Abstract:
:The S100 family belongs to the EF-hand calcium-binding proteins regulating a wide range of important cellular processes via protein-protein interactions. Most S100 proteins adopt a conformation of non-covalent homodimer for their functions. Calcium binding to the EF-hand motifs of S100 proteins is essential for triggering the structural changes, promoting exposure of hydrophobic regions necessary for target protein interactions. S100A11 is a protein found in diverse tissues and possesses multiple functions upon binding to different target proteins. RAGE is a multiligand receptor binding to S100A11 and the interactions at molecular level have not been reported. However, the three-dimensional structure of human S100A11 containing 105 amino acids is still not available for further interaction studies. To determine the solution structure, for the first time we report the (1)H, (15)N and (13)C resonance assignments and protein secondary structure prediction of human S100A11 dimer in complex with calcium using a variety of triple resonance NMR experiments and the chemical shift index (CSI) method, respectively.
journal_name
Biomol NMR Assignjournal_title
Biomolecular NMR assignmentsauthors
Hung KW,Chang YM,Yu Cdoi
10.1007/s12104-012-9412-zsubject
Has Abstractpub_date
2013-10-01 00:00:00pages
211-4issue
2eissn
1874-2718issn
1874-270Xjournal_volume
7pub_type
杂志文章abstract::Yeast Fpr4p belongs to the FK506-binding protein (FKBP) class of peptidyl proline isomerases (PPIases), and has been implicated in regulating the cis-trans conversion of proline residues within histone tails. Here we report the (1)H, (13)C and (15)N chemical shift assignments for the bacterially expressed C-terminal P...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-011-9338-x
更新日期:2012-10-01 00:00:00
abstract::Vibrio cholerae is the bacterial causative agent of the human disease cholera. Non-pathogenic bacterium can be converted to pathogenic following infection by a filamentous phage, CTXΦ, that carries the cholera toxin encoding genes. A crucial step during phage infection requires a direct interaction between the CTXΦ mi...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-016-9690-y
更新日期:2016-10-01 00:00:00
abstract::TraI, the F plasmid-encoded nickase, is a 1,756 amino acid protein essential for conjugative transfer of F plasmid DNA from one bacterium to another. While crystal structures of N- and C-terminal domains of F TraI have been determined, central domains of the protein are structurally unexplored. These middle domains (b...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9269-y
更新日期:2011-04-01 00:00:00
abstract::The agglutinin-like-sequence (ALS) family of adhesion proteins are a key virulence factor for C. albicans. These proteins have been implicated in several functions, notably adhesion and invasion of different cell types, as well as binding to peptides and proteins in the cell surface and extracellular matrix. In order ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9243-8
更新日期:2010-10-01 00:00:00
abstract::Tuberculosis is one of the deadliest diseases worldwide affecting approximately 10 million people in 2018. This classifies tuberculosis as epidemic in several countries and leads to an increasing number of multidrug-resistant strains. Thus, the development of new drugs is essential to effective treatments. A potential...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-020-09931-0
更新日期:2020-04-01 00:00:00
abstract::E. coli nitroreductase NfsB (also called NfnB) has been studied extensively, largely due to its potential for cancer gene therapy. A homodimeric flavoprotein of 216 residues, it catalyses the reduction of nitroaromatics to cytotoxic hydroxylamines by NADH and NADPH and also the reduction of quinones to hydroxyquinones...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-020-09997-w
更新日期:2021-01-09 00:00:00
abstract::Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen and a primary cause of infection in humans. P. aeruginosa can acquire resistance against multiple groups of antimicrobial agents, including β-lactams, aminoglycosides and fluoroquinolones, and multidrug resistance is increasing in this organism which mak...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-016-9678-7
更新日期:2016-10-01 00:00:00
abstract::Repressor of primer (Rop, or ROM, RNA I modulator) is a 63 amino acid four-helix bundle protein that exists in solution as an anti-parallel homodimer. This protein has been extensively studied, including by X-ray crystallography, NMR, rational design, and combinatorial mutagenesis. Previous NMR experiments with wild-t...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-018-9837-0
更新日期:2018-10-01 00:00:00
abstract::NOXO1 (Nox Organizer 1) is a homolog of the NAPDH oxidase protein p47(phox). NADPH oxidases transfer electrons from NADPH to molecular oxygen, generating the superoxide anion. NOXO1 contains an N-terminal PX (phox homology) domain and is one of several PX domain-containing proteins found in the cytosolic subunits of t...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9286-x
更新日期:2011-10-01 00:00:00
abstract::Translation initiation factor 3 (IF3) is one of the three protein factors that bind to the small ribosomal subunit and it is required for the initiation of protein biosynthesis in bacteria. IF3 contains two independent domains, N- and C-terminal domains, which are connected by a lysine-rich interdomain linker. IF3 und...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-020-09926-x
更新日期:2020-04-01 00:00:00
abstract::The PilF protein from the thermophilic bacterium Thermus thermophilus is a traffic ATPase powering the assembly of the DNA translocation machinery as well as of type 4 pili. Thereby PilF mediates the natural transformability of T. thermophilus. PilF contains a C-terminal ATPase domain and three N-terminal domains with...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-019-09911-z
更新日期:2019-10-01 00:00:00
abstract::Early response to dehydration 10 protein (ERD10) is an intrinsically disordered protein from Arabidopsis thaliana. The protein is upregulated during stress however its mechanism of action at atomic level is not well understood. In the present work multidimensional NMR methodologies are used in order to facilitate the ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-017-9732-0
更新日期:2017-10-01 00:00:00
abstract::X-linked inhibitor of apoptosis protein (XIAP), a leading member of the family of inhibitor of apoptosis (IAP) proteins, is considered as the most potent and versatile inhibitor of caspases and apoptosis. It has been reported that XIAP is frequently overexpressed in cancer and its expression level is implicated in con...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-009-9197-x
更新日期:2010-04-01 00:00:00
abstract::The C-terminally truncated Y145Stop variant of prion protein (PrP23-144) has been linked to a heritable prionopathy in humans and is also capable of triggering a transmissible prion disease in mice. PrP23-144 can be converted from soluble monomeric form to amyloid under physiological conditions, providing an in vitro ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-020-09981-4
更新日期:2020-10-29 00:00:00
abstract::The homeobox gene (HOXA13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of many important proteins during embryonic morphogenesis. We report complete NMR chemical shift assignments of the mouse HOXA13 DNA binding domain (A13DBD; BMRB no. 16252). ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-009-9174-4
更新日期:2009-12-01 00:00:00
abstract::The 19.9 kDa C-terminal module (R3) from Azotobacter vinelandii mannronan C5-epimerase AlgE6 has been (13)C, (15)N isotopically labelled and recombinantly expressed. We report here the (1)H, (13)C, (15)N resonance assignment of AlgE6R3. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9259-0
更新日期:2011-04-01 00:00:00
abstract::The Breast Cancer susceptibility protein 2 (BRCA2) is involved in mechanisms that maintain genome stability, including DNA repair, replication and cell division. These functions are ensured by the folded C-terminal DNA binding domain of BRCA2 but also by its large regions predicted to be disordered. Several studies ha...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-019-09924-8
更新日期:2020-04-01 00:00:00
abstract::We present the backbone and sidechain NMR assignments and a structural analysis of the 178-residue wild-type γS-crystallin and the cataract-related point mutant, γS-G18V. γS-crystallin is a structural component of the eye lens, which maintains its solubility and stability over many years. NMR assignments and continued...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-011-9326-1
更新日期:2012-04-01 00:00:00
abstract::The catalytic subunit of protein kinase A is involved with a number of signal transduction pathways and has been used as a benchmark to study the structural biology and biochemistry for the entire kinase family of enzymes. Here, we report the backbone assignment of the intact 41 kDa catalytic subunit bound to AMP-PNP....
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-009-9154-8
更新日期:2009-06-01 00:00:00
abstract::LicT belongs to an essential family of bacterial antitermination proteins which bind to nascent mRNAs in order to stimulate transcription of sugar-metabolizing operons. As most of other antitermination proteins involved in carbohydrate metabolism, LicT is composed of a N-terminal RNA-binding module (CAT) and two homol...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-019-09914-w
更新日期:2020-04-01 00:00:00
abstract::The apo-form of the 21.4 kDa catalytic domain and the 10.7 kDa carbohydrate binding domain of the AA10 family lytic polysaccharide monooxygenase ScLPMO10C from Streptomyces coelicolor have been isotopically labeled and recombinantly expressed in Escherichia coli. In this paper, we report the 1H, 13C, and 15N chemical ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-017-9759-2
更新日期:2017-10-01 00:00:00
abstract::YbeA is a 3-methylpseudoridine methyltransferase from Escherichia coli that forms a stable homodimer in solution. It is one of the deeply trefoil 31 knotted proteins, of which the knot encompasses the C-terminal helix that threads through a long loop. Recent studies on the knotted protein folding pathways using YbeA h...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-013-9501-7
更新日期:2014-10-01 00:00:00
abstract::Sulfolobus solfataricus DNA polymerase IV (Dpo4), a prototype Y-family DNA polymerase, contains a unique little finger domain besides a catalytic core. Here, we report the chemical shift assignments for the backbone nitrogens, α and β carbons, and amide protons of the little finger domain of Dpo4. This work and our pu...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-011-9298-1
更新日期:2011-10-01 00:00:00
abstract::The peptidoglycan is a major component of the bacterial cell wall and is essential to maintain cellular integrity and cell shape. Penicillin-Binding Proteins (PBPs) catalyze the final biosynthetic steps of peptidoglycan synthesis from lipid II precursor and are the main targets of β-lactam antibiotics. The molecular d...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-014-9546-2
更新日期:2015-04-01 00:00:00
abstract::Plasmodium falciparum is responsible for causing cerebral malaria in humans. IMP1 is an immunogenic protein, present in the parasite, which has been shown to induce an immune response against apicomplexan parasites in a species-specific manner. Here, we report the complete NMR assignments of PfIMP1. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-015-9616-0
更新日期:2015-10-01 00:00:00
abstract::In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-018-9864-x
更新日期:2019-04-01 00:00:00
abstract::Heterogeneous nuclear ribonucleoproteins (hnRNPs) can be divided into subgroups based on their RNA-binding characteristics. One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or α-complex proteins (α-CP) 1-4]. Each subgroup ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-015-9624-0
更新日期:2015-10-01 00:00:00
abstract::Phosphoethanolamine methyltransferases (PMTs also known as PEAMTs) catalyze the three-step s-adenosyl-methionione-dependent methylation of phosphoethanolamine to form phosphocholine. These enzymes play an important function in the synthesis of phosphatidylcholine, the major phospholipid in the membranes of lower and h...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-012-9372-3
更新日期:2013-04-01 00:00:00
abstract::PRK1 is a member of the protein kinase C-related kinase (PRK) family of serine/threonine kinases and a downstream effector of Rho GTPases. PRK1 has three N-terminal Homology Region 1 (HR1) domains (HR1a, HR1b and HR1c), which form antiparallel coiled coils that interact with Rho family GTPases. PRK1 also has a C2-like...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-020-09954-7
更新日期:2020-10-01 00:00:00
abstract::We report almost complete sequence specific 1H, 13C and 15N NMR assignments of a 151-residue long calmodulin-like calcium-binding protein from Entamoeba histolytica (EhCaM). ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-008-9089-5
更新日期:2008-06-01 00:00:00