Backbone assignment of the little finger domain of a Y-family DNA polymerase.

abstract：:Human heterogeneous nuclear ribonucleoprotein H (hnRNP H) regulates alternative splicing of HIV-1 Tat pre-mRNA. The structure of the first N-terminal domain (residues 1-104) of hnRNP H was solved and its binding to an exonic splicing silencer (pESS2) studied. For this, all backbone and 85% of side-chain resonance freq...

journal_title：Biomolecular NMR assignments

authors： Cabal S,van Heijenoort C,Guittet E

更新日期：2007-12-01 00:00:00

abstract：:PTPN5 is a protein tyrosine phosphatase that plays an integral role in regulating excitatory postsynaptic activity. The sequence-specific backbone assignments of the murine PTPN5 catalytic domain have been determined based on triple-resonance experiments using uniformly [(2)H,(13)C,(15)N]-labeled protein. ...

journal_title：Biomolecular NMR assignments

authors： Francis DM,Page R,Peti W

更新日期：2014-04-01 00:00:00

abstract：:X-linked inhibitor of apoptosis protein (XIAP), a leading member of the family of inhibitor of apoptosis (IAP) proteins, is considered as the most potent and versatile inhibitor of caspases and apoptosis. It has been reported that XIAP is frequently overexpressed in cancer and its expression level is implicated in con...

journal_title：Biomolecular NMR assignments

authors： Hui SK,Tse MK,Yang Y,Wong BC,Sze KH

更新日期：2010-04-01 00:00:00

abstract：:Repressor of primer (Rop, or ROM, RNA I modulator) is a 63 amino acid four-helix bundle protein that exists in solution as an anti-parallel homodimer. This protein has been extensively studied, including by X-ray crystallography, NMR, rational design, and combinatorial mutagenesis. Previous NMR experiments with wild-t...

journal_title：Biomolecular NMR assignments

authors： Bowles DP,Yuan C,Stephany KR,Lavinder JJ,Hansen AL,Magliery TJ

更新日期：2018-10-01 00:00:00

abstract：:Ebola viral infections have resulted in several deadly epidemics in recent years in West and Central Africa. Because only one of the seven proteins encoded by the viral genome possesses enzymatic activity, disruption of protein-protein interactions is a promising route for antiviral drug development. We carried out a ...

journal_title：Biomolecular NMR assignments

authors： Lee W,Tonelli M,Wu C,Aceti DJ,Amarasinghe GK,Markley JL

更新日期：2019-10-01 00:00:00

abstract：:During its life cycle, the malaria parasite Plasmodium falciparum is found intracellular to human erythrocytes, where its survival and ability to multiply critically depends on the control of the environment redox state. Thioredoxin is a small protein containing 104 amino acids that is part of the parasite specific re...

journal_title：Biomolecular NMR assignments

authors： Munte CE,Becker K,Schirmer RH,Kalbitzer HR

更新日期：2009-12-01 00:00:00

abstract：:The replication of the hepatitis B virus is initiated by binding of the viral reverse transcriptase protein complex to the apical stem loop of the epsilon element to place it next to the primer loop, from which a four nucleotide DNA primer is subsequently synthesized. Here, we present the (1)H/(13)C/(15)N NMR assignme...

journal_title：Biomolecular NMR assignments

authors： van der Werf RM,Girard FC,Nelissen F,Tessari M,Wijmenga SS

更新日期：2008-12-01 00:00:00

abstract：:Heterogeneous nuclear ribonucleoproteins (hnRNPs) can be divided into subgroups based on their RNA-binding characteristics. One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or α-complex proteins (α-CP) 1-4]. Each subgroup ...

journal_title：Biomolecular NMR assignments

authors： Li Y,Hennig M

更新日期：2015-10-01 00:00:00

abstract：:We report here the resonance assignment of EDK-∆-Bd37, conformational mutant potentially displaying the "open" conformation of Bd37, a 25 kDa surface protein from the Apicomplexa parasite Babesia divergens that could undergo drastic conformational changes during erythrocyte invasion. ...

journal_title：Biomolecular NMR assignments

authors： Barthe P,Murciano B,Schetters T,Gorenflot A,Delbecq S,Roumestand C

更新日期：2013-10-01 00:00:00

abstract：:YbeA is a 3-methylpseudoridine methyltransferase from Escherichia coli that forms a stable homodimer in solution. It is one of the deeply trefoil 31 knotted proteins, of which the knot encompasses the C-terminal helix that threads through a long loop. Recent studies on the knotted protein folding pathways using YbeA h...

journal_title：Biomolecular NMR assignments

authors： Hsieh SJ,Mallam AL,Jackson SE,Hsu ST

更新日期：2014-10-01 00:00:00

abstract：:The apo-form of the 21.4 kDa catalytic domain and the 10.7 kDa carbohydrate binding domain of the AA10 family lytic polysaccharide monooxygenase ScLPMO10C from Streptomyces coelicolor have been isotopically labeled and recombinantly expressed in Escherichia coli. In this paper, we report the 1H, 13C, and 15N chemical ...

journal_title：Biomolecular NMR assignments

authors： Courtade G,Forsberg Z,Vaaje-Kolstad G,Eijsink VGH,Aachmann FL

更新日期：2017-10-01 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) 4 has been associated with progression of melanoma, breast, head and neck and hepatocellular carcinoma and is therefore an interesting target for therapeutic intervention (Ho et al. in J Hepatol 50:118-127, 2009). The extracellular D2 domain of the FGFR4 receptor contains a hep...

journal_title：Biomolecular NMR assignments

authors： Elshorst B,Saxena K,Schieborr U,Schwalbe H

更新日期：2013-10-01 00:00:00

abstract：:Tensin is an important cytoplasmic phosphoprotein localized to integrin-mediated focal adhesion. It links actin cytoskeleton to extracellular matrix through its N-terminal actin-binding domain and C-terminal phosphotyrosine-binding domain. Studies of knockout mice revealed the critical roles of tensin in skeletal musc...

journal_title：Biomolecular NMR assignments

authors： Chen L,Liu C,Rui F,Zhu G

更新日期：2011-10-01 00:00:00

abstract：:The protein dimethyladenosine transferase 1 (Dim1) is a highly conserved protein occurring in organisms ranging from bacteria such as E. coli where it is named KsgA to humans. Since Dim1 is involved in the biogenesis of the small ribosomal subunit it is an essential protein. During ribosome biogenesis Dim1 acts as an ...

journal_title：Biomolecular NMR assignments

authors： Kaiser M,Hacker C,Duchardt-Ferner E,Wöhnert J

更新日期：2019-10-01 00:00:00

abstract：:Cohesin and dockerin domains are critical assembling components of cellulosome, a large extracellular multienzyme complex which is used by anaerobic cellulolytic bacteria to efficiently degrade lignocellulose. According to sequence homology, cohesins can be divided into three major groups, whereas cohesins from Clostr...

journal_title：Biomolecular NMR assignments

authors： Cui Z,Li Y,Xiao Y,Feng Y,Cui Q

更新日期：2013-04-01 00:00:00

abstract：:Bacterial thiol peroxidases (Tpxs) are antioxidant enzymes which exist in various bacteria. Tpxs reduce the lipid hydroperoxides to protect the membrane lipid from destruction by reactive oxygen species. Tpxs are essential enzymes for bacterial anaerobic growth. Herein, we report the resonance assignments of (1)H, (13...

journal_title：Biomolecular NMR assignments

authors： Lu J,Yang F,Li Y,Xia B,Jin C

更新日期：2008-12-01 00:00:00

abstract：:The A. thaliana RCD1 (radical-induced cell death1) protein is a cellular signaling hub protein which interacts with numerous plant transcription factors from different families. It consists of three conserved domains and intervening unstructured regions, the C-terminal RST domain being responsible for the interactions...

journal_title：Biomolecular NMR assignments

authors： Tossavainen H,Hellman M,Vainonen JP,Kangasjärvi J,Permi P

更新日期：2017-10-01 00:00:00

abstract：:The actin filament dynamics in nematode, Caenorhabditis elegans, is regulated by differential activity of two proteins UNC-60A and UNC-60B. UNC-60A exhibits strong pointed end depolymerization on C. elegans actin (Ce-actin), strong inhibition of polymerization, strong monomer sequestering activity, weak severing activ...

journal_title：Biomolecular NMR assignments

authors： Shukla VK,Kabra A,Yadav R,Ono S,Kumar D,Arora A

更新日期：2015-10-01 00:00:00

abstract：:The Breast Cancer susceptibility protein 2 (BRCA2) is involved in mechanisms that maintain genome stability, including DNA repair, replication and cell division. These functions are ensured by the folded C-terminal DNA binding domain of BRCA2 but also by its large regions predicted to be disordered. Several studies ha...

journal_title：Biomolecular NMR assignments

authors： Julien M,Miron S,Carreira A,Theillet FX,Zinn-Justin S

更新日期：2020-04-01 00:00:00

abstract：:Bacillus subtilis ATCC 6633 produces the lipid II targeting lantibiotic subtilin. For self-protection these gram-positive bacteria express a cluster of four self-immunity proteins named SpaIFEG. SpaI is a 16.8 kDa lipoprotein which is attached to the outside of the cytoplasmic membrane via a covalently linked diacylgl...

journal_title：Biomolecular NMR assignments

authors： Christ NA,Duchardt-Ferner E,Düsterhus S,Kötter P,Entian KD,Wöhnert J

更新日期：2012-04-01 00:00:00

abstract：:GNA2132 (Genome-derived Neisseria Antigen 2132) is a surface-exposed lipoprotein discovered by reverse vaccinology and expressed by genetically diverse Neisseria meningitidis strains (Pizza et al. 2000). The protein induces bactericidal antibodies against most strains of Meningococccus and has been included in a multi...

journal_title：Biomolecular NMR assignments

authors： Esposito V,Musi V,Veggi D,Pastore A,Pizza M

更新日期：2010-04-01 00:00:00

abstract：:We report the nearly complete 1H, 13C and 15N resonance assignments of the oxidized form (Cys(67)-Cys(70)) of the N-terminal domain of PilB from Neisseria meningitidis. Secondary structure determination using CSI method and TALOS leads mainly to the prediction of 7 alpha-helical and 5 beta-sheet parts. ...

journal_title：Biomolecular NMR assignments

authors： Quinternet M,Beaufils C,Neiers F,Tsan P,Boschi-Muller S,Averlant-Petit MC,Branlant G,Cung MT

更新日期：2007-07-01 00:00:00

abstract：:LicT belongs to an essential family of bacterial antitermination proteins which bind to nascent mRNAs in order to stimulate transcription of sugar-metabolizing operons. As most of other antitermination proteins involved in carbohydrate metabolism, LicT is composed of a N-terminal RNA-binding module (CAT) and two homol...

journal_title：Biomolecular NMR assignments

authors： Yang Y,Declerck N,Déméné H

更新日期：2020-04-01 00:00:00

abstract：:Early response to dehydration 10 protein (ERD10) is an intrinsically disordered protein from Arabidopsis thaliana. The protein is upregulated during stress however its mechanism of action at atomic level is not well understood. In the present work multidimensional NMR methodologies are used in order to facilitate the ...

journal_title：Biomolecular NMR assignments

authors： Cedeño C,Żerko S,Tompa P,Koźmiński W

更新日期：2017-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease, where dopaminergic cells die most prominently in the area of substantia nigra. Neurotrophic factors (NTFs) are secreted proteins, which upon binding to their target receptors trigger survival pathways to prevent neuronal loss. Recently disco...

journal_title：Biomolecular NMR assignments

authors： Hellman M,Peränen J,Saarma M,Permi P

更新日期：2010-10-01 00:00:00

abstract：:The archaeal protein L7Ae forms part of a protein complex in the ribosome that specifically recognizes and binds to kink-turn RNA. In this complex, L7Ae directly interacts with the oligonucleotide and creates a functional arrangement for site-specific 2'-O-methylation. We report the solution NMR backbone assignment of...

journal_title：Biomolecular NMR assignments

authors： Moschen T,Wunderlich C,Kreutz C,Tollinger M

更新日期：2015-04-01 00:00:00

abstract：:Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib. ...

journal_title：Biomolecular NMR assignments

authors： Vajpai N,Strauss A,Fendrich G,Cowan-Jacob SW,Manley PW,Jahnke W,Grzesiek S

更新日期：2008-06-01 00:00:00

abstract：:The 19.9 kDa C-terminal module (R3) from Azotobacter vinelandii mannronan C5-epimerase AlgE6 has been (13)C, (15)N isotopically labelled and recombinantly expressed. We report here the (1)H, (13)C, (15)N resonance assignment of AlgE6R3. ...

journal_title：Biomolecular NMR assignments

authors： Buchinger E,Skjåk-Bræk G,Valla S,Wimmer R,Aachmann FL

更新日期：2011-04-01 00:00:00

abstract：:E. coli nitroreductase NfsB (also called NfnB) has been studied extensively, largely due to its potential for cancer gene therapy. A homodimeric flavoprotein of 216 residues, it catalyses the reduction of nitroaromatics to cytotoxic hydroxylamines by NADH and NADPH and also the reduction of quinones to hydroxyquinones...

journal_title：Biomolecular NMR assignments

authors： Hyde EI,Chau AK,Smith LJ

更新日期：2021-01-09 00:00:00

abstract：:Tuberculosis is one of the deadliest diseases worldwide affecting approximately 10 million people in 2018. This classifies tuberculosis as epidemic in several countries and leads to an increasing number of multidrug-resistant strains. Thus, the development of new drugs is essential to effective treatments. A potential...

journal_title：Biomolecular NMR assignments

authors： Bartkevihi L,Martins B,de Oliveira DMP,Pires JRM,Anobom CD,Almeida FCL

更新日期：2020-04-01 00:00:00