Abstract:
OBJECTIVE:The incidence of inflammatory bowel disease (IBD) in Europe has increased significantly. At least a fourth of patients are children. Mannan-binding lectin (MBL) is believed to be an important component of innate immunity, acting as an opsonin and activator of the lectin pathway (LP) of complement. The data relating any of the LP factors to IBD are sparse and contradictory and were obtained mainly from adult patients. The aim of this study was to investigate the possible role of MBL in Crohn's disease (CD) and ulcerative colitis (UC) in children. METHODS:MBL2 gene single nucleotide polymorphisms (PCR-RFLP) and MBL concentrations (ELISA) were determined. RESULTS:The frequency of MBL2 gene variants responsible for MBL deficiency (LXPA/O and O/O) is significantly higher in CD patients compared with controls or children with UC. A relatively high frequency of the codon 52 mutation (D allele) was noted in these patients. Practically no difference was found between UC and control (C) groups. Similarly, the average MBL levels as well as the number of MBL-deficient (MBL concentrations < 150 ng/ml) individuals differed between CD patients and controls or children suffering from UC. Again, there was no difference between UC and C groups. CONCLUSIONS:These data suggest that MBL deficiency may be associated with CD but not with UC in pediatric patients. The possible role of MBL in IBD requires confirmation in larger series and further investigation of the mechanisms involved.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Bak-Romaniszyn L,Szala A,Sokolowska A,Mierzwa G,Czerwionka-Szaflarska M,Swierzko AS,Zeman K,Cedzynski Mdoi
10.3109/00365521.2011.594087subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1275-8issue
10eissn
0036-5521issn
1502-7708journal_volume
46pub_type
杂志文章abstract:OBJECTIVE:As a minimally invasive modality, radiofrequency ablation (RFA) has been increasingly applied not only for the treatment of hepatocellular carcinoma, but also for that of colorectal liver metastasis (CLM). However, RFA for CLM has been shown to be associated with a high local recurrence rate, and no optimal t...
journal_title:Scandinavian journal of gastroenterology
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pub_type: 杂志文章,评审
doi:10.3109/00365521.2014.894119
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abstract::A short, benign-looking stricture of the rectum presented itself clinically as subileus in a middle-aged woman after 5 years on hormone replacement therapy (HRT) and 8 years after curative surgery for cancer of the ovaries. Radiological work-up and multiple, repeated biopsies supported the endoscopically appearing ben...
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doi:10.1080/00365520510011614
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abstract::To examine the relationship between hepatitis B core antigen-specific interferon gamma production and the liver injury, we measured the sequential change in this production by peripheral blood mononuclear cells of seven patients with chronic hepatitis B. Four patients who experienced acute exacerbation showed increase...
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doi:10.3109/00365529209011173
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abstract::The aim of the present study was to compare computer-based and visual/manual scoring of pressure recordings from the gastric antrum and duodenum. The computer system was based on three separate principles of recognition: moving average, tracking base line, and threshold filters. Computer scoring resulted in the detect...
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doi:10.3109/00365529209011188
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abstract:BACKGROUND:Bacterial infections and bacteremia in acute liver failure may at least partly be attributed to translocation of enteric bacteria. Attempts to prevent or treat such infections by the use of antibiotics may instead result in overgrowth of surviving microbes. METHODS:In the present study, normal saline (1.5 m...
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doi:10.3109/00365529409094897
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更新日期:2018-06-01 00:00:00
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doi:10.1080/00365521.2018.1547921
更新日期:2018-12-01 00:00:00
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doi:10.3109/00365529609004870
更新日期:1996-03-01 00:00:00
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doi:10.3109/00365529509093288
更新日期:1995-04-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2020.1820568
更新日期:2020-11-01 00:00:00
abstract::In the period 1970 to 1987, 171 patients with small-intestinal mucosal atrophy have been hospitalized in our department. Of these, 132 patients fulfilled the diagnostic criteria of coeliac disease on the basis of histologic findings and clinical improvement on a gluten-free diet. Aspartate aminotransferase (ASAT), ala...
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doi:10.3109/00365529008997589
更新日期:1990-07-01 00:00:00
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doi:10.3109/00365521.2014.926982
更新日期:2014-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365521.2011.639083
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-05-01 00:00:00
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doi:10.1080/00365521.2017.1342140
更新日期:2017-10-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2010-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章
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更新日期:1998-05-01 00:00:00
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更新日期:2018-01-01 00:00:00