Abstract:
:Fibroblast growth factor receptor (FGFR) 4 has been associated with progression of melanoma, breast, head and neck and hepatocellular carcinoma and is therefore an interesting target for therapeutic intervention (Ho et al. in J Hepatol 50:118-127, 2009). The extracellular D2 domain of the FGFR4 receptor contains a heparin binding site and the main interaction site with the fibroblast growth factor. We report the sequential backbone and side chain resonance assignment of the D2 domain of human FGFR4.
journal_name
Biomol NMR Assignjournal_title
Biomolecular NMR assignmentsauthors
Elshorst B,Saxena K,Schieborr U,Schwalbe Hdoi
10.1007/s12104-012-9405-ysubject
Has Abstractpub_date
2013-10-01 00:00:00pages
179-82issue
2eissn
1874-2718issn
1874-270Xjournal_volume
7pub_type
杂志文章abstract::We report the (1)H, (13)C, and (15)N chemical shift assignments of both oxidized and reduced forms of an abundant periplasmic c-type cytochrome, designated ApcA, isolated from the acidophilic gram-negative facultatively anaerobic metal-reducing alphaproteobacterium Acidiphilium cryptum. These resonance assignments pro...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9274-1
更新日期:2011-04-01 00:00:00
abstract::The catalytic subunit of protein kinase A is involved with a number of signal transduction pathways and has been used as a benchmark to study the structural biology and biochemistry for the entire kinase family of enzymes. Here, we report the backbone assignment of the intact 41 kDa catalytic subunit bound to AMP-PNP....
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-009-9154-8
更新日期:2009-06-01 00:00:00
abstract::FK506 Binding Proteins (FKBPs) are a family of highly conserved and important proteins that possess a peptidyl cis-trans isomerase (PPIases) domain. Human FKBP12 is a prototype of this family and it is involved in many diseases due to its interaction with the immunosuppressive drugs FK506 and rapamycin. They inhibit c...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-019-09884-z
更新日期:2019-04-01 00:00:00
abstract::Chromatin remodelling proteins are an essential family of eukaryotic proteins. They harness the energy from ATP hydrolysis and apply it to alter chromatin structure in order to regulate all aspects of genome biology. Chromodomain helicase DNA-binding protein 1 (CHD1) is one such remodelling protein that has specialise...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-015-9631-1
更新日期:2016-04-01 00:00:00
abstract::Snu13p is a highly conserved RNA binding protein from Saccharomyces cerevisiae required for both eukaryotic pre-mRNA splicing and pre-rRNA processing. The 1H, 13C, and 15N assignments were determined from multidimensional, multinuclear NMR experiments conducted at 25 degrees C. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-007-9069-1
更新日期:2008-06-01 00:00:00
abstract::Nearly complete backbone resonance assignments for the 357 residue, 42 kDa enzyme arginine kinase in a transition state analogue (TSA) complex are presented. The TSA is a quaternary complex of arginine kinase, MgADP, arginine, and nitrate. About 93% (320 of 344) of the non-proline backbone amides were assigned using a...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-013-9512-4
更新日期:2014-10-01 00:00:00
abstract::Norovirus protease cleaves the virus-encoded polyprotein into six mature nonstructural proteins, presenting itself as an essential enzyme for the viral replication as well as an attractive target for the antiviral drug development. A deeper understanding of the structural mechanism of the protease-substrates/inhibitor...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-011-9316-3
更新日期:2012-04-01 00:00:00
abstract::A hemolymph juvenile hormone binding protein (JHBP) shuttles hydrophobic JH, a key hormone in regulation of the insect life cycle, from the site of the JH biosynthesis to the cells of target organs. We report complete NMR chemical shift assignments of Bombyx mori JHBP in the JH III-bound state. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-009-9144-x
更新日期:2009-06-01 00:00:00
abstract::Hsp70 chaperone proteins play crucial roles in the cell. Extensive structural and functional studies have been performed for bacterial and mammalian Hsp70s. Ssa1 from Saccharomyces cerevisiae is a member of the Hsp70 family. In vivo and biochemical studies on Ssa1 have revealed that it regulates prion propagation and ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-015-9603-5
更新日期:2015-10-01 00:00:00
abstract::The actin filament dynamics in nematode, Caenorhabditis elegans, is regulated by differential activity of two proteins UNC-60A and UNC-60B. UNC-60A exhibits strong pointed end depolymerization on C. elegans actin (Ce-actin), strong inhibition of polymerization, strong monomer sequestering activity, weak severing activ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-014-9588-5
更新日期:2015-10-01 00:00:00
abstract::The agglutinin-like-sequence (ALS) family of adhesion proteins are a key virulence factor for C. albicans. These proteins have been implicated in several functions, notably adhesion and invasion of different cell types, as well as binding to peptides and proteins in the cell surface and extracellular matrix. In order ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9243-8
更新日期:2010-10-01 00:00:00
abstract::In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-017-9754-7
更新日期:2017-10-01 00:00:00
abstract::A peptide or a small protein released from an exocrine gland or in urine is utilized as a chemosignal that elicits social or reproductive behavior in mice. Recently, we identified the male-specific peptide, exocrine gland-secreting peptide 1 (ESP1), in mouse tear fluids that enhanced female sexual receptive behavior, ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-012-9441-7
更新日期:2014-04-01 00:00:00
abstract::Galectins recognize β-galectosides to promote a variety of cellular functions. Despite their sequence variations, all galectins share the same carbohydrate recognition domains (CRD) and their modes of ligand recognition at a structural level are essentially identical. Human galectin 8 plays an important role in numero...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-015-9623-1
更新日期:2015-10-01 00:00:00
abstract::Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen and a primary cause of infection in humans. P. aeruginosa can acquire resistance against multiple groups of antimicrobial agents, including β-lactams, aminoglycosides and fluoroquinolones, and multidrug resistance is increasing in this organism which mak...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-016-9678-7
更新日期:2016-10-01 00:00:00
abstract::GNA2132 (Genome-derived Neisseria Antigen 2132) is a surface-exposed lipoprotein discovered by reverse vaccinology and expressed by genetically diverse Neisseria meningitidis strains (Pizza et al. 2000). The protein induces bactericidal antibodies against most strains of Meningococccus and has been included in a multi...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9220-2
更新日期:2010-04-01 00:00:00
abstract::PTPN5 is a protein tyrosine phosphatase that plays an integral role in regulating excitatory postsynaptic activity. The sequence-specific backbone assignments of the murine PTPN5 catalytic domain have been determined based on triple-resonance experiments using uniformly [(2)H,(13)C,(15)N]-labeled protein. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-013-9480-8
更新日期:2014-04-01 00:00:00
abstract::RegB is involved in the control of the phage T4 life cycle. It inactivates the phage early mRNAs when their translation is no more required. We determined its structure and identified residues involved in substrate binding. For this, all backbone and 90% of side-chain resonance frequencies were assigned. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-007-9021-4
更新日期:2007-07-01 00:00:00
abstract::The 19.9 kDa C-terminal module (R3) from Azotobacter vinelandii mannronan C5-epimerase AlgE6 has been (13)C, (15)N isotopically labelled and recombinantly expressed. We report here the (1)H, (13)C, (15)N resonance assignment of AlgE6R3. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9259-0
更新日期:2011-04-01 00:00:00
abstract::The gelation factor from Dictyostelium discoideum (ABP-120) is an actin binding protein consisting of six immunoglobulin (Ig) domains in the C-terminal rod domain. We have recently used the pair of domains 5 and 6 of ABP-120 as a model system for studying multi-domain nascent chain folding on the ribosome. Here we pre...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-008-9134-4
更新日期:2009-06-01 00:00:00
abstract::Early response to dehydration 10 protein (ERD10) is an intrinsically disordered protein from Arabidopsis thaliana. The protein is upregulated during stress however its mechanism of action at atomic level is not well understood. In the present work multidimensional NMR methodologies are used in order to facilitate the ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-017-9732-0
更新日期:2017-10-01 00:00:00
abstract::Immunoglobulin E (IgE) plays a central role in allergic reactions. IgE is a dynamic molecule that is capable of undergoing large conformational changes. X-ray crystal structures of the Fc region of IgE in complex with various ligands have shown that IgE-Fc can exist in extended and various bent conformations. IgE-Fc c...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-020-09936-9
更新日期:2020-04-01 00:00:00
abstract::TraI, the F plasmid-encoded nickase, is a 1,756 amino acid protein essential for conjugative transfer of F plasmid DNA from one bacterium to another. While crystal structures of N- and C-terminal domains of F TraI have been determined, central domains of the protein are structurally unexplored. These middle domains (b...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-010-9269-y
更新日期:2011-04-01 00:00:00
abstract::Q38FZ4 (UniProt accession number), is an 85-residue hypothetical protein from Trypanosoma brucei (T. brucei). Q38FZ4, which might be specific among the trypanosomatid genomes, shares low sequence similarity with mammal proteins and also has an essential function in the growth of T. brucei. Here we report the resonance...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-020-09956-5
更新日期:2020-10-01 00:00:00
abstract::The S100 family belongs to the EF-hand calcium-binding proteins regulating a wide range of important cellular processes via protein-protein interactions. Most S100 proteins adopt a conformation of non-covalent homodimer for their functions. Calcium binding to the EF-hand motifs of S100 proteins is essential for trigge...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-012-9412-z
更新日期:2013-10-01 00:00:00
abstract::A pheromone-binding protein from navel orange worm, Amyelois transitella (Atra-PBP1) binds to non-polar pheromone molecules and facilitates the transport and delivery of pheromone to the membrane-bound pheromone receptors. We report complete NMR chemical shift assignments of Atra-PBP1 obtained at pH 4.5 and 25 degrees...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-008-9096-6
更新日期:2008-12-01 00:00:00
abstract::Translationally-controlled tumor protein (TCTP) is a eukaryote-conserved protein with crucial roles in cellular growth. It has also been proposed that plant TCTP has functions specific to plant, while no structure of TCTP from photosynthetic organism has been reported. Nannochloropsis is a photosynthetic microalga wit...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-015-9602-6
更新日期:2015-10-01 00:00:00
abstract::Cohesin and dockerin domains are critical assembling components of cellulosome, a large extracellular multienzyme complex which is used by anaerobic cellulolytic bacteria to efficiently degrade lignocellulose. According to sequence homology, cohesins can be divided into three major groups, whereas cohesins from Clostr...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-012-9381-2
更新日期:2013-04-01 00:00:00
abstract::S100A15 (koebnerisin) is overexpressed in psoriatic skin and displays distinct localizations in skin and breast with divergent functions in inflammation. Here we report the backbone and side-chain resonance assignments for the Ca(2+)-bound human S100A15. ...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-013-9476-4
更新日期:2014-04-01 00:00:00
abstract::Light chain (AL) amyloidosis is a systemic disease characterized by the formation of immunoglobulin light-chain fibrils in critical organs of the body. The light-chain protein AL-09 presents one severe case of cardiac AL amyloidosis, which contains seven mutations in the variable domain (VL) relative to its germline c...
journal_title:Biomolecular NMR assignments
pub_type: 杂志文章
doi:10.1007/s12104-016-9718-3
更新日期:2017-04-01 00:00:00