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Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-α-stimulated human gingival epithelial cells.

Abstract：

BACKGROUND AND OBJECTIVE:As epithelial cells function as a mechanical barrier, the permeability of the gingival epithelial cell layer indicates a defensive capability against invasion by periodontal pathogens. We have reported the expression of claudin-1 and E-cadherin, key regulators of permeability, in the gingival junctional epithelium. Irsogladine maleate (IM) is a medication for gastric ulcers and also regulates Aggregatibacter actinomycetemcomitans-stimuated chemokine secretion and E-cadherin expression in gingival epithelium. In this study, we have further investigated the effects of IM on the barrier functions of gingival epithelial cells under inflammatory conditions. MATERIAL AND METHODS:We examined the permeability, and the expression of claudin-1 and E-cadherin, in human gingival epithelial cells (HGECs) stimulated with tumor necrosis factor (TNF)-α, with or without IM. RESULTS:TNF-α increased the permeability of HGECs, and IM abolished the increase. TNF-α reduced the expression of E-cadherin in HGECs, and IM reversed the reduction. In addition, immunofluorescence staining showed that TNF-α disrupted claudin-1 expression in HGECs, and IM reversed this effect. CONCLUSION:The results suggest that IM reverses the TNF-α-induced disruption of the gingival epithelial barrier by regulating E-cadherin and claudin-1.

journal_name

J Periodontal Res

journal_title

Journal of periodontal research

authors

Fujita T,Yumoto H,Shiba H,Ouhara K,Miyagawa T,Nagahara T,Matsuda S,Kawaguchi H,Matsuo T,Murakami S,Kurihara H

doi

10.1111/j.1600-0765.2011.01404.x

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

55-61

issue

1

eissn

0022-3484

issn

1600-0765

journal_volume

47

pub_type

杂志文章

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