Abstract：
:Diffusion tensor imaging (DTI) was used to investigate the involvement of brain white matter in Williams syndrome (WS), a genetic neurodevelopmental disorder. Whole-brain DTIs were obtained from 16 young adults with WS and 16 normal controls. A voxel-based analysis was performed to compare fractional anisotropy (FA) values between the two groups. A tract-based analysis was also performed to compare FA values between the two groups along two major white matter tracts that pass through the external capsule: the uncinate and inferior fronto-occipital fasciculi. Several regions of both increased and decreased FA were found within major white matter tracts that connect functional regions that have previously been implicated in the cognitive and neurological symptoms of the syndrome. The tract-based analysis provided additional insight into the involvement of specific white matter tracts implicated in the voxel-based analysis within the external capsule. The results from this study support previously reported changes in white matter diffusion properties in WS and demonstrate the potential usefulness for tract-based analysis in future studies of the disorder.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Arlinghaus LR,Thornton-Wells TA,Dykens EM,Anderson AWdoi
10.1016/j.mri.2011.07.012subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1165-74issue
9eissn
0730-725Xissn
1873-5894pii
S0730-725X(11)00242-6journal_volume
29pub_type
杂志文章abstract：:Blood circulation is an important determinant of the biodistribution of superparamagnetic iron oxide nanoparticles. Here we present a magnetic resonance imaging (MRI) technique based on the use of ultrafast echo times (UTE) for the noninvasive determination of blood half-lives at high particle concentrations, when con...
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更新日期：2013-06-01 00:00:00
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