Tumor necrosis factor-alpha stimulates gingival epithelial cells to release high mobility-group box 1.

abstract：BACKGROUND AND OBJECTIVES:The expression of A Disintegrin and Metalloproteinase 8 (ADAM8) is associated with several inflammatory diseases. Elevated ADAM8 levels have been shown in gingival crevicular fluid of patients with chronic periodontitis. The objective of this study was to investigate ADAM8 expression in chroni...

journal_title：Journal of periodontal research

authors： Aung WPP,Chotjumlong P,Pata S,Montreekachon P,Supanchart C,Khongkhunthian S,Sastraruji T,Krisanaprakornkit S

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Vitamin D-1,25(OH)2 D3 or 1,25D3-maintains healthy osseous tissue, stimulates the production of the antimicrobial peptide cathelicidin and has anti-inflammatory effects, but it can cause hypercalcemia. Evidence links diminished serum levels of 1,25D3 with increased gingival inflammation. Period...

journal_title：Journal of periodontal research

authors： Nakashyan V,Tipton DA,Karydis A,Livada R,Stein SH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Proinflammatory cytokines such as interleukin-1beta are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-kappaB (NF-kappaB). Although numerous effects of interleukin-1beta on mesenchymal cells are known, e.g. up-regu...

journal_title：Journal of periodontal research

authors： Steinberg T,Dannewitz B,Tomakidi P,Hoheisel JD,Müssig E,Kohl A,Nees M

更新日期：2006-10-01 00:00:00

abstract：:Multinucleated cells (MNCs) that appeared after hydroxyapatite (HAP) implantation into experimentally-produced bone defects in rat periodontal tissues were investigated both ultrastructurally and ultracytochemically. At day 5 after implantation, MNCs first appeared along the HAP surface. They had no features of typica...

journal_title：Journal of periodontal research

authors： Kawaguchi H,Ogawa T,Shirakawa M,Okamoto H,Akisaka T

更新日期：1992-01-01 00:00:00

abstract：:Numerous studies report that water fluoridation reduces caries in children, but little current evidence exists about fluoridation's effects on the periodontal health of adults. To address this issue, we estimated fluoridation effects on periodontal disease among 1066 Washington state employees and their spouses, aged ...

journal_title：Journal of periodontal research

authors： Grembowski D,Fiset L,Spadafora A,Milgrom P

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cigarette smoking has detrimental effects on periodontal tissue, and is known to be a risk factor for periodontal disease, including the loss of alveolar bone and ligament tissue. However, the direct effects of cigarette smoking on periodontal tissue remain unclear. Recently, we demonstrated th...

journal_title：Journal of periodontal research

authors： Monnouchi S,Maeda H,Yuda A,Serita S,Wada N,Tomokiyo A,Akamine A

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Enamel matrix derivative (EMD), extracted from porcine tooth buds, has been shown to promote periodontal healing in patients with severe periodontitis. This involves modulation of the inflammatory response followed by the onset of periodontal regeneration. Based on these observations, we examin...

journal_title：Journal of periodontal research

authors： Myhre AE,Lyngstadaas SP,Dahle MK,Stuestøl JF,Foster SJ,Thiemermann C,Lilleaasen P,Wang JE,Aasen AO

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The field of salivary diagnostics lacks an accepted and validated biomarker of alveolar bone remodeling. To address this, we examined levels of salivary biomolecules specifically associated with biological aspects of bone remodeling in subjects with chronic periodontitis in a case-control study...

journal_title：Journal of periodontal research

authors： Al-Sabbagh M,Alladah A,Lin Y,Kryscio RJ,Thomas MV,Ebersole JL,Miller CS

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Periodontitis may alter the systemic condition in patients with diabetes and hence interfere with glycemic control. The objective of this study was to determine the quantifiable changes in glycated hemoglobin (HbA1C) after periodontal non-surgical therapy plus azithromycin in a mixed population...

journal_title：Journal of periodontal research

authors： Botero JE,Yepes FL,Ochoa SP,Hincapie JP,Roldan N,Ospina CA,Castrillon CA,Becerra MA

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Tooth loss (TL), one of the most visible results of the evolution of periodontitis, causes physiological and psychological impacts on a patient's life. This prospective study aimed to evaluate the incidence, underlying reasons and influence of risk predictors for the occurrence of TL in a progr...

journal_title：Journal of periodontal research

authors： Costa FO,Lages EJ,Cota LO,Lorentz TC,Soares RV,Cortelli JR

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Multiple studies support the role of periodontal disease in contributing to the chronic systemic inflammatory burden in a variety of diseases, including ankylosing spondylitis (AS), in the progression which the inflammatory process plays an important role. We assume that patients with AS are mo...

journal_title：Journal of periodontal research

authors： Sezer U,Erciyas K,Pehlivan Y,Ustün K,Tarakçioğlu M,Senyurt SZ,Onat AM

更新日期：2012-06-01 00:00:00

abstract：:We have studied the polymorphonuclear leukocyte (PMN) phagocytosis of Porphyromonas gingivalis (Bacteroides gingivalis) and Prevotella intermedia (Bacteroides intermedius) in three-dimensional fibrin meshworks formed by either clotting human plasma or by clotting purified fibrinogen with human serum incorporated. PMN ...

journal_title：Journal of periodontal research

authors： Hurst TJ,Wilton JM

更新日期：1992-03-01 00:00:00

abstract：:Quantitative assessment of osseous changes attributable to periodontal disease is made possible by digital subtraction radiography. Tissues through which x rays travel to produce dental radiographs essential to this process alter the energy spectrum of the beam such that calibration errors result when densitometry is ...

journal_title：Journal of periodontal research

authors： Webber RL,Tzukert A,Ruttimann U

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The association between periodontal disease and nutrient intake was examined using linked data from the 2005 National Health and Nutrition Survey, the Comprehensive Survey of Living Conditions and the Survey of Dental Diseases from the same year 'using linked data from the National Health and N...

journal_title：Journal of periodontal research

authors： Hamasaki T,Kitamura M,Kawashita Y,Ando Y,Saito T

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The -2518MCP-1(A/G) polymorphism has been implicated as a risk or susceptibility factor...

journal_title：Journal of periodontal research

authors： Zhu XL,Meng HX,Zhang L,Xu L,Chen ZB,Shi D,Feng XH,Zhang X

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Recent epidemiological studies have shown that individuals with periodontitis have a significantly increased risk of developing coronary heart disease. In addition to conventional risk factors, chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased ...

journal_title：Journal of periodontal research

authors： Yamazaki K,Honda T,Oda T,Ueki-Maruyama K,Nakajima T,Yoshie H,Seymour GJ

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipocytes, macrophages and microvascular endothelial cells, and it plays a central role in inflammation, atherosclerosis and metabolic responses. This pilot study investigated the effect of nonsurgical periodontal therapy on the ser...

journal_title：Journal of periodontal research

authors： Li X,Tse HF,Yiu KH,Zhang C,Jin LJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Studies have shown that bacterial plaque and the associated gingival inflammation increase the severity of gingival overgrowth induced by cyclosporine-A (CsA). This in vitro study aimed to evaluate the effect of CsA on the activities of MMPs from the co-culture of human gingival fibroblasts and...

journal_title：Journal of periodontal research

authors： Kuo PJ,Tu HP,Chin YT,Lu SH,Chiang CY,Chen RY,Fu E

更新日期：2012-08-01 00:00:00

abstract：:To investigate the effect of lipopolysaccharide (LPS) on phagocytic activity of collagen fibrils by periodontal fibroblasts, we studied rat molar gingival connective tissue and periodontal ligament under light and electron microscopy after topical application of LPS (5 mg/ml in physiological salt solution (PS)) on the...

journal_title：Journal of periodontal research

authors： Ijuhin N,Miyauchi M,Ito H,Takata T,Ogawa I,Nikai H

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Gingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies a...

journal_title：Journal of periodontal research

authors： Milinkovic I,Aleksic Z,Jankovic S,Popovic O,Bajic M,Cakic S,Lekovic V

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Periodontitis is characterized by altered bone turnover, but local measurements are difficult. OBJECTIVES:The objective of this study was to develop a method to measure multiple markers of bone turnover from single samples collected at various bone surfaces of the periodontium, and to test the ratios of the...

journal_title：Journal of periodontal research

authors： Wilson AN,Schmid MJ,Marx DB,Reinhardt RA

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Metabolic syndrome (MetS) is a combination of risk factors (e.g. impaired glucose tolerance, hypertension, and dyslipidaemia) that significantly contribute to the development of cardiovascular diseases. The aim of the study was to compare the effects of nonsurgical periodontal treatment (NSPT) ...

journal_title：Journal of periodontal research

authors： Torumtay G,Kırzıoğlu FY,Öztürk Tonguç M,Kale B,Calapoğlu M,Orhan H

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The responsiveness of the sympathetic nervous system (SNS) and the hypothalamic--pituitary--adrenal (HPA) axis plays a major role in immune regulation and for the outcome of infections and inflammatory disorders. This study was designed to investigate whether chemical SNS denervation with the noradrenaline-se...

journal_title：Journal of periodontal research

authors： Breivik T,Gundersen Y,Opstad PK,Fonnum F

更新日期：2005-08-01 00:00:00

abstract：:Ketoprofen creams were evaluated for the treatment of periodontal disease in a placebo-controlled, double-blind study in the rhesus monkeys, Macaca mulatta. Two formulations containing ketoprofen (1%), with or without vitamin E, were evaluated against appropriate controls (8 monkeys per group). Two weeks prior to trea...

journal_title：Journal of periodontal research

authors： Li KL,Vogel R,Jeffcoat MK,Alfano MC,Smith MA,Collins JG,Offenbacher S

更新日期：1996-11-01 00:00:00

abstract：:The onset and progression of periodontal disease is associated with significant changes in the epithelial component of the attachment complex. From the early to the advanced stages of periodontal disease increased epithelial cell proliferation, migration and invasion into the surrounding connective tissue takes place....

journal_title：Journal of periodontal research

authors： Sanale AR,Firth JD,Uitto VJ,Putnins EE

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate the presence of factor XIIIa+ dendritic cells and S-100 protein+ Langerhans' cells in the gingival epithelium and connective tissue of periodontal pockets, before and after non-surgical periodontal therapy. BACKGROUND:The microbial flora in periodontal pockets provok...

journal_title：Journal of periodontal research

authors： Dereka XE,Tosios KI,Chrysomali E,Angelopoulou E

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Biofilm formation occurs through the events of cooperative growth and competitive survival among multiple species. Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans are important periodontal pathogens. The aim of this study was to demonstrate competitive or cooperative interact...

journal_title：Journal of periodontal research

authors： Takasaki K,Fujise O,Miura M,Hamachi T,Maeda K

更新日期：2013-06-01 00:00:00

abstract：:Recently, nitric oxide (NO) has been shown to be vital in inflammatory processes. Nitric oxide synthase (NOS) exists in three different isoforms, two constitutively produced with physiological roles, and an inducible form, iNOS, which is involved in inflammation. This study examined the localisation of iNOS in biopsie...

journal_title：Journal of periodontal research

authors： Lappin DF,Kjeldsen M,Sander L,Kinane DF

更新日期：2000-12-01 00:00:00

abstract：:This study investigates a potential role for TGF beta 1 in the pathogenesis of cyclosporin A-induced gingival overgrowth (CsA-OG). TGF beta 1 was localized immunohistochemically in the connective tissue of both normal gingiva and CsA-OG. Intense staining for TGF beta 1 was detected at the tips of the dermal papillae o...

journal_title：Journal of periodontal research

authors： James JA,Irwin CR,Linden GJ

更新日期：1998-01-01 00:00:00

abstract：:The 160, 190 and 270 kDa outer sheath proteases of Treponema denticola ATCC 35404 were found to be multiple forms of the major 91 kDa phenylalanine protease (PAP) by immunoblotting using anti-91 kDa specific antibodies. Multiple forms of the phenylalanine protease were also found in 2 other T. denticola strains studie...

journal_title：Journal of periodontal research

authors： Rosen G,Naor R,Sela MN

更新日期：1999-07-01 00:00:00