dimensional pseudocontinuous arterial spin labeling with multiple postlabeling delays has been used to assess cerebral blood flow (CBF). We used this modality to estimate antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis. METHODS:Consecutive patients...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.011057
更新日期:2016-02-01 00:00:00
abstract:UNLABELLED:The pathophysiology of postischemic encephalopathy is complex, and includes tissue acidosis, edema, hypoperfusion, membrane dysfunction, impaired energy production, and possibly hypermetabolism. We tested the hypothesis that this multifactorial clinical problem must be approached with multifaceted therapy, w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.5.803
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Vascular effects of mental stress are only partially understood. Therefore, we studied effects of chronic stress and heart rate (HR) on endothelial function and cerebral ischemia. METHODS:129S6/SvEv mice were randomized to the I(f)-channel inhibitor ivabradine (10 mg/kg per day) or vehicle and u...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.598607
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroprotective effects of electric stimulation have been recently shown in ischemic stroke, but the underlying mechanisms remain poorly understood. METHODS:Adult Wistar rats weighing 200 to 250 g received occlusion of the right middle cerebral artery for 90 minutes. At 1 hour after reperfusion,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.563627
更新日期:2009-11-01 00:00:00
abstract::Exposure of Mongolian gerbils to a 100% oxygen atmosphere after 15 minutes of global brain ischemia resulted in a marked increase in the production of pentane, an in vivo product of lipid peroxidation. Much less pentane production occurred in animals subjected to global brain ischemia then exposed to an air atmosphere...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.2.426
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Numerous studies indicate that mild hypothermia provides substantial neuroprotection. However, current systems transfer insufficient heat to rapidly vary core temperature. We thus evaluated the safety and efficacy of endovascular cooling and rewarming for the induction and reversal of hypothermia...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000057461.56040.FE
更新日期:2003-03-01 00:00:00