Sequence-specific backbone ¹H, ¹³C and ¹⁵N assignments of the 34 kDa catalytic domain of PTPN5 (STEP).

abstract：:Phosphoethanolamine methyltransferases (PMTs also known as PEAMTs) catalyze the three-step s-adenosyl-methionione-dependent methylation of phosphoethanolamine to form phosphocholine. These enzymes play an important function in the synthesis of phosphatidylcholine, the major phospholipid in the membranes of lower and h...

journal_title：Biomolecular NMR assignments

authors： Bezsonova I,Rujan I,Bobenchik AM,Gorbatyuk V,Maciejewski MW,Gorbatyuk O,Hao B,Arthanari H,Mamoun CB,Hoch JC

更新日期：2013-04-01 00:00:00

abstract：:Plasmodium falciparum is responsible for causing cerebral malaria in humans. IMP1 is an immunogenic protein, present in the parasite, which has been shown to induce an immune response against apicomplexan parasites in a species-specific manner. Here, we report the complete NMR assignments of PfIMP1. ...

journal_title：Biomolecular NMR assignments

authors： Benjamin S,Williams F,Kerry L,Matthews S

更新日期：2015-10-01 00:00:00

abstract：:A peptide or a small protein released from an exocrine gland or in urine is utilized as a chemosignal that elicits social or reproductive behavior in mice. Recently, we identified the male-specific peptide, exocrine gland-secreting peptide 1 (ESP1), in mouse tear fluids that enhanced female sexual receptive behavior, ...

journal_title：Biomolecular NMR assignments

authors： Taniguchi M,Yoshinaga S,Haga-Yamanaka S,Touhara K,Terasawa H

更新日期：2014-04-01 00:00:00

abstract：:Ubiquitin Specific Protease 25 (USP25), a member of the deubiquitinase family, is involved in several disease-related signal pathways including myogenesis, immunity and protein degradation. It specially catalyzes the hydrolysis of the K48-linked and K63-linked polyubiquitin chains. USP25 contains one ubiquitin-associa...

journal_title：Biomolecular NMR assignments

authors： Shi L,Wen Y,Zhang N

更新日期：2014-10-01 00:00:00

abstract：:Arsenate reductases (ArsC) are a group of enzymes that play essential roles in biological arsenic detoxification pathways by catalyzing the intracellular reduction of arsenate to arsenite, which is subsequently extruded from the cells by specific transport systems. The ArsC protein from cyanobacterium Synechocystis sp...

journal_title：Biomolecular NMR assignments

authors： Yu C,Xia B,Jin C

更新日期：2011-04-01 00:00:00

abstract：:Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib. ...

journal_title：Biomolecular NMR assignments

authors： Vajpai N,Strauss A,Fendrich G,Cowan-Jacob SW,Manley PW,Jahnke W,Grzesiek S

更新日期：2008-06-01 00:00:00

abstract：:KKT4 is a kinetoplastid-specific microtubule-binding kinetochore protein that lacks significant similarity to any known kinetochore or microtubule-binding proteins. Here we present the 1H, 13C and 15N resonance assignments for several fragments from the microtubule-binding domain of KKT4 (KKT4115-343) from Trypanosoma...

journal_title：Biomolecular NMR assignments

authors： Ludzia P,Akiyoshi B,Redfield C

更新日期：2020-10-01 00:00:00

abstract：:Tensin is an important cytoplasmic phosphoprotein localized to integrin-mediated focal adhesion. It links actin cytoskeleton to extracellular matrix through its N-terminal actin-binding domain and C-terminal phosphotyrosine-binding domain. Studies of knockout mice revealed the critical roles of tensin in skeletal musc...

journal_title：Biomolecular NMR assignments

authors： Chen L,Liu C,Rui F,Zhu G

更新日期：2011-10-01 00:00:00

abstract：:Ebola viral infections have resulted in several deadly epidemics in recent years in West and Central Africa. Because only one of the seven proteins encoded by the viral genome possesses enzymatic activity, disruption of protein-protein interactions is a promising route for antiviral drug development. We carried out a ...

journal_title：Biomolecular NMR assignments

authors： Lee W,Tonelli M,Wu C,Aceti DJ,Amarasinghe GK,Markley JL

更新日期：2019-10-01 00:00:00

abstract：:Translation initiation factor 3 (IF3) is one of the three protein factors that bind to the small ribosomal subunit and it is required for the initiation of protein biosynthesis in bacteria. IF3 contains two independent domains, N- and C-terminal domains, which are connected by a lysine-rich interdomain linker. IF3 und...

journal_title：Biomolecular NMR assignments

authors： Li L,Palmer SO,Gomez EA,Mendiola F,Wang T,Bullard JM,Zhang Y

更新日期：2020-04-01 00:00:00

abstract：:Nuclear Factor κB (NF-κB) is a family of five related transcription factors that recognize a κB DNA element on the promoter and enhancer regions of target genes and modulate their expression. Here we report a complete set of 1H, 13C, 15N backbone and side chain resonance assignments for the p50 DNA binding and dimeriz...

journal_title：Biomolecular NMR assignments

authors： Singh A,Dyson HJ

更新日期：2020-09-16 00:00:00

abstract：:The S100 family belongs to the EF-hand calcium-binding proteins regulating a wide range of important cellular processes via protein-protein interactions. Most S100 proteins adopt a conformation of non-covalent homodimer for their functions. Calcium binding to the EF-hand motifs of S100 proteins is essential for trigge...

journal_title：Biomolecular NMR assignments

authors： Hung KW,Chang YM,Yu C

更新日期：2013-10-01 00:00:00

abstract：:Hsp70 chaperone proteins play crucial roles in the cell. Extensive structural and functional studies have been performed for bacterial and mammalian Hsp70s. Ssa1 from Saccharomyces cerevisiae is a member of the Hsp70 family. In vivo and biochemical studies on Ssa1 have revealed that it regulates prion propagation and ...

journal_title：Biomolecular NMR assignments

authors： Hu W,Wu H,Zhang H,Gong W,Perrett S

更新日期：2015-10-01 00:00:00

abstract：:FK506 Binding Proteins (FKBPs) are a family of highly conserved and important proteins that possess a peptidyl cis-trans isomerase (PPIases) domain. Human FKBP12 is a prototype of this family and it is involved in many diseases due to its interaction with the immunosuppressive drugs FK506 and rapamycin. They inhibit c...

journal_title：Biomolecular NMR assignments

authors： Andrade GC,Silva LFC,Oliveira DMP,Pires JRM,Almeida FCL,Anobom CD

更新日期：2019-04-01 00:00:00

abstract：:The C-terminally truncated Y145Stop variant of prion protein (PrP23-144) has been linked to a heritable prionopathy in humans and is also capable of triggering a transmissible prion disease in mice. PrP23-144 can be converted from soluble monomeric form to amyloid under physiological conditions, providing an in vitro ...

journal_title：Biomolecular NMR assignments

authors： Dao HH,Hlaing MZ,Ma Y,Surewicz K,Surewicz WK,Jaroniec CP

更新日期：2020-10-29 00:00:00

abstract：:LicT belongs to an essential family of bacterial antitermination proteins which bind to nascent mRNAs in order to stimulate transcription of sugar-metabolizing operons. As most of other antitermination proteins involved in carbohydrate metabolism, LicT is composed of a N-terminal RNA-binding module (CAT) and two homol...

journal_title：Biomolecular NMR assignments

authors： Yang Y,Declerck N,Déméné H

更新日期：2020-04-01 00:00:00

abstract：:Chromatin remodelling proteins are an essential family of eukaryotic proteins. They harness the energy from ATP hydrolysis and apply it to alter chromatin structure in order to regulate all aspects of genome biology. Chromodomain helicase DNA-binding protein 1 (CHD1) is one such remodelling protein that has specialise...

journal_title：Biomolecular NMR assignments

authors： Mohanty B,Silva AP,Mackay JP,Ryan DP

更新日期：2016-04-01 00:00:00

abstract：:NOXO1 (Nox Organizer 1) is a homolog of the NAPDH oxidase protein p47(phox). NADPH oxidases transfer electrons from NADPH to molecular oxygen, generating the superoxide anion. NOXO1 contains an N-terminal PX (phox homology) domain and is one of several PX domain-containing proteins found in the cytosolic subunits of t...

journal_title：Biomolecular NMR assignments

authors： Davis NY,McPhail LC,Horita DA

更新日期：2011-10-01 00:00:00

abstract：:The archaeal protein L7Ae forms part of a protein complex in the ribosome that specifically recognizes and binds to kink-turn RNA. In this complex, L7Ae directly interacts with the oligonucleotide and creates a functional arrangement for site-specific 2'-O-methylation. We report the solution NMR backbone assignment of...

journal_title：Biomolecular NMR assignments

authors： Moschen T,Wunderlich C,Kreutz C,Tollinger M

更新日期：2015-04-01 00:00:00

abstract：:In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 ...

journal_title：Biomolecular NMR assignments

authors： Ahammer L,Grutsch S,Wallner M,Ferreira F,Tollinger M

更新日期：2017-10-01 00:00:00

abstract：:We present the backbone and sidechain NMR assignments and a structural analysis of the 178-residue wild-type γS-crystallin and the cataract-related point mutant, γS-G18V. γS-crystallin is a structural component of the eye lens, which maintains its solubility and stability over many years. NMR assignments and continued...

journal_title：Biomolecular NMR assignments

authors： Brubaker WD,Martin RW

更新日期：2012-04-01 00:00:00

abstract：:S100A15 (koebnerisin) is overexpressed in psoriatic skin and displays distinct localizations in skin and breast with divergent functions in inflammation. Here we report the backbone and side-chain resonance assignments for the Ca(2+)-bound human S100A15. ...

journal_title：Biomolecular NMR assignments

authors： Cho CC,Hung KW,Yu C

更新日期：2014-04-01 00:00:00

abstract：:Human voltage-gated sodium (NaV) channels are critical for initiating and propagating action potentials in excitable cells. Nine isoforms have different roles but similar topologies, with a pore-forming α-subunit and auxiliary transmembrane β-subunits. NaV pathologies lead to debilitating conditions including epilepsy...

journal_title：Biomolecular NMR assignments

authors： Isbell HM,Kilpatrick AM,Lin Z,Mahling R,Shea MA

更新日期：2018-10-01 00:00:00

abstract：:Cohesin and dockerin domains are critical assembling components of cellulosome, a large extracellular multienzyme complex which is used by anaerobic cellulolytic bacteria to efficiently degrade lignocellulose. According to sequence homology, cohesins can be divided into three major groups, whereas cohesins from Clostr...

journal_title：Biomolecular NMR assignments

authors： Cui Z,Li Y,Xiao Y,Feng Y,Cui Q

更新日期：2013-04-01 00:00:00

abstract：:RpsA, also known as ribosomal protein S1, is an essential protein required for translation initiation of mRNAs when their Shine-Dalgarno sequence is degenerated (Sorensen et al. 1998). In addition, RpsA of Mycobacterium tuberculosis (M. tb) is involved in trans-translation, which is an effective system mediated by tmR...

journal_title：Biomolecular NMR assignments

authors： Fu J,Huang B,Lin D,Liao X

更新日期：2017-10-01 00:00:00

abstract：:The bacterium Geobacter metallireducens is capable of transferring electrons to the cell exterior, a process designated extracellular electron transfer. This mechanism allows the microorganism to reduce extracellular acceptors such as Fe(III) (hydr)oxides and water toxic and/or radioactive contaminants including Cr(VI...

journal_title：Biomolecular NMR assignments

authors： Portela PC,Dantas JM,Salgueiro CA

更新日期：2020-04-01 00:00:00

abstract：:We report here the resonance assignment of EDK-∆-Bd37, conformational mutant potentially displaying the "open" conformation of Bd37, a 25 kDa surface protein from the Apicomplexa parasite Babesia divergens that could undergo drastic conformational changes during erythrocyte invasion. ...

journal_title：Biomolecular NMR assignments

authors： Barthe P,Murciano B,Schetters T,Gorenflot A,Delbecq S,Roumestand C

更新日期：2013-10-01 00:00:00

abstract：:Norovirus protease cleaves the virus-encoded polyprotein into six mature nonstructural proteins, presenting itself as an essential enzyme for the viral replication as well as an attractive target for the antiviral drug development. A deeper understanding of the structural mechanism of the protease-substrates/inhibitor...

journal_title：Biomolecular NMR assignments

authors： Takahashi D,Kim Y,Chang KO,Anbanandam A,Prakash O

更新日期：2012-04-01 00:00:00

abstract：:Bacterial thiol peroxidases (Tpxs) are antioxidant enzymes which exist in various bacteria. Tpxs reduce the lipid hydroperoxides to protect the membrane lipid from destruction by reactive oxygen species. Tpxs are essential enzymes for bacterial anaerobic growth. Herein, we report the resonance assignments of (1)H, (13...

journal_title：Biomolecular NMR assignments

authors： Lu J,Yang F,Li Y,Xia B,Jin C

更新日期：2008-12-01 00:00:00

abstract：:ITCH (aka Atrophin-1-interacting protein 4) is a prominent member of the NEDD4 HECT (Homologous to E6AP C-Terminus) E3 ubiquitin ligase family that regulates numerous cellular functions including inflammatory responses through T-cell activation, cell differentiation, and apoptosis. Known intracellular targets of ITCH-...

journal_title：Biomolecular NMR assignments

authors： Beasley SA,Bardhi R,Spratt DE

更新日期：2019-04-01 00:00:00