当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease.

The effect of gluten-free diet on Th1-Th2-Th3-associated intestinal immune responses in celiac disease.

Abstract：

OBJECTIVE:To study T-helper (Th)1-Th2-Th3 gene activation profile in the small intestine and peripheral blood of children with celiac disease (CD) with special interest in the response to the gluten-free diet (GFD) treatment in order to elucidate an immune dysregulation not triggered by gluten. MATERIAL AND METHODS:Small intestinal biopsies and venous blood were taken from seven children with CD (mean age: 8 years, four girls) at presentation and after 1 year of strict GFD. The Th1-Th2-Th3 gene expression profile was examined by real-time PCR arrays. The findings were compared with the corresponding expressions in peripheral blood and small intestinal biopsies from six reference children without CD (mean age: 6 years, four girls). RESULTS:The Th1 gene expression profile including interferon (IFN)-γ, signal transducer and activator of transcription (STAT) 1 and interferon regulatory factor (IRF) 1 together with reduced interleukin (IL)-2 expression was pronounced in small intestinal biopsies from children with untreated CD. A downregulation of IFN-γ transcripts was seen after 1 year of GFD, but there was still increased expression of STAT1 and IRF1 in association with low IL-2 expression in spite of eliminated exposure to wheat gluten. By contrast, the decreased intestinal expression of Th2 gene markers observed at presentation was normalized with GFD. The alterations in the mucosal gene expression profile were not reflected in peripheral blood. CONCLUSION:The GFD did not correct the increased activation of the IFN-γ signaling pathway related markers and reduced IL-2 expression, suggesting that they represent an immune dysregulation not dependent on gluten exposure.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Lahdenperä A,Ludvigsson J,Fälth-Magnusson K,Högberg L,Vaarala O

doi

10.3109/00365521.2011.551888

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

538-49

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

46

pub_type

杂志文章

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