1H, 13C, 15N backbone NMR resonance assignments for the rRNA methyltransferase Dim1 from the hyperthermophilic archaeon Pyrococcus horikoshii.

abstract：:PRK1 is a member of the protein kinase C-related kinase (PRK) family of serine/threonine kinases and a downstream effector of Rho GTPases. PRK1 has three N-terminal Homology Region 1 (HR1) domains (HR1a, HR1b and HR1c), which form antiparallel coiled coils that interact with Rho family GTPases. PRK1 also has a C2-like...

journal_title：Biomolecular NMR assignments

authors： Sophocleous G,Wood G,Owen D,Mott HR

更新日期：2020-10-01 00:00:00

abstract：:Galectins recognize β-galectosides to promote a variety of cellular functions. Despite their sequence variations, all galectins share the same carbohydrate recognition domains (CRD) and their modes of ligand recognition at a structural level are essentially identical. Human galectin 8 plays an important role in numero...

journal_title：Biomolecular NMR assignments

authors： Liu CH,Chien CT,Lin CH,Hsu ST

更新日期：2015-10-01 00:00:00

abstract：:The cDNA of UVI31+ was cloned from C. reinhardtii and expressed in E. coli from where the protein was purified to homogeneity. The purified protein exhibited beta-lactamase activity (Manuscript in preparation). However, UVI31+ has no homology with the known β-lactamases. In order to understand the structural basis of ...

journal_title：Biomolecular NMR assignments

authors： Rout AK,Minda R,Peri D,Ramakrishnan V,Bhattacharjee SK,Rao BJ,Chary KV

更新日期：2010-10-01 00:00:00

abstract：:In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the 17.5 kDa major birch pollen allergen Bet v 1, which belongs to the family of PR-10 (pathogenesis-related) proteins. In nature, Bet v 1 ...

journal_title：Biomolecular NMR assignments

authors： Ahammer L,Grutsch S,Wallner M,Ferreira F,Tollinger M

更新日期：2017-10-01 00:00:00

abstract：:Ras homologue enriched in brain (Rheb) is a small GTPase that plays an important role in tuberous sclerosis. Here we present the backbone assignments of activated rRheb in complex with the non-hydrolisable GTP analogue GppNHp. These assignments now provide a basis for the analysis of rRheb's interaction with putative ...

journal_title：Biomolecular NMR assignments

authors： Schwarten M,Berghaus C,Heumann R,Stoll R

更新日期：2007-07-01 00:00:00

abstract：:The catalytic subunit of protein kinase A is involved with a number of signal transduction pathways and has been used as a benchmark to study the structural biology and biochemistry for the entire kinase family of enzymes. Here, we report the backbone assignment of the intact 41 kDa catalytic subunit bound to AMP-PNP....

journal_title：Biomolecular NMR assignments

authors： Masterson LR,Shi L,Tonelli M,Mascioni A,Mueller MM,Veglia G

更新日期：2009-06-01 00:00:00

abstract：:Nervous necrosis virus (NNV) is a non-enveloped virus that causes massive mortality in aquaculture fish production worldwide. Recently X-ray crystallography and single particle cryo-EM have independently determined the icosahedral capsid of NNV to near-atomic resolutions to show the capsid protein is composed of a S-d...

journal_title：Biomolecular NMR assignments

authors： Štěrbová P,Wu D,Lou YC,Wang CH,Chang WH,Tzou DM

更新日期：2020-04-01 00:00:00

abstract：:Myeloid differentiating factor 88 (MyD88) is one of a critical adaptor molecule in the Toll-like receptor (TLR) signaling pathway. The TIR domain of MyD88 serves as a protein-protein interaction module and interacts with other TIR-containing proteins such as Mal (MyD88 adaptor-like) and Toll-like receptor 4 to form si...

journal_title：Biomolecular NMR assignments

authors： Ohnishi H,Tochio H,Kato Z,Kimura T,Hiroaki H,Kondo N,Shirakawa M

更新日期：2010-10-01 00:00:00

abstract：:Immunoglobulin E (IgE) plays a central role in allergic reactions. IgE is a dynamic molecule that is capable of undergoing large conformational changes. X-ray crystal structures of the Fc region of IgE in complex with various ligands have shown that IgE-Fc can exist in extended and various bent conformations. IgE-Fc c...

journal_title：Biomolecular NMR assignments

authors： Benjamin SV,Creeke PI,Henry AJ,McDonnell JM

更新日期：2020-04-01 00:00:00

abstract：:We report NMR assignments of the protein backbone of the C-terminal domain (163 a.a.) of human class 1 translation termination factor eRF1. It was found that several protein loop residues exist in two slowly interconverting conformational states. ...

journal_title：Biomolecular NMR assignments

authors： Mantsyzov AB,Ivanova EV,Birdsall B,Kolosov PM,Kisselev LL,Polshakov VI

更新日期：2007-12-01 00:00:00

abstract：:Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib. ...

journal_title：Biomolecular NMR assignments

authors： Vajpai N,Strauss A,Fendrich G,Cowan-Jacob SW,Manley PW,Jahnke W,Grzesiek S

更新日期：2008-06-01 00:00:00

abstract：:Bacillus subtilis ATCC 6633 produces the lipid II targeting lantibiotic subtilin. For self-protection these gram-positive bacteria express a cluster of four self-immunity proteins named SpaIFEG. SpaI is a 16.8 kDa lipoprotein which is attached to the outside of the cytoplasmic membrane via a covalently linked diacylgl...

journal_title：Biomolecular NMR assignments

authors： Christ NA,Duchardt-Ferner E,Düsterhus S,Kötter P,Entian KD,Wöhnert J

更新日期：2012-04-01 00:00:00

abstract：:During its life cycle, the malaria parasite Plasmodium falciparum is found intracellular to human erythrocytes, where its survival and ability to multiply critically depends on the control of the environment redox state. Thioredoxin is a small protein containing 104 amino acids that is part of the parasite specific re...

journal_title：Biomolecular NMR assignments

authors： Munte CE,Becker K,Schirmer RH,Kalbitzer HR

更新日期：2009-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease, where dopaminergic cells die most prominently in the area of substantia nigra. Neurotrophic factors (NTFs) are secreted proteins, which upon binding to their target receptors trigger survival pathways to prevent neuronal loss. Recently disco...

journal_title：Biomolecular NMR assignments

authors： Hellman M,Peränen J,Saarma M,Permi P

更新日期：2010-10-01 00:00:00

abstract：:Heterogeneous nuclear ribonucleoproteins (hnRNPs) can be divided into subgroups based on their RNA-binding characteristics. One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of hnRNP K/J and hnRNP E1-4 [the latter also known as PCBP 1-4 or α-complex proteins (α-CP) 1-4]. Each subgroup ...

journal_title：Biomolecular NMR assignments

authors： Li Y,Hennig M

更新日期：2015-10-01 00:00:00

abstract：:The peptidoglycan is a major component of the bacterial cell wall and is essential to maintain cellular integrity and cell shape. Penicillin-Binding Proteins (PBPs) catalyze the final biosynthetic steps of peptidoglycan synthesis from lipid II precursor and are the main targets of β-lactam antibiotics. The molecular d...

journal_title：Biomolecular NMR assignments

authors： Jean NL,Bougault C,Derouaux A,Callens G,Vollmer W,Simorre JP

更新日期：2015-04-01 00:00:00

abstract：:Salmonella typhimurium OppA is the periplasmic oligopeptide-binding protein. Backbone resonances of OppA(D419N) on its own were assigned for approximately 90% of residues. Missing residues are localised around the ligand-binding site, suggesting conformational flexibility in the unliganded state. ...

journal_title：Biomolecular NMR assignments

authors： Kurashima-Ito K,Moromisato K,Nishimura K,Wälchli M,Tame JR,Ito Y

更新日期：2007-07-01 00:00:00

abstract：:YbeA is a 3-methylpseudoridine methyltransferase from Escherichia coli that forms a stable homodimer in solution. It is one of the deeply trefoil 31 knotted proteins, of which the knot encompasses the C-terminal helix that threads through a long loop. Recent studies on the knotted protein folding pathways using YbeA h...

journal_title：Biomolecular NMR assignments

authors： Hsieh SJ,Mallam AL,Jackson SE,Hsu ST

更新日期：2014-10-01 00:00:00

abstract：:Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen and a primary cause of infection in humans. P. aeruginosa can acquire resistance against multiple groups of antimicrobial agents, including β-lactams, aminoglycosides and fluoroquinolones, and multidrug resistance is increasing in this organism which mak...

journal_title：Biomolecular NMR assignments

authors： Bernal A,Hu Y,Palmer SO,Silva A,Bullard J,Zhang Y

更新日期：2016-10-01 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) 4 has been associated with progression of melanoma, breast, head and neck and hepatocellular carcinoma and is therefore an interesting target for therapeutic intervention (Ho et al. in J Hepatol 50:118-127, 2009). The extracellular D2 domain of the FGFR4 receptor contains a hep...

journal_title：Biomolecular NMR assignments

authors： Elshorst B,Saxena K,Schieborr U,Schwalbe H

更新日期：2013-10-01 00:00:00

abstract：:Ubiquitin Specific Protease 25 (USP25), a member of the deubiquitinase family, is involved in several disease-related signal pathways including myogenesis, immunity and protein degradation. It specially catalyzes the hydrolysis of the K48-linked and K63-linked polyubiquitin chains. USP25 contains one ubiquitin-associa...

journal_title：Biomolecular NMR assignments

authors： Shi L,Wen Y,Zhang N

更新日期：2014-10-01 00:00:00

abstract：:RegB is involved in the control of the phage T4 life cycle. It inactivates the phage early mRNAs when their translation is no more required. We determined its structure and identified residues involved in substrate binding. For this, all backbone and 90% of side-chain resonance frequencies were assigned. ...

journal_title：Biomolecular NMR assignments

authors： Odaert B,Saïda F,Bontems F

更新日期：2007-07-01 00:00:00

abstract：:Human heterogeneous nuclear ribonucleoprotein H (hnRNP H) regulates alternative splicing of HIV-1 Tat pre-mRNA. The structure of the first N-terminal domain (residues 1-104) of hnRNP H was solved and its binding to an exonic splicing silencer (pESS2) studied. For this, all backbone and 85% of side-chain resonance freq...

journal_title：Biomolecular NMR assignments

authors： Cabal S,van Heijenoort C,Guittet E

更新日期：2007-12-01 00:00:00

abstract：:The PilF protein from the thermophilic bacterium Thermus thermophilus is a traffic ATPase powering the assembly of the DNA translocation machinery as well as of type 4 pili. Thereby PilF mediates the natural transformability of T. thermophilus. PilF contains a C-terminal ATPase domain and three N-terminal domains with...

journal_title：Biomolecular NMR assignments

authors： Neißner K,Keller H,Duchardt-Ferner E,Hacker C,Kruse K,Averhoff B,Wöhnert J

更新日期：2019-10-01 00:00:00

abstract：:NOXO1 (Nox Organizer 1) is a homolog of the NAPDH oxidase protein p47(phox). NADPH oxidases transfer electrons from NADPH to molecular oxygen, generating the superoxide anion. NOXO1 contains an N-terminal PX (phox homology) domain and is one of several PX domain-containing proteins found in the cytosolic subunits of t...

journal_title：Biomolecular NMR assignments

authors： Davis NY,McPhail LC,Horita DA

更新日期：2011-10-01 00:00:00

abstract：:Phosphoenolpyruvate binding to the C-terminal domain (EIC) of enzyme I of the bacterial phosphotransferase system (PTS) initiates a phosphorylation cascade that results in sugar translocation across the cell membrane and controls a large number of essential pathways in bacterial metabolism. EIC undergoes an expanded t...

journal_title：Biomolecular NMR assignments

authors： Dotas RR,Venditti V

更新日期：2018-04-01 00:00:00

abstract：:Ebola viral infections have resulted in several deadly epidemics in recent years in West and Central Africa. Because only one of the seven proteins encoded by the viral genome possesses enzymatic activity, disruption of protein-protein interactions is a promising route for antiviral drug development. We carried out a ...

journal_title：Biomolecular NMR assignments

authors： Lee W,Tonelli M,Wu C,Aceti DJ,Amarasinghe GK,Markley JL

更新日期：2019-10-01 00:00:00

abstract：:We report the (1)H, (13)C, and (15)N chemical shift assignments of both oxidized and reduced forms of an abundant periplasmic c-type cytochrome, designated ApcA, isolated from the acidophilic gram-negative facultatively anaerobic metal-reducing alphaproteobacterium Acidiphilium cryptum. These resonance assignments pro...

journal_title：Biomolecular NMR assignments

authors： Cort JR,Swenson MW,Magnuson TS

更新日期：2011-04-01 00:00:00

abstract：:PTPN5 is a protein tyrosine phosphatase that plays an integral role in regulating excitatory postsynaptic activity. The sequence-specific backbone assignments of the murine PTPN5 catalytic domain have been determined based on triple-resonance experiments using uniformly [(2)H,(13)C,(15)N]-labeled protein. ...

journal_title：Biomolecular NMR assignments

authors： Francis DM,Page R,Peti W

更新日期：2014-04-01 00:00:00

abstract：:Norovirus protease cleaves the virus-encoded polyprotein into six mature nonstructural proteins, presenting itself as an essential enzyme for the viral replication as well as an attractive target for the antiviral drug development. A deeper understanding of the structural mechanism of the protease-substrates/inhibitor...

journal_title：Biomolecular NMR assignments

authors： Takahashi D,Kim Y,Chang KO,Anbanandam A,Prakash O

更新日期：2012-04-01 00:00:00