Abstract：
:During its life cycle, the malaria parasite Plasmodium falciparum is found intracellular to human erythrocytes, where its survival and ability to multiply critically depends on the control of the environment redox state. Thioredoxin is a small protein containing 104 amino acids that is part of the parasite specific redox system. During the catalytic cycle it alternates between a reduced and oxidised form. Here we report the complete resonance assignment of Plasmodium falciparum thioredoxin in its oxidized form by heteronuclear multidimensional spectroscopy. The obtained chemical shifts differ significantly from those reported earlier for this protein in its reduced state.
journal_name
Biomol NMR Assignjournal_title
Biomolecular NMR assignmentsauthors
Munte CE,Becker K,Schirmer RH,Kalbitzer HRdoi
10.1007/s12104-009-9163-7subject
Has Abstractpub_date
2009-12-01 00:00:00pages
159-61issue
2eissn
1874-2718issn
1874-270Xjournal_volume
3pub_type
杂志文章abstract：:Light chain (AL) amyloidosis is a systemic disease characterized by the formation of immunoglobulin light-chain fibrils in critical organs of the body. The light-chain protein AL-09 presents one severe case of cardiac AL amyloidosis, which contains seven mutations in the variable domain (VL) relative to its germline c...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-016-9718-3
更新日期：2017-04-01 00:00:00
abstract：:Plasmodium falciparum is responsible for causing cerebral malaria in humans. IMP1 is an immunogenic protein, present in the parasite, which has been shown to induce an immune response against apicomplexan parasites in a species-specific manner. Here, we report the complete NMR assignments of PfIMP1. ...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-015-9616-0
更新日期：2015-10-01 00:00:00
abstract：:The replication of the hepatitis B virus is initiated by binding of the viral reverse transcriptase protein complex to the apical stem loop of the epsilon element to place it next to the primer loop, from which a four nucleotide DNA primer is subsequently synthesized. Here, we present the (1)H/(13)C/(15)N NMR assignme...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-008-9106-8
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abstract：:The pathogenic bacterium Staphylococcus aureus has evolved to actively evade many aspects of the human innate immune system by expressing a series of secreted inhibitory proteins. Among these, the extracellular adherence protein (Eap) has been shown to inhibit the classical and lectin pathways of the complement system...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-016-9688-5
更新日期：2016-10-01 00:00:00
abstract：:Hydrophobins are fungal proteins characterised by their amphipathic properties and an idiosyncratic pattern of eight cysteine residues involved in four disulphide bridges. The soluble form of these proteins spontaneously self-assembles at hydrophobic/hydrophilic interfaces to form an amphipathic monolayer. The RodA hy...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-014-9555-1
更新日期：2015-04-01 00:00:00
abstract：:The Src tyrosine kinase is the paradigm of an oncogenic kinase, and of regulation by intramolecular inhibitory interactions, as well as an important anticancer target due to its roles in cell proliferation and metastasis. The assignment of backbone (1)H(N), (13)C(α), (13)CO, and (15)N, and sidechain (13)C(β) resonance...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-011-9304-7
更新日期：2011-10-01 00:00:00
abstract：:Hsp70 chaperone proteins play crucial roles in the cell. Extensive structural and functional studies have been performed for bacterial and mammalian Hsp70s. Ssa1 from Saccharomyces cerevisiae is a member of the Hsp70 family. In vivo and biochemical studies on Ssa1 have revealed that it regulates prion propagation and ...
journal_title：Biomolecular NMR assignments
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doi：10.1007/s12104-015-9603-5
更新日期：2015-10-01 00:00:00
abstract：:The archaeal protein L7Ae forms part of a protein complex in the ribosome that specifically recognizes and binds to kink-turn RNA. In this complex, L7Ae directly interacts with the oligonucleotide and creates a functional arrangement for site-specific 2'-O-methylation. We report the solution NMR backbone assignment of...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-014-9569-8
更新日期：2015-04-01 00:00:00
abstract：:The catalytic subunit of protein kinase A is involved with a number of signal transduction pathways and has been used as a benchmark to study the structural biology and biochemistry for the entire kinase family of enzymes. Here, we report the backbone assignment of the intact 41 kDa catalytic subunit bound to AMP-PNP....
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-009-9154-8
更新日期：2009-06-01 00:00:00
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-010-9269-y
更新日期：2011-04-01 00:00:00
abstract：:Human voltage-gated sodium (NaV) channels are critical for initiating and propagating action potentials in excitable cells. Nine isoforms have different roles but similar topologies, with a pore-forming α-subunit and auxiliary transmembrane β-subunits. NaV pathologies lead to debilitating conditions including epilepsy...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-018-9824-5
更新日期：2018-10-01 00:00:00
abstract：:The C-terminally truncated Y145Stop variant of prion protein (PrP23-144) has been linked to a heritable prionopathy in humans and is also capable of triggering a transmissible prion disease in mice. PrP23-144 can be converted from soluble monomeric form to amyloid under physiological conditions, providing an in vitro ...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-020-09981-4
更新日期：2020-10-29 00:00:00
abstract：:Repressor of primer (Rop, or ROM, RNA I modulator) is a 63 amino acid four-helix bundle protein that exists in solution as an anti-parallel homodimer. This protein has been extensively studied, including by X-ray crystallography, NMR, rational design, and combinatorial mutagenesis. Previous NMR experiments with wild-t...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-018-9837-0
更新日期：2018-10-01 00:00:00
abstract：:FK506 Binding Proteins (FKBPs) are a family of highly conserved and important proteins that possess a peptidyl cis-trans isomerase (PPIases) domain. Human FKBP12 is a prototype of this family and it is involved in many diseases due to its interaction with the immunosuppressive drugs FK506 and rapamycin. They inhibit c...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-019-09884-z
更新日期：2019-04-01 00:00:00
abstract：:PRK1 is a member of the protein kinase C-related kinase (PRK) family of serine/threonine kinases and a downstream effector of Rho GTPases. PRK1 has three N-terminal Homology Region 1 (HR1) domains (HR1a, HR1b and HR1c), which form antiparallel coiled coils that interact with Rho family GTPases. PRK1 also has a C2-like...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-020-09954-7
更新日期：2020-10-01 00:00:00
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-013-9476-4
更新日期：2014-04-01 00:00:00
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-018-9864-x
更新日期：2019-04-01 00:00:00
abstract：:TAR RNA binding protein (TRBP) is a double-stranded RNA binding protein involved in various biological processes like cell growth, development, death, etc. The protein exists as two isoforms TRBP2 and TRBP1. TRBP2 contains additional 21 amino acids at its N-terminus, which are proposed to be involved in its membrane l...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-018-9807-6
更新日期：2018-04-01 00:00:00
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-007-9050-z
更新日期：2007-12-01 00:00:00
abstract：:Snu13p is a highly conserved RNA binding protein from Saccharomyces cerevisiae required for both eukaryotic pre-mRNA splicing and pre-rRNA processing. The 1H, 13C, and 15N assignments were determined from multidimensional, multinuclear NMR experiments conducted at 25 degrees C. ...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-007-9069-1
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-015-9602-6
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-016-9678-7
更新日期：2016-10-01 00:00:00
abstract：:Tuberculosis is one of the deadliest diseases worldwide affecting approximately 10 million people in 2018. This classifies tuberculosis as epidemic in several countries and leads to an increasing number of multidrug-resistant strains. Thus, the development of new drugs is essential to effective treatments. A potential...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-020-09931-0
更新日期：2020-04-01 00:00:00
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-008-9134-4
更新日期：2009-06-01 00:00:00
abstract：:The bacterium Geobacter metallireducens is capable of transferring electrons to the cell exterior, a process designated extracellular electron transfer. This mechanism allows the microorganism to reduce extracellular acceptors such as Fe(III) (hydr)oxides and water toxic and/or radioactive contaminants including Cr(VI...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-019-09916-8
更新日期：2020-04-01 00:00:00
abstract：:Galectins recognize β-galectosides to promote a variety of cellular functions. Despite their sequence variations, all galectins share the same carbohydrate recognition domains (CRD) and their modes of ligand recognition at a structural level are essentially identical. Human galectin 8 plays an important role in numero...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-015-9623-1
更新日期：2015-10-01 00:00:00
abstract：:In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 ...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-017-9754-7
更新日期：2017-10-01 00:00:00
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journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-014-9588-5
更新日期：2015-10-01 00:00:00
abstract：:The apo-form of the 21.4 kDa catalytic domain and the 10.7 kDa carbohydrate binding domain of the AA10 family lytic polysaccharide monooxygenase ScLPMO10C from Streptomyces coelicolor have been isotopically labeled and recombinantly expressed in Escherichia coli. In this paper, we report the 1H, 13C, and 15N chemical ...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-017-9759-2
更新日期：2017-10-01 00:00:00
abstract：:Early response to dehydration 10 protein (ERD10) is an intrinsically disordered protein from Arabidopsis thaliana. The protein is upregulated during stress however its mechanism of action at atomic level is not well understood. In the present work multidimensional NMR methodologies are used in order to facilitate the ...
journal_title：Biomolecular NMR assignments
pub_type： 杂志文章
doi：10.1007/s12104-017-9732-0
更新日期：2017-10-01 00:00:00
