Abstract:
:Blood circulation is an important determinant of the biodistribution of superparamagnetic iron oxide nanoparticles. Here we present a magnetic resonance imaging (MRI) technique based on the use of ultrafast echo times (UTE) for the noninvasive determination of blood half-lives at high particle concentrations, when conventional pulse sequences fail to produce a useful MR signal. Four differently coated iron oxide nanoparticles were administered intravenously at a dose of 500 μmol Fe/kg bodyweight and UTE images of C57BL/6 mice were acquired on a 1-T ICON scanner (Bruker). T2* relaxometry was done by acquiring UTE images with echo times of 0.1, 0.8 and 1.6 ms. Blood circulation time was then determined by fitting an exponential curve to the time course of the measured relaxation rates. Circulation time was shortest for particles coated with malic acid (t1/2=23 min) and longest for particles coated with tartaric acid (t1/2=63 min). UTE-based T2* relaxometry allows noninvasive determination of blood circulation time and is especially useful when high particle concentrations are present.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Scharlach C,Warmuth C,Schellenberger Edoi
10.1016/j.mri.2015.06.017subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1173-1177issue
9eissn
0730-725Xissn
1873-5894pii
S0730-725X(15)00162-9journal_volume
33pub_type
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journal_title:Magnetic resonance imaging
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更新日期:2012-05-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(97)00038-6
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pub_type: 杂志文章,评审
doi:10.1016/0730-725x(95)02036-s
更新日期:1995-01-01 00:00:00
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doi:10.1016/j.mri.2013.12.004
更新日期:2014-04-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(98)00123-4
更新日期:1998-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0730-725x(01)00287-9
更新日期:2001-04-01 00:00:00
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更新日期:2008-07-01 00:00:00
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更新日期:2014-04-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(90)90089-k
更新日期:1990-01-01 00:00:00
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更新日期:2018-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00