Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib.

abstract：:The protein dimethyladenosine transferase 1 (Dim1) is a highly conserved protein occurring in organisms ranging from bacteria such as E. coli where it is named KsgA to humans. Since Dim1 is involved in the biogenesis of the small ribosomal subunit it is an essential protein. During ribosome biogenesis Dim1 acts as an ...

journal_title：Biomolecular NMR assignments

authors： Kaiser M,Hacker C,Duchardt-Ferner E,Wöhnert J

更新日期：2019-10-01 00:00:00

abstract：:S100A15 (koebnerisin) is overexpressed in psoriatic skin and displays distinct localizations in skin and breast with divergent functions in inflammation. Here we report the backbone and side-chain resonance assignments for the Ca(2+)-bound human S100A15. ...

journal_title：Biomolecular NMR assignments

authors： Cho CC,Hung KW,Yu C

更新日期：2014-04-01 00:00:00

abstract：:Hsp70 chaperone proteins play crucial roles in the cell. Extensive structural and functional studies have been performed for bacterial and mammalian Hsp70s. Ssa1 from Saccharomyces cerevisiae is a member of the Hsp70 family. In vivo and biochemical studies on Ssa1 have revealed that it regulates prion propagation and ...

journal_title：Biomolecular NMR assignments

authors： Hu W,Wu H,Zhang H,Gong W,Perrett S

更新日期：2015-10-01 00:00:00

abstract：:TraI, the F plasmid-encoded nickase, is a 1,756 amino acid protein essential for conjugative transfer of F plasmid DNA from one bacterium to another. While crystal structures of N- and C-terminal domains of F TraI have been determined, central domains of the protein are structurally unexplored. These middle domains (b...

journal_title：Biomolecular NMR assignments

authors： Wright NT,Majumdar A,Schildbach JF

更新日期：2011-04-01 00:00:00

abstract：:Latent TGFβ binding protein 1 (LTBP1) is a large extracellular protein that has been shown to bind covalently to the propeptide of TGFβ cytokines and form a large latent complex, which is then incapable of binding TGFβ receptors. LTBP1 has also been demonstrated to interact with a number of insoluble extracellular mat...

journal_title：Biomolecular NMR assignments

authors： Robertson IB,Handford PA,Redfield C

更新日期：2014-04-01 00:00:00

abstract：:RpsA, also known as ribosomal protein S1, is an essential protein required for translation initiation of mRNAs when their Shine-Dalgarno sequence is degenerated (Sorensen et al. 1998). In addition, RpsA of Mycobacterium tuberculosis (M. tb) is involved in trans-translation, which is an effective system mediated by tmR...

journal_title：Biomolecular NMR assignments

authors： Fu J,Huang B,Lin D,Liao X

更新日期：2017-10-01 00:00:00

abstract：:TAR RNA binding protein (TRBP) is a double-stranded RNA binding protein involved in various biological processes like cell growth, development, death, etc. The protein exists as two isoforms TRBP2 and TRBP1. TRBP2 contains additional 21 amino acids at its N-terminus, which are proposed to be involved in its membrane l...

journal_title：Biomolecular NMR assignments

authors： Paithankar H,Jadhav PV,Naglekar AS,Sharma S,Chugh J

更新日期：2018-04-01 00:00:00

abstract：:The archaeal protein L7Ae forms part of a protein complex in the ribosome that specifically recognizes and binds to kink-turn RNA. In this complex, L7Ae directly interacts with the oligonucleotide and creates a functional arrangement for site-specific 2'-O-methylation. We report the solution NMR backbone assignment of...

journal_title：Biomolecular NMR assignments

authors： Moschen T,Wunderlich C,Kreutz C,Tollinger M

更新日期：2015-04-01 00:00:00

abstract：:The C-terminally truncated Y145Stop variant of prion protein (PrP23-144) has been linked to a heritable prionopathy in humans and is also capable of triggering a transmissible prion disease in mice. PrP23-144 can be converted from soluble monomeric form to amyloid under physiological conditions, providing an in vitro ...

journal_title：Biomolecular NMR assignments

authors： Dao HH,Hlaing MZ,Ma Y,Surewicz K,Surewicz WK,Jaroniec CP

更新日期：2020-10-29 00:00:00

abstract：:Human voltage-gated sodium (NaV) channels are critical for initiating and propagating action potentials in excitable cells. Nine isoforms have different roles but similar topologies, with a pore-forming α-subunit and auxiliary transmembrane β-subunits. NaV pathologies lead to debilitating conditions including epilepsy...

journal_title：Biomolecular NMR assignments

authors： Isbell HM,Kilpatrick AM,Lin Z,Mahling R,Shea MA

更新日期：2018-10-01 00:00:00

abstract：:The S100 family belongs to the EF-hand calcium-binding proteins regulating a wide range of important cellular processes via protein-protein interactions. Most S100 proteins adopt a conformation of non-covalent homodimer for their functions. Calcium binding to the EF-hand motifs of S100 proteins is essential for trigge...

journal_title：Biomolecular NMR assignments

authors： Hung KW,Chang YM,Yu C

更新日期：2013-10-01 00:00:00

abstract：:We report here the resonance assignment of EDK-∆-Bd37, conformational mutant potentially displaying the "open" conformation of Bd37, a 25 kDa surface protein from the Apicomplexa parasite Babesia divergens that could undergo drastic conformational changes during erythrocyte invasion. ...

journal_title：Biomolecular NMR assignments

authors： Barthe P,Murciano B,Schetters T,Gorenflot A,Delbecq S,Roumestand C

更新日期：2013-10-01 00:00:00

abstract：:Human heterogeneous nuclear ribonucleoprotein H (hnRNP H) regulates alternative splicing of HIV-1 Tat pre-mRNA. The structure of the first N-terminal domain (residues 1-104) of hnRNP H was solved and its binding to an exonic splicing silencer (pESS2) studied. For this, all backbone and 85% of side-chain resonance freq...

journal_title：Biomolecular NMR assignments

authors： Cabal S,van Heijenoort C,Guittet E

更新日期：2007-12-01 00:00:00

abstract：:Phosphoenolpyruvate binding to the C-terminal domain (EIC) of enzyme I of the bacterial phosphotransferase system (PTS) initiates a phosphorylation cascade that results in sugar translocation across the cell membrane and controls a large number of essential pathways in bacterial metabolism. EIC undergoes an expanded t...

journal_title：Biomolecular NMR assignments

authors： Dotas RR,Venditti V

更新日期：2018-04-01 00:00:00

abstract：:The 19.9 kDa C-terminal module (R3) from Azotobacter vinelandii mannronan C5-epimerase AlgE6 has been (13)C, (15)N isotopically labelled and recombinantly expressed. We report here the (1)H, (13)C, (15)N resonance assignment of AlgE6R3. ...

journal_title：Biomolecular NMR assignments

authors： Buchinger E,Skjåk-Bræk G,Valla S,Wimmer R,Aachmann FL

更新日期：2011-04-01 00:00:00

abstract：:Phosphoethanolamine methyltransferases (PMTs also known as PEAMTs) catalyze the three-step s-adenosyl-methionione-dependent methylation of phosphoethanolamine to form phosphocholine. These enzymes play an important function in the synthesis of phosphatidylcholine, the major phospholipid in the membranes of lower and h...

journal_title：Biomolecular NMR assignments

authors： Bezsonova I,Rujan I,Bobenchik AM,Gorbatyuk V,Maciejewski MW,Gorbatyuk O,Hao B,Arthanari H,Mamoun CB,Hoch JC

更新日期：2013-04-01 00:00:00

abstract：:Tuberculosis is one of the deadliest diseases worldwide affecting approximately 10 million people in 2018. This classifies tuberculosis as epidemic in several countries and leads to an increasing number of multidrug-resistant strains. Thus, the development of new drugs is essential to effective treatments. A potential...

journal_title：Biomolecular NMR assignments

authors： Bartkevihi L,Martins B,de Oliveira DMP,Pires JRM,Anobom CD,Almeida FCL

更新日期：2020-04-01 00:00:00

abstract：:PRK1 is a member of the protein kinase C-related kinase (PRK) family of serine/threonine kinases and a downstream effector of Rho GTPases. PRK1 has three N-terminal Homology Region 1 (HR1) domains (HR1a, HR1b and HR1c), which form antiparallel coiled coils that interact with Rho family GTPases. PRK1 also has a C2-like...

journal_title：Biomolecular NMR assignments

authors： Sophocleous G,Wood G,Owen D,Mott HR

更新日期：2020-10-01 00:00:00

abstract：:Light chain (AL) amyloidosis is a systemic disease characterized by the formation of immunoglobulin light-chain fibrils in critical organs of the body. The light-chain protein AL-09 presents one severe case of cardiac AL amyloidosis, which contains seven mutations in the variable domain (VL) relative to its germline c...

journal_title：Biomolecular NMR assignments

authors： Piehl DW,Blancas-Mejía LM,Ramirez-Alvarado M,Rienstra CM

更新日期：2017-04-01 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) 4 has been associated with progression of melanoma, breast, head and neck and hepatocellular carcinoma and is therefore an interesting target for therapeutic intervention (Ho et al. in J Hepatol 50:118-127, 2009). The extracellular D2 domain of the FGFR4 receptor contains a hep...

journal_title：Biomolecular NMR assignments

authors： Elshorst B,Saxena K,Schieborr U,Schwalbe H

更新日期：2013-10-01 00:00:00

abstract：:In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 ...

journal_title：Biomolecular NMR assignments

authors： Ahammer L,Grutsch S,Wallner M,Ferreira F,Tollinger M

更新日期：2017-10-01 00:00:00

abstract：:The gelation factor from Dictyostelium discoideum (ABP-120) is an actin binding protein consisting of six immunoglobulin (Ig) domains in the C-terminal rod domain. We have recently used the pair of domains 5 and 6 of ABP-120 as a model system for studying multi-domain nascent chain folding on the ribosome. Here we pre...

journal_title：Biomolecular NMR assignments

authors： Hsu ST,Cabrita LD,Christodoulou J,Dobson CM

更新日期：2009-06-01 00:00:00

abstract：:In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic ...

journal_title：Biomolecular NMR assignments

authors： Führer S,Trimmel S,Breuker K,Tollinger M

更新日期：2019-04-01 00:00:00

abstract：:Myeloid differentiating factor 88 (MyD88) is one of a critical adaptor molecule in the Toll-like receptor (TLR) signaling pathway. The TIR domain of MyD88 serves as a protein-protein interaction module and interacts with other TIR-containing proteins such as Mal (MyD88 adaptor-like) and Toll-like receptor 4 to form si...

journal_title：Biomolecular NMR assignments

authors： Ohnishi H,Tochio H,Kato Z,Kimura T,Hiroaki H,Kondo N,Shirakawa M

更新日期：2010-10-01 00:00:00

abstract：:The replication of the hepatitis B virus is initiated by binding of the viral reverse transcriptase protein complex to the apical stem loop of the epsilon element to place it next to the primer loop, from which a four nucleotide DNA primer is subsequently synthesized. Here, we present the (1)H/(13)C/(15)N NMR assignme...

journal_title：Biomolecular NMR assignments

authors： van der Werf RM,Girard FC,Nelissen F,Tessari M,Wijmenga SS

更新日期：2008-12-01 00:00:00

abstract：:NOXO1 (Nox Organizer 1) is a homolog of the NAPDH oxidase protein p47(phox). NADPH oxidases transfer electrons from NADPH to molecular oxygen, generating the superoxide anion. NOXO1 contains an N-terminal PX (phox homology) domain and is one of several PX domain-containing proteins found in the cytosolic subunits of t...

journal_title：Biomolecular NMR assignments

authors： Davis NY,McPhail LC,Horita DA

更新日期：2011-10-01 00:00:00

abstract：:Norovirus protease cleaves the virus-encoded polyprotein into six mature nonstructural proteins, presenting itself as an essential enzyme for the viral replication as well as an attractive target for the antiviral drug development. A deeper understanding of the structural mechanism of the protease-substrates/inhibitor...

journal_title：Biomolecular NMR assignments

authors： Takahashi D,Kim Y,Chang KO,Anbanandam A,Prakash O

更新日期：2012-04-01 00:00:00

abstract：:We present the backbone and sidechain NMR assignments and a structural analysis of the 178-residue wild-type γS-crystallin and the cataract-related point mutant, γS-G18V. γS-crystallin is a structural component of the eye lens, which maintains its solubility and stability over many years. NMR assignments and continued...

journal_title：Biomolecular NMR assignments

authors： Brubaker WD,Martin RW

更新日期：2012-04-01 00:00:00

abstract：:We report NMR assignments of the protein backbone of the C-terminal domain (163 a.a.) of human class 1 translation termination factor eRF1. It was found that several protein loop residues exist in two slowly interconverting conformational states. ...

journal_title：Biomolecular NMR assignments

authors： Mantsyzov AB,Ivanova EV,Birdsall B,Kolosov PM,Kisselev LL,Polshakov VI

更新日期：2007-12-01 00:00:00

abstract：:FK506 Binding Proteins (FKBPs) are a family of highly conserved and important proteins that possess a peptidyl cis-trans isomerase (PPIases) domain. Human FKBP12 is a prototype of this family and it is involved in many diseases due to its interaction with the immunosuppressive drugs FK506 and rapamycin. They inhibit c...

journal_title：Biomolecular NMR assignments

authors： Andrade GC,Silva LFC,Oliveira DMP,Pires JRM,Almeida FCL,Anobom CD

更新日期：2019-04-01 00:00:00