Abstract:
:Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease, where dopaminergic cells die most prominently in the area of substantia nigra. Neurotrophic factors (NTFs) are secreted proteins, which upon binding to their target receptors trigger survival pathways to prevent neuronal loss. Recently discovered NTFs mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF) most efficiently protect and repair the dopaminergic neurons in the animal 6-OHDA models of PD. However, the neuroprotective mechanism of MANF/CDNF is currently elusive. To this end, we have employed high-resolution NMR spectroscopy to determine three-dimensional structure of full-length human MANF in solution and characterized C-terminal domain as structural unit of MANF protein.
journal_name
Biomol NMR Assignjournal_title
Biomolecular NMR assignmentsauthors
Hellman M,Peränen J,Saarma M,Permi Pdoi
10.1007/s12104-010-9251-8subject
Has Abstractpub_date
2010-10-01 00:00:00pages
215-7issue
2eissn
1874-2718issn
1874-270Xjournal_volume
4pub_type
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